Pal Pacher M.D, Ph.D., F.A.P.S., F.A.H.A., F.A.C.C.
Chief, Section on Oxidative Stress and Tissue Injury,
Laboratory of Physiologic Studies,
National Institute on Alcohol Abuse and Alcoholism
National Institutes of Health
5625 Fishers Lane, MSC-9413, room 2N-17
Rockville, Maryland 20852, USA.
Phone: (301) 443-4830
Cell: (301) 728-7841
Fax: (301) 480.0257
E-mail: pacher@mail.nih.gov

Pal Pacher M.D, Ph.D., F.A.P.S., F.A.H.A., F.A.C.C.

Pal Pacher's CV, June 2012

 Mission Statement

The Section on Oxidative Stress Tissue Injury (SOSTI) examines the role of oxidative/nitrosative stress, inflammation, and their downstream effector pathways (e.g. nuclear enzyme Poly(ADP-ribose)polymerase 1 (PARP-1) in various forms of cardiovascular and other pathologies including those that may be affected by chronic alcohol intake or develop as a consequence of cardiovascular aging and diabetes mellitus, and identifies novel therapeutic targets to conteract these pathological processes and the consequent tissue injury. The preferred approach is to use a combination of state-of-the-art in vivo methodologies to analyze hemodynamic functions in combination with cell and molecular biological methods to study the expression and function of cellular proteins, lipid mediators involved in tissue injury and inflammation, or acting as anti-inflammatory, protective and tissue repair mechanisms. As an example for the latter, the role of endocannabinoids as potential anti-inflammatory mediators acting via CB2 cannabinoid receptors in peripheral tissues is analyzed in ischemia-reperfusion models of organ injury, and cardiovascular inflammation/aging.

Current Staff:

Partha Mukhopadhyay, PhD, Staff scientist, E-mail: mpartha@mail.nih.gov

Partha Mukhopadhyay, Ph.D.

Zongxian Cao, MD, PhD, IRTA Fellow, E-mail: zongxian.cao@nih.gov

Zongxian Cao, MD, Ph.D.

Katalin Erdelyi PhD, Visiting Research Fellow, E-mail: katalin.erdelyi@nih.gov

Katalin Erdelyi, PhD

Wen-Shin Lee, MD, guest researcher (supported by hospital funds from Taiwan), E-mail: wen-shin.lee@nih.gov

Wen-Shin Lee, MD

Enkui Hao, MD, guest researcher (supported by hospital funds from China), E-mail: enkui.hao@nih.gov

Enkui Hao, MD

Section alumni

Visiting Fellows:
- Rajesh Mohanraj Ph.D, currently Assistant Professor, UAE University
- Sandor Batlkai MD, PhD, currently, group leader, University of Hannover 

Guest researchers:
- Hao Pan, MD, currently nephrologist in China
- Enrique Guerrero-Beltrán, PhD, currently Postdoctoral Fellow, Universidad Nacional Autónoma de México
- Bela Horvath, MD, PhD, guest researcher (supported by Hungarian NIH), currently Pathology Resident, Cleveland Clinic
  E-mail: horvath_bela_andras@yahoo.com

Summer students/special volunteers:
- Lucja Flis, currently college student
- Nora Czifra, currently college student
- Lauren Becker, currently college student
- Vivek Patel, currently college student
- Racheal Y. Gao, currently college student
- Galin Tanchian, currently college student
- Malek Kechrid, currently college student

 

Collaborators

David Wink Ph.D.; Senior Investigator, NCI, Radiology Branch
http://ccr.cancer.gov/staff/staff.asp?profileid=5558

Murali Krishna Cherukuri Ph.D.; NCI, Radiology Branch
http://ccr.cancer.gov/staff/staff.asp?profileid=5555

George Kunos M.D., Ph.D.; Scientific Director, NIAAA/NIH;
http://www.niaaa.nih.gov/research/niaaa-intramural-program/niaaa-laboratories/laboratory-physiologic-studies/lps-section

Byoung Song PhD; Senior Investigator, Unit of Molecular Biology, NIAAA/NIH;
http://www.niaaa.nih.gov/research/niaaa-intramural-program/niaaa-laboratories/laboratory-membrane-biochemistry-and-biophysi-1

Esther M. Sternberg M.D., Director Integrative Neural Immune Program Section on Neuroendocrine Immunology & Behavior, NIMH/NIH; http://www.esthersternberg.com/

Bin Gao M.D., Ph.D; Senior Investigator, Laboratory of Liver Disease, NIAAA/NIH;
http://www.niaaa.nih.gov/research/niaaa-intramural-program/niaaa-laboratories/laboratory-of-liver-diseases

Ted Usdin Ph.D.; Senior Investigator, Laboratory of Genetics, National Institute of Mental Health
http://neuroscience.nih.gov/lab.asp?org_id=175

Michael J. Iadarola, M.D., Ph.D., Senior Investigator, Neuronal Gene Expression Unit Pain and Neurosensory Mechanisms Branch, NIDCR
http://neuroscience.nih.gov/Lab.asp?Org_ID=322

Prof. Benjamin F. Cravatt, Ph.D., Director, Departments of Cell Biology and Chemistry, The Scripps Research Institute, La Jolla, CA; USA;
http://www.scripps.edu/research/faculty/cravatt

