Curriculum Vitae

Fumihito Ono, M.D., Ph.D.
TS32, 5625 Fishers Lane, Rockville, MD, 20852
Phone: 301-443-3748
Fax: 301-480-8035
Email: onof@mail.nih.gov

 

Education

04/1991 M.D., Faculty of Medicine, University of Tokyo

06/1991-05/1992 Resident, Internal Medicine, National Medical Center Hospital, Tokyo

07/1996 Ph.D., Faculty of Medicine, University of Tokyo

 

Research Experience

01/1996- 11/1998 Postdoctoral Fellow of the Japan Society for the Promotion of Science

11/1998- 08/2000 Postdoctoral Fellow, SUNY at Stony Brook

09/2000- 10/2003 Research Assistant Professor, SUNY at Stony Brook

11/2003- 5/28/2007 Assistant Professor, the Whitney Laboratory for Marine Bioscience & Department of Neuroscience, University of Florida

5/29/2007- Chief, Section on Model Synaptic Systems, Laboratory of Molecular Physiology, NIAAA/NIH

 

License and Certification

1991 American Medical License Registration (Foreign Medical Graduates Examination)

1991 Japanese Medical License Registration

 

Professional membership and other experience

1998- Member, Society for Neuroscience

2009- Member, NIAAA Animal Care and Use Committee

2012  Panelist, NIH-JSPS Fellowship Review Committee

Ad hoc reviewer for journals: American Journal of Physiology, Alcohol, Canadian Journal of Zoology, Developmental Biology, Disease Models & Mechanisms, FASEB Journal, Journal of Neuroscience, Journal of Physiology, Molecular Endocrinology, Neuropharmacology, Neuroscience Research, Reproductive Toxicology

Ad hoc reviewer for grants: The Netherlands Organization for Health Research and Development, Natural Sciences and Engineering Research Council of Canada, National Science Foundation, Japan Society for the Promotion of Science, National Institute of Health

 

Awards and grants

Postdoctoral Fellowship (Japan Society for the Promotion of Science)   1996-1998

Muscular Dystrophy Association, Research Grant   07/2004– 06/2007       $297,000

NIH 1 R01 NS050388-01A1   07/01/2005 - 06/30/2009      $942,112

 

Publications

Ono, F. (2012) Big answers from a small fly with a cultured brain. Journal of Physiology in press.

Walogorsky, M., Wen, H., Mongeon, R., Urban, J., Ono, F., Mandel, G., Brehm, P. (2012) A zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery. Proceedings of the National Academy of Sciences 109: 17711-17716.

Won, Y., Ono, F., Ikeda, S. (2012) Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE 7: e42602.

Papke, R., Ono, F., Stokes, C., Urban, J., Boyd, T. (2012) The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study. Biochemical Pharmacology 84:352-365.

Park, J., Ikeda, H, Ikenaga, T., Ono, F. (2012) Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane. Journal of Neuroscience 32:7356-7363.

Nakayama, S., Ikenaga, T., Kawakami, K., Ono, F., Hatta, K. (2012) A Gal4 gene trap line useful for studying the morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development. Development Growth and Differentiation 54: 202-215.

Mongeon, R., Walogorsky, M., Urban, J., Mandel, G., Ono, F., Brehm, P. (2011) An acetylcholine receptor lacking both g and e subunits mediates transmission in zebrafish slow muscle synapses. Journal of General Physiology 138: 353-366.

Ikenaga, T., Urban, J., Gebhart, N., Hatta, K., Kawakami, K., Ono, F. (2011) Formation of the spinal network in zebrafish determined by domain-specific Pax genes. Journal of Comparative Neurology 519: 1562-1579.

Diep, C., Ma, D., Arora, N., Wingert, R., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., Ikenaga, T., Ono, F., Englert, C., Hukriede, N., Handin, R., Davidson, A. (2011) Identification of adult renal progenitor cells capable of nephron formation and regeneration in zebrafish, Nature 470: 95-100.

Won, Y., Ono, F., Ikeda, S. (2011) Identification and modulation of voltage-gated Ca2+ current in zebrafish Rohon-Beard neurons, Journal of Neurophysiology 105: 442-453.

Epley, K., Urban, J., Ikenaga, T., and Ono, F. (2008) A modified acetylcholine receptor d-subunit enables a null mutant to survive beyond sexual maturation.  Journal of Neuroscience 28: 13223-13231.

