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In this Section
- Office of the Scientific Director
- Office of the Clinical Director
- NIAAA Laboratories
- Laboratory of Behavioral & Genomic Neuroscience
- Laboratory of Cardiovascular Physiology and Tissue Injury
- Laboratory for Integrative Neuroscience
- LIN - Office of the Chief
- LIN - Section on Neuronal Structure
- LIN - Section of Synaptic Pharmacology (SP)
- Laboratory of Liver Diseases
- Laboratory of Metabolic Control
- Laboratory of Molecular Signaling
- Laboratory of Molecular Physiology
- Laboratory of Membrane Biochemistry and Biophysics
- Laboratory of Neurogenetics
- Laboratory for Neuroimaging
- Laboratory of Physiologic Studies
- Chemical Biology Research Branch (joint lab with NIDA)
- Clinical NeuroImaging Core
- Section on Clinical Genomics and Experimental Therapeutics (CGET)
- Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)
- Section on Human Psychopharmacology (HP)
- Office of Laboratory Animal Science (OLAS)
- Research and Training
- Clinical Trials at NIAAA/NIH
Clinical NeuroImaging Research Core
What we do
The Clinical NeuroImaging Research Core (CNIRC) serves two functions: Conducting independent addiction neuroimaging studies and providing imaging expertise, through imaging collaborations and support to clinical investigators.
Research interests include:
- Identify and investigate the neural substrates and neurocircuitries associated with stages of alcohol use and misuse.
- Examine the dynamic relationship between brain structure and function and alcohol use disorders.
- Utilize imaging phenotypes to establish efficacy of experimental treatments and therapies.
- Utilize imaging biomarkers to predict treatment outcome and relapse.
Clinical collaborations and support include:
- Enhance imaging capabilities
- Prototype paradigms and methodologies
- Assist PI’s in protocol development with imaging components, including, for example advice on practicality, power analysis, etc.
- Conduct imaging components of the studies including:
- Implement imaging paradigms
- Supervise/conduct scanning sessions
- Perform image processing
- Perform imaging analyses
- Present imaging results
- Develop and provide imaging informatics
- Standardize and track imaging data
- Provide imaging study database
- Provide recommendations to the OSD and OCD in prioritization and advance planning of the studies involving neuroimaging.
- Provide Intramural and NIH Clinical Elective Program trainings in imaging
Reza Momenan, PhD, Director
Dr. Momenan provides neuroimaging research expertise and support in the areas of experimental design, imaging, and analysis to NIAAA Intramural program. His main focus of research has been design and developing experiments utilizing various MR modalities for study of motivation, impulsivity, and emotions as related to addiction. His current focus is in utilization of neuroimaging phenotypes to investigate sub-types of alcohol use disorders. Dr. Momenan is also interested in the use of innovative approaches such as those of machine learning algorithms to predict alcohol use disorders, treatment efficacy, and relapse.
Dan Rio, PhD
Dr. Rio is a physicist/mathematician who setup the original clinical imaging facilities in NIAAA. His current interest is developing new models for analysis of functional MRI in addition to providing support in the areas of computational mathematics, mathematical modeling, image processing and experimental design.
Computer Program Specialist
Michael Kerich joined NIAAA in 1986 as a Computer Specialist/Scientist after received his BS in Chemistry/Minor in Biochemistry with honors in 1982 and his BS in Computer Science in 1986. He has been involved in the collection and processing of structural and functional images for the NIAAA. He also helps retrieve and integrate psychological, genetic, and demographic data with the imaging data for analysis. He maintains the linux systems used for analysis and backups all the imaging data for the CNIRC. He also provides limited desktop support for users in the Core. He also helps develop electronic data entry forms and kiosks using Filemaker for the lab.
Carlos R. Cortes, M.D., Ph.D.
Dr. Cortes received his Medicine and Surgery Doctoral Degree from the Universidad Industrial de Santander (Bucaramanga, Colombia) in 1995 and his Ph.D. degree from University of Maryland Baltimore County in 2013. His previous experience includes: primary care physician in Colombia, visiting research fellow in the International Center for Mental Health at Mount Sinai School of Medicine, NY, supervisor/therapist in a community mental health center in Allentown, PA and research associate at the Maryland Psychiatric Research Center, University of Maryland, Baltimore. He joined the NIAAA in October 2013 (Postdoctoral Intramural Research Training Award). Dr. Cortes is interested on combining multimodal neuroimaging and computational modeling to elucidate possible pathophysiological mechanisms underlying clinical features in addiction.