Daniel Nomura, Ph.D. University of California at Berkeley
http://nst.berkeley.edu/faculty/nomura.html

Prof Ken Mackie M.D., Department of Psychological and Brain Sciences and Program in Neuroscience;
http://www.indiana.edu/~gillctr/mackie.shtml

Prof. Lucas Liaudet M.D., Critical Care Division, Department of Internal Medicine, University Hospital, Lausanne, Switzerland;

Prof Csaba Szabo M.D., Ph.D.; The University of Texas Medical Branch, Galveston;
http://anesthesia.utmb.edu/faculty/bios/Szabo.html

Associate Prof. Zoltan Ungvari M.D., Ph.D., University of Oklahoma Health Sciences Center, USA;
http://www.ouhsc.edu/graduate/GPiBS_Mentors/biosketches/pdf/ungvari,%20zoltan.pdf

Prof. Irina Obrosova Ph.D.; Division of Nutrition and Chronic Disease; Pennington Biomedical Research Center; Louisiana State University, Baton Rouge, LA 70808;
http://www.pbrc.edu/the-center/faculty/?EmployeeID=2121

Gyorgy Hasko M.D., Ph.D; Department of Surgery, UMD NJ-New Jersey Medical School, Newark, New Jersey;
http://njms.umdnj.edu/resource_locator/find_people/profile.cfm?mbmid=haskoge

Prof. Rohini Kuner; University of Heidelberg, Germany
http://www.hbigs.uni-heidelberg.de/cv_faculty/cv_kuner.pdf

Stefan Engeli and Jens Jordan M.D., Ph.D.; University of Hannover, Germany; 
http://www.sica-hf.com/en/medizinische-hochschule-hannover.php

Sandor Batkai M.D., Ph.D., University of Hannover, Germany
http://www.mh-hannover.de/22057.html

Prof. Roger Pertwee Ph.D., University of Aberdeen, UK
http://www.abdn.ac.uk/ims/staff/details.php?id=rgp

Dr. Isaac E. Stillman MD, Department of Pathology, Beth Israel Deaconess Medical Center
http://services.bidmc.org/Find_a_doc/doc_detail.asp?sid=41414547464840

Prof. Aristidis Veves M.D., Ph.D, Beth Israel Deaconess Medical Center, Boston, MA
http://connects.catalyst.harvard.edu/profiles/profile/person/18929

Professor David Kass; Johns Hopkins Medical Institutions
http://www.hopkinsmedicine.org/heart_vascular_institute/experts/physician_profile/9C8C7D92C0E080EAE24751C2DCFBF5B1/David_Kass,%20MD

Prof.  Aron Lichtman Ph.D., VCU
http://www.people.vcu.edu/~alichtma/index.htm                                                                                                                              

Prof. Raphael Mechoulam Ph.D.; Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty
http://paincenter.huji.ac.il/mechoulam.htm 
http://en.wikipedia.org/wiki/Raphael_Mechoulam 

 

Ten recent key publications

P Pacher, Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system? Progress in Lipid Research 2011;50(2):193-211. http://www.ncbi.nlm.nih.gov/pubmed/21295074

M.Rajesh, S. Batkai, M. Kechrid, P.Mukhopadhyay, W-S. Lee, B. Horvath, E.Holovac, R.Cinar, L. Liaudet, K.Mackie, G.Hasko, P.Pacher. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation and fibrosis in diabetic cardiomyopathy. Diabetes 2012 Mar;61(3):716-27.

http://www.ncbi.nlm.nih.gov/pubmed/22315315

M Rajesh, P Mukhopadhyay, S Bátkai, V Patel, K Saito, S Matsumoto, Y Kashiwaya, B Horváth, B Mukhopadhyay, L Becker, G Haskó, L Liaudet, DA Wink, A Veves, R Mechoulam, P Pacher. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy J Am Coll Cardiol. 2010 Dec; 56(25): 2115-2125.
 http://www.ncbi.nlm.nih.gov/pubmed/21144973

P Mukhopardhyay, M Rajesh, H Pan, V Patel, B Mukhopadhyay, S Bátkai, B Gao, G Haskó, P Pacher. Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress and cell death in nephropathy. Free Radic Biol Med. 2010; Febr 48 (3): 457-467. http://www.ncbi.nlm.nih.gov/pubmed/19969072

P Mukhopadhyay, M Rajesh, S Bátkai, V Patel, Y Kashiwaya, L Liaudet, OV Evgenov, K Mackie, G Haskó, P Pacher. CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. Cardiovasc Res.  2010 Mar 1;85(4):773-84.
http://www.ncbi.nlm.nih.gov/pubmed/19942623

P Pacher, T Nagayama, P Mukhopadhyay, S Bátkai & DA Kass. Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats. Nature Protocols 2008; 3, 1422-1434.http://www.ncbi.nlm.nih.gov/pubmed/18772869

P Mukhopadhyay, S Bátkai, M Rajesh, N Czifra, J Harvey-White, G Haskó, Z Zsengeller, NP Gerard, L Liaudet, G Kunos, P Pacher. Pharmacological inhibition of cannabinoid receptor-1 protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol. Aug 2007; 50: 528 - 536.  http://www.ncbi.nlm.nih.gov/pubmed/17678736

