Sharon Majchrzak-Hong

Sharon Majchrzak-HongResearch Chemist

Sharon has over 10 years of experience in the field of lipid research; including chemical and data analysis from both animal laboratory experiments and human clinical studies.  She received her BS in Biochemistry and her BA in Chemistry from the University of Rochester (Rochester, NY) in 1994 and her MS in Natural Sciences from the University of Buffalo Roswell Park Graduate Division in 2003.   Her laboratory work at the LMBB/SNN has included fatty acid chemical analysis using the techniques of gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS), solid phase extraction (SPE), high pressure liquid chromatography (HPLC) and liquid-liquid extraction.   She has also been involved in artificial rearing (AR) nutritional studies for infant rodent models. 

Her current projects for the LMBB/SNN include providing lab and data management support for our ongoing clinical protocols.  One of the trials she is working on is the NIAAA-led multi-institute collaborative randomized controlled trial titled Dietary linoleic acid regulation of omega-3 HUFA metabolism; satiety and body composition among overweight female subjects.  In this dietary study we are investigating the effects of controlled alterations in dietary omega-6 (n-6) linoleic acid (precursor to n-6 endocannabinoids) and n-3 fatty acids (precursors to n-3 endocannabinoids) on craving, satiety, behavior and body composition.  The other clinical trial she is providing support on is the Neuroimaging Omega-3 and Reward in adults with ADHD (NORAA) trial.  In the NORAA trial we are investigating the effects of omega-3 supplementation on brain reward function in adults with ADHD as well as behavioral and biochemical endpoints.

Her research interests include lipid biochemistry, nutrition and neuroscience.  She may be contacted at 301-435-4029 or sfm@mail.nih.gov.

 

 

 

Recent Publications:

  1. CE Ramsden, D Zamora, S Majchrzak-Hong, KR Faurot, SK Broste, RP Frantz, JM Davis, A Ringel, CM Suchindran, JR Hibbeln, Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73), Bmj, 353 (2016) i1246.
  2. C.E. Ramsden, A Ringel, SF Majchrzak-Hong, J. Yang, H Blanchard, D Zamora, JD Loewke, SI Rapoport, J.R. Hibbeln, J.M. Davis, BD Hammock, AY Taha, Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes?, Mol Pain, 12 (2016).
  3. CE Ramsden, D Zamora, A Makriyannis, JT Wood, JD Mann, KR Faurot, BA MacIntosh, SF Majchrzak-Hong, JR Gross, AB Courville, JM Davis, JR Hibbeln, Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress, J Pain, 16 (2015) 707-716.
  4. AY Taha, Y Cheon, KF Faurot, B Macintosh, SF Majchrzak-Hong, JD Mann, JR Hibbeln,  A Ringel, CE Ramsden. Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools. Prostaglandins Leukot Essent Fatty Acids. 2014 90(5), 151-157. doi: 10.1016/j.plefa.2014.02.003.
  5. JC Umhau, W Zhou, S Thada, J Demar, N Hussein, AK  Bhattacharjee, K Ma, S Majchrzak-Hong, P Herscovitch , N Salem, A Urish, JR Hibbeln, SC Cunnane, SI  Rapoport, J Hirvonen. Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. PloS one 2013;8(10):e75333.
  6. CE Ramsden, D Zamora, B Leelarthaepin, SF Majchrzak-Hong, KR Faurot, CM Suchindran, A Ringel, JM Davis, JR Hibbeln. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013 Feb 4;346:e8707. doi: 10.1136/bmj.e8707.
     

 

LMBB - Section on Nutrional Neuroscience   |  Lab Members