Workshop: Genomic and Computational Approaches for Biomarker and Drug Discovery
Date:
June 19, 2015 - 2:00 PM to June 19, 2015 - 5:00 PMDetails:
Note: space is limited to 50 participants; please RSVP by May 1, 2015 to M. Reilly at reillymt@mail.nih.gov.
Purpose: to bring together (Library of Integrated Network-based Cellular Signatures) LINCS1 scientists and scientists from the alcohol research community to explore how LINCS resources can facilitate identification of druggable targets and novel and/or repurposed compounds for the treatment of alcohol dependence
ABSTRACT:
Workshop: Genomic and Computational Approaches for Biomarker and Drug Discovery
The basic molecular components of biological systems (e.g., DNA, RNA, proteins) form self-organizing cellular networks that interact to provide the capacity for an astounding array of biological complexity. The non-linear dynamic interactions of these networks result in emergent properties that appear at higher levels of biological organization (i.e., organs such as the brain). For example, the interactions of complex neural networks in the brain emerge as properties such as exquisite cognitive abilities and the generation of the diversity of behaviors demonstrated by our species. Understanding how the complexity of these biological pathways and networks are maintained in health, and how they become perturbed by genetic and environmental stressors that cause disease, is challenging but essential to developing new and better therapies to return perturbed networks to their normal state.
The NIH’s Library of Integrated Network-based Cellular Signatures (LINCS) program is developing a “library” of molecular signatures, based on gene expression and other cellular changes that describe the response that different types of cells elicit when exposed to various perturbing agents, including genetic perturbations and small bioactive molecules (including a large panel of FDA-approved compounds). High-throughput screening approaches are used to interrogate the cells and mathematical approaches are used to describe the molecular changes and patterns of response i.e., “cellular signature”.
LINCS data and computational tools are publically available as a community resource (e.g., www.lincscloud.org). LINCS resources have already facilitated the identification of neurobiological targets and novel and repurposed compounds for the treatment of various diseases including Alzheimer’s, Parkinson’s, and nicotine dependence. Therefore, the purpose of this meeting will be to bring together LINCS scientist and scientist from the alcohol research community to explore how LINCS resources can facilitate identification of druggable targets and novel and/or repurposed compounds for the treatment of alcohol dependence.
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Location:
San Antonio, TX
Grand Hyatt, San Antonio
Room: Travis C/D
Event Category: Symposium