Editorial highlight: Fajardo G, Bernstein D. Endocannabinoid inhibition: a new cardioprotective strategy against doxorubicin cardiotoxicity. J Am Coll Cardiol. 2007 Aug 7;50(6):537-9. http://www.ncbi.nlm.nih.gov/pubmed/17678737

S Bátkai, D Osei-Hyiaman, M Rajesh, H Pan, P Mukhopadhyay, J Harvey-White, JW. Huffman, B Gao, G Kunos, P Pacher. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J. 2007 Jun;21(8):1788-800. http://www.ncbi.nlm.nih.gov/pubmed/17327359

P Pacher, L Liaudet, JS Beckman. Nitric oxide and peroxynitrite in health and disease. Physiological Reviews 2007; 87:315-424. http://www.ncbi.nlm.nih.gov/pubmed/17237348

(Cover highlight; ISI:hot paper/highly cited http://www.the-aps.org/publications/prv/covers/2007/Jan%202007_PRV_Cover.pdf

ISI:hot paper/highly cited in biochemistry/biology).

Editor’s pick for the hottest paper in 2008, 2009, 2010, 2011 

P Pacher, S Batkai, G Kunos. The endocannabinoid system as an emerging target for pharmacotherapy. Pharmacological Reviews 2006; Sept; 58(3): 389-462 (ISI: fast breaking paper in pharmacology).
http://www.ncbi.nlm.nih.gov/pubmed/16968947

 

Additional selected publications (from over 200) 

B Horvath, P Mukhopadhyay, G Hasko, P Pacher. The endocannabinoid system: plant-derived cannabinoids in diabetes and diabetic complications. Am J Pathology 2012 Feb;180(2):432-42
http://www.ncbi.nlm.nih.gov/pubmed/22155112

G Hasko, P Pacher. Regulation of macrophage function by adenosine. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):865-9 http://www.ncbi.nlm.nih.gov/pubmed/22423038

B Horvath, P Mukhopadhyay, M Kechrid, V Patel, G Tanashian, DA Wink, J Gertsch, P Pacher. β-caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor dependent manner. Free Radic Biol Med. 2012 Apr 15;52(8):1325-33. http://www.ncbi.nlm.nih.gov/pubmed/22326488

P Mukhopadhyay, B Horváth, Z Zsengellér, J Zielonka, G Tanchian, E Holovac, M Kechrid, V Patel, IE Stillman, SM Parikh, J Joseph, B Kalyanaraman, P Pacher. Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med. 2012 Jan 15;52(2):497-506.

http://www.ncbi.nlm.nih.gov/pubmed/22120494

B. El-Remessy, M. Rajesh, P. Mukhopadhyay, B. Horváth, V. Patel, M. M. H. Al-Gayyar, B. A. Pillai and P Pacher. Cannabinoid 1 receptor activation contributes to the vascular inflammation and cell death in diabetic retinopathy. Diabetologia 2011;54(6):1567-78. http://www.ncbi.nlm.nih.gov/pubmed/21373835

P Mukhopadhyay, B Horváth, M Rajesh, S Matsumoto, K Saito, S Bátkai, V Patel, G Tanchian, RY Gao, BF Cravatt, G Haskó, P Pacher. Fatty acid amide hydrolase is a key regulator of the endocannabinoid-induced myocardial tissue injury. Free Radic Biol Med. 2011;50(1):179-95. http://www.ncbi.nlm.nih.gov/pubmed/21070851

P Mukhopadhyay, B Horváth, M Kechrid, G Tanchian, M Rajesh, AS Naura, AH Boulares, P Pacher. 2. Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury. Free Radic Biol Med. 2011 Nov 1;51(9):1774-88. [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/21884784
 
P Mukhopadhyay, M  Rajesh, B Horváth, S Bátkai, O Park, O Tanashian, RY Gao, V Patel, DA Wink, L Liaudet, G Haskó, R Mechoulam, P Pacher. Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death. Free Radic Biol Med. 2011 50(10):1368-81. http://www.ncbi.nlm.nih.gov/pubmed/21362471

B Horvath, L Magid, M Partha, B Sandor, M Rajesh, O Park, G Tanchian, R Gao, C Goodfellow, M Glass, R Mechoulam, P Pacher. A new cannabinoid 2 receptor agonist HU-910 attenuates oxidative stress, inflammation, and cell death associated with hepatic ischemia/reperfusion injury. Br J Pharmacol. 2012 Apr;165 (8):2462-2478. http://www.ncbi.nlm.nih.gov/pubmed/21449982

B Sandor, M Partha, B Horvath, M Rajesh, R Gao, A Mahadeva, M Amere, N Battista, A Lichtman, L Gauson, M Maccarrone, R Pertwee, P Pacher. Δ8-Tetrahydrocannabivarin protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress and inflammatory response involving CB2 receptors. Br J Pharmacol. 2012 Apr;165(8):2450-2461. http://www.ncbi.nlm.nih.gov/pubmed/21470208