Erica Grodin, BA, GPP
Brown University and National Institutes of Health
Erica Grodin joined NIAAA in 2010. She is a graduate student studying neuroscience in the Brown University/NIH Graduate Partnerships Program. She graduated from American University in 2010, where her work focused on the conditioned taste aversion phenomenon. Her Ph.D. dissertation work focuses on investigating the neural correlates of compulsive drinking, particularly why people continue drinking despite adverse consequences. Her previous research focused on the structural correlates of alcoholism and the effect of co-morbid substance abuse.
Karan Mathur, BS, Postbac-IRTA
Phone: (301) 827-0321
Karan Mathur joined the NIAAA in July 2013 after graduating from Virginia Tech with a Bachelor of Science in Biochemistry with a minor in Interdisciplinary Engineering and Science. His research experience as an undergraduate involved studying the role of nanomaterials in medical applications and drug delivery. In addition, he has conducted research in the field of genetic and metabolic engineering by studying the potential of B. Subtilis to synthesize biofuels. Karan’s responsibilities include phone screening, administering assessments and clinical interviews, and conducting fMRI studies that explore the neuro-circuitry of addiction.
Sasha Brietzke, BA, Postbac IRTA
Phone: (301) 496-7513
Sasha Brietzke joined NIAAA in June 2014 after graduating from Johns Hopkins University. Sasha’s responsibilities include phone screening, running screening visits and imaging sessions, administering clinical interviews and cognitive tasks, entering data, and performing analysis. She is interested in the neurobiology of addiction and biomedical imaging statistics applied to functional and structural neuroimaging.
Kelsey Sundby, BA, Postbac IRTA
Phone: (301) 435-0686
Kelsey Sundby joined NIAAA in June 2014 after graduating from the University of Virginia. Her primary interests are in clinical psychology and social neuroscience. Her work in the lab includes phone screening, coordinating and running both screening and fMRI visits, administering assessments and clinical interviews, and data entry and analysis.
Nicole MacIlvane, BS, Postbac IRTA
Nicole MacIlvane joined the Clinical NeuroImaging Research Core in February 2016 after completing her studies in Neuroscience and Psychology at The Ohio State University. As an undergraduate her research focused on the neurobiology of learning and memory in a rat model of Fetal Alcohol Spectrum Disorder. She now explores the neural substrates of alcoholism and alcohol abuse through imaging and neuropsychological tasks, with the aim of developing clinical interventions.
Sanket Gupte, M.S. Programmer Analyst/Systems Administrator
Sanket Gupte joined NIAAA in April 2012. He completed his M.S. In Computer Science from University of Maryland Baltimore County and is currently pursuing his Ph.D. in the same field. His main duties include designing software applications for processing and analysis of neuroimaging and genetics data. He also develops and maintains a web based software repository for storing MRI Imaging data, that allows easy interfacing, processing, clustering and analysis. His other duties also include managing and administering Linux Systems. He shares his time between CNIRC and NRB-Bran
14-AA-0094 Neural Substrate of Approach Avoidance in Alcoholism
14-AA-0066 Behavioral and Functional MRI Task Development, Implementation, and Testing
14-AA-0080 Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
15-AA-0203 Cross-Sectional and Longitudinal Study of Structural Imaging
Vladimir V. Senatorov, Claire L. Mann, Melanie L. Schwandt, Markus Heilig, Daniel W. Hommer, Reza Momenan, Reduced anterior insula and enlarged amygdala, nucleus accumbens, and thalamus in alcohol dependent patients: a magnetic resonance imaging study of alcoholism, Brain (accepted).