Ono, F. (2008) An emerging picture of synapse formation: A balance of two opposing pathways. Science Signaling 1, pe3.

Ibanez-Tallon, I., Wen, H., Miwa, J.M., Xing, J., Tekinay, AB., Ono, F., Brehm, P.,  and Heintz, N. (2004) Tethering naturally occurring Peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo. Neuron 43:305-11.

Luna, V., Wang, M., Ono, F., Gleason, M., Dallman, J., Mandel, G., and Brehm, P. (2004) Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. Journal of Neurophysiology 92:2003-2009.

Ono, F., Mandel, G., and Brehm, P. (2004) Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish. Journal of Neuroscience 24:5475-5481.

Lefebvre, J.L., Ono, F., Puglielli, C., Saidner, G., Franzini-Armstrong, C., Brehm, P., and Granato, M. (2004) Increased neuromuscular activity causes axonal defects and muscle degeneration. Development 31:2605-2618.

Li, W., Ono, F., and Brehm, P. (2003) Optical measurements of presynaptic release in mutant zebrafish lacking postsynaptic receptors. Journal of Neuroscience 23:10467 - 10474.

Nakajo, K., Katsuyama, Y., Ono, F., Ohtsuka, Y., and Okamura, Y. (2003) Primary structure, functional characterization and developmental expression of the ascidian Kv4-class potassium channel. Neuroscience Research 45:59-70.

Ono, F., Shcherbatko, A., Higashijima, S., Mandel, G., and Brehm, P. (2002) The zebrafish motility mutant "twitch once" reveals new roles for rapsyn in synaptic function. Journal of Neuroscience 22:6491-8.

Okada, T., Katsuyama, Y., Ono, F., and Okamura, Y. (2002) The development of three identified motor neurons in ascidian embryo. Developmental Biology 244:278-92.

Ono, F., Higashijima, S., Shcherbatko, A., Fetcho, J.R., and Brehm, P. (2001) Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse. Journal of Neuroscience 21:5439-5448.

Shchberbatko, A., Ono, F., Mandel, G., and Brehm, P. (1999) Voltage-dependent sodium channel function is regulated through membrane mechanics. Biophysical Journal 77:1945-1959.

Ono, F., Katsuyama, Y., Nakajo, K., and Okamura, Y. (1999) Subfamily-specific posttranscriptional mechanism underlies K+ channel expression in a developing neuronal blastomere. Journal of Neuroscience 19:6874-6886.

Okamura, Y., Ono, F. and Okagaki, R. (1997) Regulation of voltage-gated ion channels during ascidian embryogenesis. Developmental Neuroscience 19:23-24.

Okamura, Y., Ono, F. and Okagaki, R. (1996) Regulation of sodium channel gene expression by cell-specific interactions in the Ascidian embryo. Basic Neuroscience in Invertebrates 21-30.

Okamura, Y.,  Ono, F., Okagaki, R., Chong, J.A., and Mandel, G. (1994) Neural expression of a sodium channel gene requires cell-specific interactions. Neuron 13:937-948.

 

Invited talks

Neuroscience Research Institute, Tsukuba, Japan, June 2002

University of Connecticut Health Center, Farmington, CT, December 2002

University of Florida, St Augustine & Gainesville, FL, March 2003

FASEB summer conference "Ion Channel Regulation", Tucson, AZ, June 2003

Neuroscience Research Institute, Tsukuba, Japan, June 2004

National Institute of Physiological Sciences, Okazaki, Japan, June2004

NIH/NIAAA, Rockville, MD, September 2005

Kobe University, Kobe, Japan, July 2006

NICHD, Bethesda, MD, Dec 2009

NIEHS, Research Triangle Park, NC, June 2010

Association of Japanese life scientists (Kinyokai), Bethesda, MD, June 2010

University of Massachusetts, Amherst, MA, February 2012

Pennsylvania State University, Hershey, PA, April 2012

NeuroTalk-2012, Beijing, China (Session co-chair), May 2012

10th International Conference on Zebrafish Development and Genetics, Madison, WI, June 2012

2012 Ion Channel Retreat, Vancouver, Canada, June 2012

University of Rochester, Rochester, NY, Nov 2012

University of Miami, Miami, FL, April 2013

IDARS International Meeting, Mexico City, Mexico (Session co-organizer), April 2013