J-P Stasch, P Pacher, Evgenov O. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary diseases. Circulation 2011;123(20):2263-73.  http://www.ncbi.nlm.nih.gov/pubmed/21606405

B Csóka, Z Selmeczy, B Koscsó, ZH Németh, P Pacher, PJ Murray, D Kepka-Lenhart, SM. Morris, Jr., WC Gause, SJ Leibovich, and G Haskó. Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J. 2012 Jan;26(1):376-86. http://www.ncbi.nlm.nih.gov/pubmed/21926236

Csóka B, Németh ZH, Rosenberger P, Eltzschig HK, Spolarics Z, Pacher P, Selmeczy Z, Koscsó B, Himer L, Vizi ES, Blackburn MR, Deitch EA, Haskó G. A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation. J Immunol. 2010 Jul 1;185(1):542-50. http://www.ncbi.nlm.nih.gov/pubmed/20505145

N Horiguchi, M Andrew, W Hua, F Lafdil, M Rajesh, P Mukhopadhyay, P Ogyi,  P Pacher, B Gao. Dissociation of liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific STAT3 knockout mice. Hepatology 2010, May;51(5):1724-34. http://www.ncbi.nlm.nih.gov/pubmed/20196117
 
L Himer, B Csóka, Z Selmeczy, B Koscs, T Pócza, P Pacher, ZH Németh, EA Deitch, ES Vizi, BN Cronstein, G Haskó. Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J. 2010 Aug;24(8):2631-40. http://www.ncbi.nlm.nih.gov/pubmed/20371613
   
Rolli J, Rosenblatt-Velin N, Li J, Loukili N, Levrand S, Pacher P, Waeber B, Feihl F, Ruchat P, Liaudet L. Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. PLoS One. 2010 Sep 13;5(9):e12687. http://www.ncbi.nlm.nih.gov/pubmed/20856884

N Loukili, N Rosenblatt-Velin N, J Rolli, S Levrand, F Feihl, B Waeber, P Pacher, L Liaudet. Oxidants positively or negatively regulate nuclear factor kappa B in a context-dependent manner. J Biol Chem. May 21;285(21):15746-52. http://www.ncbi.nlm.nih.gov/pubmed/20299457

P Mukhopadhyay, H Pan, M Rajesh, S Bátkai, V Patel, J Harvey-White, B Mukhopadhyay, G Haskó, B Gao, K Mackie, P Pacher. CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. Br J Pharmacol 2010 Jun;160(3):657-68. http://www.ncbi.nlm.nih.gov/pubmed/20590569

M Rajesh, P Mukhopadhyay, G Haskó, L Liaudet, K Mackie, P Pacher. Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent MAPK activation and cell death in human coronary artery endothelial cells. Br J Pharmacol 2010 Jun;160(3):688-700. http://www.ncbi.nlm.nih.gov/pubmed/20590572

Csiszar A, Labinskyy N, Pinto J, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, P Pacher, Zhang C, Ungvari Z. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 2009;297(1):H13-20.  http://www.ncbi.nlm.nih.gov/pubmed/19429820

Labinskyy N, Mukhopadhyay P, Pinto J, Ballabh P, Zhang C, P Pacher, Csiszar A, Ungvari Z. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol 2009;297(5):H1876-81.  http://www.ncbi.nlm.nih.gov/pubmed/19749157

Madesh M, Zong WX, Hawkins BJ, Ramasamy S, Venkatachalam T, Mukhopadhyay P, Doonan PJ, Irrinki KM, Rajesh M, P Pacher, Thompson CB. Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol. 2009;29(11):3099-112.  http://www.ncbi.nlm.nih.gov/pubmed/19332555

B Csóka, ZH Németh, P Mukhopadhyay, Z Spolarics, M Rajesh, S Federici, EA Deitch, S Bátkai, P Pacher, G Haskó. CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis. (co-corresponding Author/PI) PLoS One. 2009 Jul 29;4(7):e6409. http://www.ncbi.nlm.nih.gov/pubmed/19641602

Sovershaev MA, Egorina EM, Hansen JB , Østerud B, P Pacher, Stasch JP, and Evgenov OV. Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor. Arterioscler Thromb Vasc Biol. 29(10):1578-86, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19592462

Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Hasko G, P Pacher. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation and cell death. J Pharmacol Exp Ther. 2009; 328(3):708-14. http://www.ncbi.nlm.nih.gov/pubmed/19074681

P Pacher. Cannabinoid CB1 receptor antagonists for atherosclerosis and cardiometabolic disorders: new hopes, old concerns? Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):7-9. http://www.ncbi.nlm.nih.gov/pubmed/19092136

Rajesh M, Mukhopadhyay P, Bátkai S, Mukhopadhyay B, Patel V, Haskó G, Szabó C, Mabley JG, Liaudet L, P Pacher.  Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy. J Cell Mol Med DOI: Aug;13(8B):2330-41, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19175688

P Mukhopadhyay, Rajesh M, S Bátkai, K Yoshihiro, G Haskó, L Liaudet, C Szabó and P Pacher. Role of superoxide, nitric oxide and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1466-83. http://www.ncbi.nlm.nih.gov/pubmed/19286953
Highlight  in the SFRBM newsletter: http://www.sfrbm.org/pdf/DotSpring2009.pdf