Durkee C, Sarlls J, Hommer D, Momenan R, White matter microstructure alterations: a study of alcoholics with and without post-traumatic stress disorder, PLoS One (2013) Volume 8, Issue 11, e80952, 1-10. PubMed
Leah M. Mayo, Diana Fraser, Emma Childs, Reza Momenan, Daniel Hommer, Harriet de Wit, Markus Heilig, Conditioned preference to a methamphetamine-associated contextual cue in humans, Journal of Neuropsychopharmocology (2013) 38, 921–29. PubMed
Grodin E., Lin H., Hommer, D.W., Durkee, C.A., Momenan R., Deficits in cortical, diencephalic and midbrain gray matter in alcoholism measured by VBM: Effects of co-morbid substance abuse, NeuroImage: Clinical (2013) 2: 469-76. PubMed
Momenan, R., Steckler L.E., Saad Z., van Rafelghem S., Kerich, M., and Hommer, D.W., Effects of alcohol dependence on cortical thickness (2012), Psychaiatry Research: Neuroimaging, Volume 204, Issues 2–3, 30 November (2012), Pages 101–111. PubMed
Bjork JM, Chen G, Smith AR, Hommer DW: Incentive-elicited mesolimbic activation in adolescents with externalizing disorders. Journal of Child Psychology & Psychiatry. 2010 Jul 11;51(7):827-37. PubMed
Gilman JM, Davis MB, Hommer DW: Greater activation in left hemisphere language–related regions during simple judgment tasks among substance-dependent patients in treatment for alcoholism. Alcoholism: Clinical and Experimental Research. 2010 Feb;34(2):331–41. PubMed
Bjork JM, Momenan R, and Hommer DW: Delay discounting correlates with proportional lateral frontal cortex volumes. Biological Psychiatry. 2009 Apr 15;65(8):710-3. PubMed
Bjork JM, Smith AR, Hommer DW: Striatal sensitivity to reward deliveries and omissions in substance dependent patients, NeuroImage. 2008 Oct 1;42(4):1609-21. PubMed
Gilman JM, Hommer DW. Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients. Addiction Biology. 2008 Sep;13(3-4):423-34. PubMed
Bjork JM, Knutson B, Hommer DW: Incentive-elicited striatal activation in adolescent children of alcoholics. Addiction. 2008 Aug;103(8):1308-19. PubMed
Bjork JM, Momenan R, Smith A, Hommer DW. Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients. Alcohol and Drug Dependence. 2008 May 1;95(1-2):115-28. PubMed
Gilman JM, Ramchandani VA , Davis MB , Bjork JM, Hommer DW. Why we like to drink: An fMRI Study of the Rewarding and Anxiolytic Effects of Alcohol. Journal of Neuroscience. 2008 Apr 30;28(18):4583-91. PubMed
George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt J, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M. Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science. 2008 Mar 14;319(5869):1536-9. PubMed
Gilman JM, Bjork JM, Hommer DW. Parental alcohol use and brain volumes in early- and late-onset alcoholics. Biological Psychiatry. 2007 Sep 15;62(6):607-15. PubMed
Salloum JB, Ramchandani VA, Bodurka J, Rawlings R, Momenan R, George D, Hommer DW. Blunted rostral anterior cingulate response during a simplified decoding task of negative facial expressions in alcoholic patients. Alcoholism: Clinical and Experimental Research. 2007 Sep;31(9):1490-504. PubMed
Schottenbauer MA, Hommer D, Weingartner H. Memory deficits among alcoholics: Performance on a selective reminding task. Aging, Neuropsychology, and Cognition. 2007 Sep;14(5):505-516. PubMed
Bjork JM, Smith A, Danube C, Hommer DW. Developmental differences in posterior mesofrontal cortex recruitment by risky rewards. Journal of Neuroscience. 2007 May 2;27(18):4839-49. PubMed
Schottenbauer MA, Momenan R, Kerich M, Hommer DW. Relationships among aging, IQ, and intracranial volume in alcoholics and control subjects. Neuropsychology. 2007 May;21(3):337-45. PubMed
Bjork JM, Hommer DW. Anticipating instrumentally obtained and passively-received rewards: A factorial fMRI investigation. Behavioural Brain Research. 2007 Feb 12;177(1):165-70. PubMed
Brown AK, George DT, Fujita M, Liow J, Ghose S, Sangare J, Hommer DW, Innis RB. PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcoholism: Clinical and Experimental Research. 2007 Jan;31(1):28-32. PubMed
Rio DE, Rawlings RR, Woltz LA, Salloum JB, Hommer DW. Single subject image analysis using complex general linear model - An application to functional magnetic imaging with multiple inputs. Computer Methods and Programs in Biomedicine. 2006 Apr;82(1):10-9. PubMed
Bjork JM, Hommer DW, Grant SJ, Danube C. Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. Alcohol. 2004 Oct-Nov;34(2-3):133-50. PubMed
Knutson B, Bjork JM, Fong GW, Hommer D, Mattay VS, Weinberger DR. Amphetamine modulates human incentive processing. Neuron. 2004 Jul 22;43(2):261-9. PubMed
Momenan R, Rawlings R, Fong G, Knutson B, Hommer D. Voxel-based homogeneity probability maps of gray matter in groups: assessing the reliability of functional effects. Neuroimage. 2004 Mar;21(3):965-72. PubMed
Bjork JM, Knutson B, Fong GW, Caggiano DM, Bennett SM, Hommer DW. Incentive-elicited brain activation in adolescents: similarities and differences from young adults. J Neurosci. 2004 Feb;24(8):1793-802. PubMed
Bjork JM, Grant SJ, Hommer DW. Cross-sectional volumetric analysis of brain atrophy in alcohol dependence: effects of drinking history and comorbid substance use disorder. Am J Psychiatry. 2003 Nov;160(11):2038-45. PubMed
REVIEWS AND BOOK CHAPTERS
Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Le, AD, Hipskind, PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh, J, Tauscher JT, Hunt SP, Hommer, D, Heilig M: Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol. 2009 Nov;43:491-8. PubMed
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