P Pacher, Steffens S. The emerging role of the endocannabinoid system in cardiovascular disease. Semin Immunopathol. 2009 Jun;31(1):63-77. http://www.ncbi.nlm.nih.gov/pubmed/19357846

Liaudet L, Vassalli G, P Pacher. Role of peroxynitrite in the redox regulation of cell signal transduction pathways. Front Biosci. 2009 Jan 1;14:4809-14. http://www.ncbi.nlm.nih.gov/pubmed/19273391

Biro T, Toth BI, Hasko G, Paus R, P Pacher. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends in Pharmacological Science  2009;30(8):411-20 (Cover highlight). http://www.ncbi.nlm.nih.gov/pubmed/19608284

G Hasko, B Csoka, ZH Nemeth, ES Vizi, and  P Pacher. A2B adenosine receptors in immunity and inflammation. Trends in Immunology 2009 Jun;30(6):263-70. http://www.ncbi.nlm.nih.gov/pubmed/19427267

P Pacher. Editor of the special issue of FRONTIERS IN BIOSCIENCE ”NITRIC OXIDE, SUPEROXIDE AND PEROXYNITRITE IN CARDIOVASCULAR DISEASES” with 1998 Nobel Laureate Prof. Ferid Murad
http://www.bioscience.org/home/special/pacherp.htm

N Horiguchi, L Wang, P Mukhopadhyay, O Park, WI Jeong, F Lafdil, D Osei-Hyiaman, A Moh, XY Fu, P Pacher, G Kunos, B Gao. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology. 2008;134(4):1148-58. http://www.ncbi.nlm.nih.gov/pubmed/18395093

P Pacher, K Sharma, G Csordás, Y Zhu, G Hajnoczky. Uncoupling of ER-Mitochondrial Calcium Communication by Transforming Growth factor-{beta}Am J Physiol Renal Physiol. 2008;295(5):F1303-12.
http://www.ncbi.nlm.nih.gov/pubmed/18653477
Editorial highlight: http://www.ncbi.nlm.nih.gov/pubmed/18768586

Csóka B, Himer L, Selmeczy Z, Vizi ES, P Pacher, Ledent C, Deitch EA, Spolarics Z, Németh ZH, Haskó G. Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function. FASEB J. 2008;22(10):3491-9. http://www.ncbi.nlm.nih.gov/pubmed/18625677

Rajesh M, Mukhopadhyay P, Haskó G, Huffman JW, Mackie K, P Pacher. CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration. Br J Pharmacol. 2008;153(2):347-57. http://www.ncbi.nlm.nih.gov/pubmed/17994109

M Rajesh, P Mukhopadhyay, G Haskó, P Pacher. Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation. Biochem Biophys Res Commun. 2008 26;377(4):1248-52. http://www.ncbi.nlm.nih.gov/pubmed/18996082

KH Moon, BL Hood, P Mukhopadhyay, R Mohanraj, MA Abdelmegeed, YI Kwon, TP Conrads, TD Veenstra, BJ Song, P Pacher. Oxidative Inactivation of Key Mitochondrial Proteins Leads to Dysfunction and Injury in Hepatic Ischemia Reperfusion.Gastroenterology. 2008;135(4):1344-57.  http://www.ncbi.nlm.nih.gov/pubmed/18778711

Haskó G, P Pacher. A2A receptors in inflammation and injury: lessons learned from transgenic animals. J Leukoc Biol. 2008;83(3):447-55.  http://www.ncbi.nlm.nih.gov/pubmed/18160539

P Pacher, B Gao. Endocannabinoid Effects on Immune Cells: Implications for Inflammatory Liver Diseases. Am J Physiol Gastrointest Liver Physiol. 2008;294(4):G850-4. http://www.ncbi.nlm.nih.gov/pubmed/18239059

P Pacher, Haskó G. Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning. Br J Pharmacol. 2008;153(2):252-62.  http://www.ncbi.nlm.nih.gov/pubmed/18026124

P Pacher, P Mukhopadhyay, M Rajesh, S Bátkai, G Kunos. Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential. Hypertension 2008 Oct;52(4):601-7.  http://www.ncbi.nlm.nih.gov/pubmed/18779440

 P Pacher, C Szabo. Role of peroxynitrite and PARP in human diseases. Am J Pathology. 2008;173(1):2-13.
http://www.ncbi.nlm.nih.gov/pubmed/18535182

G Hasko, J Linden, B Cronstein, P Pacher. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nature Reviews Drug Discovery 2008 Sep;7(9):759-70. http://www.ncbi.nlm.nih.gov/pubmed/18758473

N Agarwal, P Pacher, F Amaya, C Constantin, G Brenner, C Michalski,  I Tegeder, G Marsicano, C Marian, S Batkai, MJ Fischer, P Reeh, G. Kunos, B Lutz, M Kress, C J Woolf, R Kuner. Cannabinoids induce analgesia primarily via CB1 receptors on peripheral nociceptive neurons. Nature Neurosci. 2007;10(7):870-9. http://www.ncbi.nlm.nih.gov/pubmed/17558404

B Csóka, ZH Nemeth, L Virag, P Gergely, SJ Leibovich, P Pacher, ES Vizi, EA Deitch, G Hasko. Adenosine receptor activation ameliorates type 1 diabetes. A2A adenosine receptors and C/EBPbeta are crutially required for IL-10 production by macrophages exposed to E. coli. Blood 2007; 110(7):2685-95. http://www.ncbi.nlm.nih.gov/pubmed/17525287

ZH Nemeth, D Bleich, B Csóka, P Pacher, JG Mabley, ES Vizi, EA Deitch, C Szabo, G Hasko. Adenosine receptor activation ameliorates type 1 diabetes. FASEB J. 2007; 21:2379-2388.   http://www.ncbi.nlm.nih.gov/pubmed/17405852

CW Michalski, T Laukert, P Pacher, N Agarwal, F Bergmann, Y Su, S Bátkai, H Friess and R Kuner. Cannabinoids ameliorate pain and reduce disease pathology in acute pancreatitis in the absence of central side-effects. Gastroenterology 2007;132(5):1968-78. http://www.ncbi.nlm.nih.gov/pubmed/17484889

M Rajesh, P Mukhopadhyay, S Batkai, G Hasko, L Liaudet, JW Huffman, A Csiszar, ZI Ungvari, K Mackie, S Chatterjee, and P Pacher. Cannabinoid-2 receptor stimulation attenuates TNF -induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol, 2007;293(4):H2210-8. http://www.ncbi.nlm.nih.gov/pubmed/17660390

M Rajesh, P Mukhopadhyay, S Batkai, G Hasko, L Liaudet, VR Drel, IG Obrosova, P Pacher. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am J Physiol Heart Circ Physiol. 2007;293(1):H610-9.  http://www.ncbi.nlm.nih.gov/pubmed/17384130

Batkai S, Rajesh M, Mukhopadhyay P, Hasko G, Liaudet L, Cravatt BF, Csiszar A, Ungvari ZI, P Pacher. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression and apoptosis in mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol. 2007; 293(2):H909-18. http://www.ncbi.nlm.nih.gov/pubmed/17434980

Mukhopadhyay P, Rajesh M, Kashiwaya Yoshihiro, Hasko G, P Pacher. Simple quantitative detection of mitochondrial superoxide formation in live cells. Biochem Biophys Res Commun 2007;22;358(1):203-8. http://www.ncbi.nlm.nih.gov/pubmed/17475217

M Rajesh, H Pan, P Mukhopadhyay, S Bátkai, D Osei-Hyiaman, G Haskó, L Liaudet, B Gao, P P Pacher. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response and apoptosis. Journal of Leukocyte Biology 2007;82(6):1382-9. http://www.ncbi.nlm.nih.gov/pubmed/17652447
Cover highlight, interview: http://www.ncbi.nlm.nih.gov/pubmed/18040082

P Mukhopadhyay, M Rajesh, G Haskó, BJ. Hawkins, Madesh M, P Pacher. Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nature Protocols 2007;2(9):2295-301.  http://www.ncbi.nlm.nih.gov/pubmed/17853886

P Pacher and C Szabo. Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. Cardiovasc Drug Rev. 2007;25(3):235-60.  http://www.ncbi.nlm.nih.gov/pubmed/17919258

Milman G, Maor Y, Abu-Lafi S, Horowitz M, Gallily R, Batkai S, Mo FM, Offertaler L, P Pacher, Kunos G, Mechoulam R. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proc Natl Acad Sci U S A. 2006;103(7):2428-33. http://www.ncbi.nlm.nih.gov/pubmed/16467152

ZH Németh, B Csóka, J Wilmanski, D Xu, Q Lu, C Ledent, EA Deitch, P Pacher, Z Spolarics, and G Haskó. Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis. J Immunol 2006; 176(9):5616-5626.  http://www.ncbi.nlm.nih.gov/pubmed/16622031

S Levrand, C Vannay-Bouchiche; B Pesse, P Pacher, F Feihl, B Waeber, L liaudet. Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo. Free Radical Biology and Medicine 2006;41(6):886-95. http://www.ncbi.nlm.nih.gov/pubmed/16934671

M Blüher, S Engeli, N Klöting, J Berndt, M Fasshauer,  S Bátkai, P Pacher, MR Schön, J Jordan, M Stumvoll. Dysregulation of the Peripheral and Adipose-Tissue Endocannabinoid System in Human Abdominal Obesity Diabetes 2006;55(11):3053-60.  http://www.ncbi.nlm.nih.gov/pubmed/17065342

M Rajesh, P Mukhopadhyay, G Godlewski, S Bátkai, G Haskó, L Liaudet and P Pacher. Poly(ADP-ribose) polymerase inhibition decreases angiogenesis. BBRC 2006; 350(4):1056-1062. http://www.ncbi.nlm.nih.gov/pubmed/17046715

VR Drel, P Pacher, MJ Stevens and IG Obrosova. Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells. Free Radical Biology and Medicine 2006; 40(8):1454-1465. http://www.ncbi.nlm.nih.gov/pubmed/16631535

O Ilnytska, VV Luzogubov, MJ Stevens, VR Drel, N Mashtalir, P Pacher, MA Yorek, IG Obrosova. Poly(ADP-ribose) polymerase inhibition alleviates experimental sensory neuropathy. Diabetes; 55(6):1686-1694. http://www.ncbi.nlm.nih.gov/pubmed/16731831

O Evgenov, P Pacher, PM Schmidt, G Hasko, HW Schmidt, J-P Stasch. Nitric-oxide independent stimulators of soluble guanylate cyclase: Development and therapeutic potential. Nature Reviews Drug Discovery 2006;5(9):755-768. http://www.ncbi.nlm.nih.gov/pubmed/16955067

C Szabo, P Pacher, RA Swanson. Novel modulators of poly(ADP)polymerase. Trend Pharmacol Sciences 2006; 27(12):626-630. http://www.ncbi.nlm.nih.gov/pubmed/17055069

P Pacher, C Szabo. Role of Peroxynitrite in the Pathogenesis of Cardiovascular Complications of Diabetes. Current Opinion in Pharmacology 2006;6(2):136-41. http://www.ncbi.nlm.nih.gov/pubmed/16483848

P Pacher, A Nivorozhkin, C Szabo. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacological Reviews 2006;58:87-114. http://www.ncbi.nlm.nih.gov/pubmed/16507884

D Osei-Hyiaman, M DiPetrillo, P Pacher, S Radaeva, J Liu, J Harwey-W, S Batkai,L Offertaler, G Kunos. "Cannabinoid Regulation of Fatty Acid Synthesis. Links Peripheral Metabolic and Central Appetitive Mechanisms. JCI 2005;115(5):1298-1305. http://www.ncbi.nlm.nih.gov/pubmed/15864349

IG Obrosova, VR Drel, P Pacher, O Ilnytska, ZQ Wang, MJ Stevens, MA Yorek. Oxidative-nitrosative stress and PARP activation in experimental diabetic neuropathy: the relation is revisited.  Diabetes 2005;54(12):3435-4341.
http://www.ncbi.nlm.nih.gov/pubmed/16306359

S Engeli, J Böhnke, M Feldpausch, K Gorzelniak, J Janke, S Bátkai, P Pacher, FC Luft, AM Sharma, J Jordan. Activation of the Peripheral Endocannabinoid System in Human Obesity. Diabetes. 2005;54(10):2838-2843.
http://www.ncbi.nlm.nih.gov/pubmed/16186383

Z Nemeth, CS Lutz, B Csoka, EA Deitch, SJ Leibovich, WC Gause, M Tone, P Pacher, ES Vizi, G Hasko. Adenosine augments interleukin-10 production by macrophages through an A2B receptor-mediated post-transcriptional mechanism. J Immunulogy 2005;175(12):8260-70. http://www.ncbi.nlm.nih.gov/pubmed/16339566

IG Obrosova, P Pacher, C Szabo, Z Zsengeller, H Hirooka, MJ Stevens, MA Yorek. Aldose Reductase Inhibition Counteracts Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase Activation in Tissue Sites for Diabetes Complications. Diabetes. 2005;54(1):234-242. http://www.ncbi.nlm.nih.gov/pubmed/15616034

P Pacher & C Szabó. Role of poly(ADP-ribose) polymerase-1 (PARP)  activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme. Antioxidants & Redox Signaling 2005;7(11-12):1568-80. http://www.ncbi.nlm.nih.gov/pubmed/16356120

P Pacher, I Obrosova, JG Mabley & C Szabó. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications.  Emerging new therapeutical strategies Curr Med Chem 2005;12(3):267-275. http://www.ncbi.nlm.nih.gov/pubmed/15723618

P Pacher, R Shultz, L Liaudet, C Szabo. Nitrosative stress and pharmacological modulation of heart failure. Trends in Pharmacological Sciences 2005;26(6):302-310.  http://www.ncbi.nlm.nih.gov/pubmed/15925705

P Pacher, Batkai S, Osei-Hyiaman D, Offertaler L, Liu J, Harvey-White J, Brassai A, Jarai Z, Cravatt BF, Kunos G. Hemodynamic profile, responsiveness to anandamide and baroreflex sensitivity of mice lacking fatty acide amide hydrolase. Am J Physiol Heart Circ Physiol. 2005 289(2):H533-541. http://www.ncbi.nlm.nih.gov/pubmed/15821037 
Editorial highlight: http://www.ncbi.nlm.nih.gov/pubmed/16014613

P Pacher, S Batkai, G Kunos. Blood pressure regulation by endocannabinoids and their receptors. Neuropharmacology 2005;48(8):1130-1138. http://www.ncbi.nlm.nih.gov/pubmed/15910888

IG Obrosova, F Li, OI Abatan, K Komjáti, P Pacher, C Szabo, MJ Stevens et al. Role for poly (ADP-ribose) polymerase activation in diabetic neuropathy. Diabetes 2004;53(3):711-20.  http://www.ncbi.nlm.nih.gov/pubmed/14988256

P Pacher, S Batkai, G Kunos. Hemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. J Physiol London 2004;558(Pt 2):647-657. http://www.ncbi.nlm.nih.gov/pubmed/15121805

S Batkai, P Pacher, D Osei-Hyiaman, S Radaeva, J Liu, J Harwey-W, L Offertaler, K Mackie, MA Rudd, R Bukoski, G Kunos. Endocannabinoids acting at CB1 receptors tonically regulate cardiovascular function in hypertension. Circulation 2004;110(14):1996-2002.  http://www.ncbi.nlm.nih.gov/pubmed/15451779

Kunos G, Pacher P. Cannabinoids cool the intestine. Nature Medicine. 2004 Jul;10(7):678-9.
http://www.ncbi.nlm.nih.gov/pubmed/15229512

P Pacher, JG. Mabley, L Liaudet, A Marton, G Hasko, O Evgenov, M Kollai and C Szabó. Left ventricular pressure-volume relationship in a rat model of advanced aging-induced heart failure. Am J Physiol Heart Circulation Physiol 2004;287(5):H2132-2137. http://www.ncbi.nlm.nih.gov/pubmed/15231502

P Pacher, A Vasslin, R Benkõ, JG Mabley, L Liaudet, G Hasko, S Batkai, A Marton, M Kollai, and C Szabo. A novel ultrapotent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging. JPET 2004;311(2):485-491.  http://www.ncbi.nlm.nih.gov/pubmed/15213249

P Pacher, V Kecskemeti. Cardiovascular effects of new antidepressants and antipsychotics. Current Pharmaceutical Design Review 2004;10(20):2463-2475. http://www.ncbi.nlm.nih.gov/pubmed/15320756

P Pacher, L Liaudet, P Bai, J G. Mabley, P Kaminski, L Virág, É Szabó, Z Ungvari, MS Wollin, JT Groves, C Szabó. A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 2003;107(6):896-904. http://www.ncbi.nlm.nih.gov/pubmed/12591762

P Pacher, JG Mabley, FG Soriano, L Liaudet, K Komjati, C Szabó. Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation. Br J Pharmacol 2002; 135(6)1347-50.
http://www.ncbi.nlm.nih.gov/pubmed/11906946

P Pacher, L Liaudet, P Bai, L Virag, JG Mabley, G Haskó and C Szabó. Activation of poly(ADP-ribose) polymerase contributes to the development of doxorubicin-induced heart failure. J Pharm Exp Ther 2002, 300(3):862-867.   http://www.ncbi.nlm.nih.gov/pubmed/11861791

P Pacher, L Liaudet, JG Mabley, C Szabó. Pharmacological inhibition of poly(ADP-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. Journal of American College of Cardiology 2002, 40/5: 1006-1016.  http://www.ncbi.nlm.nih.gov/pubmed/12225730

P Pacher, L Liaudet, FG Soriano, JG Mabley, E Szabó and C Szabó. The role of poly(ADP-ribose) polymerase in the development of cardiovascular dysfunction in diabetes mellitus. Diabetes 2002, 51:514-521.
http://www.ncbi.nlm.nih.gov/pubmed/11812763

 P Pacher, AP Thomas, G Hajnoczky. Ca2+ Marks: Miniature calcium signals in single mitochondria driven by ryanodine receptors. PNAS USA, 2002, 99: 2380-2385. http://www.ncbi.nlm.nih.gov/pubmed/11854531
  
G Szabó, S Bährle, N Stumpf, K Sonnenberg, É Szabó, P Pacher, T Csont, R Schulz, TJ Dengler, L Liaudet, GJ Southan, CF Vahl, S Hagl and C Szabó. Poly (ADP-ribose) Polymerase Inhibition Reduces Reperfusion Injury after Heart Transplantation. Circ Res 2002; 11;90(1):100-6.   http://www.ncbi.nlm.nih.gov/pubmed/11786525

C Szabó, A Zanchi, K Komjáti, P Pacher, AS Krolewski, WC Quist, ES Horton, FW LoGerfo, A Veves. Poly (ADP-ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation 2002;106:2680-2686. http://www.ncbi.nlm.nih.gov/pubmed/12438293

G Soriano, P Pacher, J Mabley, L Liaudet, C Szabo. Rapid reversal of diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 2001;89(8):684-91. http://www.ncbi.nlm.nih.gov/pubmed/11597991

P Pacher & G Hajnoczky. Propagation of the apoptotic signal by mitochondrial waves. EMBO J 2001;20:4107-4121. http://www.ncbi.nlm.nih.gov/pubmed/11483514

P Pacher, G Csordás, G Hajnoczky. Quantification of calcium signal transmission from the sarco-endoplasmic reticulum to mitochondria. J Physiology (London) 2000; 529: 553-564. http://www.ncbi.nlm.nih.gov/pubmed/11118489

FIND PUBLICATIONS USING PubMed

SAMPLE Entrez PubMed Search Instructions: Search [PUBMED] for [Pacher P] "click" [GO]

FIND CITATIONS USING Google Scholar http://scholar.google.com/  enter [Pacher P] “click” [Search]

NIH Research and Training Opportunities

FIND ANNUAL REPORT PROJECTS USING NIDBResources
SAMPLE Search Instructions: Under"Option 1" click box beside each "Year" of interest, then click "Free TextSearch" - in BOX under "Enter some Keywords", type Pacher P

 

NIH Intramural Research Program website: http://irp.nih.gov

Updated: April 2012