Laboratory of Neuroimaging (LNI)
National Institute on Alcohol Abuse and Alcoholism
(NIAAA)
National Institutes of Health

10 Center Drive, Room B2L124: MSC 1013

Bethesda, MD 20892-1013

 

Chief of Laboratory
Nora D. Volkow, MD
Senior Investigator, NIAAA
Director, National Institute on Drug Abuse (NIDA)
Phone: 301-443-6480
E-mail: nvolkow@nida.nih.gov

Picture of Nora Volkow

Dr. Volkow became Director of the National Institute on Drug Abuse (NIDA) at the National Institutes of Health in May 2003. In addition to her role in NIDA, she is the chief of LNI in NIAAA. Her work has been instrumental in demonstrating that drug addiction is a disease of the human brain. As a research psychiatrist and scientist, Dr. Volkow pioneered the use of brain imaging to investigate the toxic effects and addictive properties of abusable drugs. Her studies have documented changes in the dopamine system affecting, among others, the functions of frontal brain regions involved with motivation, drive, and pleasure in addiction. She has also made important contributions to the neurobiology of obesity, ADHD, and aging. Dr. Volkow has published more than 580 peer-reviewed articles and written more than 90 book chapters and non-peer reviewed manuscripts, and has also edited three books on neuroimaging for mental and addictive disorders.

What we do

LNI uses brain imaging (PET and MRI) to study the neurocircuitry that underlies the rewarding effects of drugs of abuse and of natural reinforcers and their disruption in diseases of addiction and obesity. For this purpose we study how reward circuits modulate executive function (self-control), interoception, and motivation in the normal human brain including an understanding of the role of brain dopamine signaling, functional brain network interactions and genetics. We evaluate the disruption of these interactions in addiction, morbid obesity and ADHD, which are disorders characterized by deficits in self-control and reward sensitivity. We also focus on methodological studies to advance the tools to study function of the human brain including development of PET radiotracers, which is focused on the development of ligands to map epigenetic processes, development of analytical tools to help analyze and understand the underlying physiology behind the dynamically complex patterns of brain networks.

Our Ongoing Research Protocols are

14-AA-0144 Reliability of The Human Brain Connectome

14-AA-0187 Dopamine Rhythms in Health and Addiction

14-AA-0192 Brain Inflammation and Function in Alcoholism

15-AA-0031 Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness

15-AA-0186  Development of Neuroimaging Methods to Assess the Neurobiology of Addiction

16-AA-0059 Characterization of Brain Amyloid-beta (A-beta) Retention During Wakefulness And Following Emergence From Sleep In Healthy Subjects

17-AA-0114 Brain Dopaminergic Signaling in Opioid Use Disorders (OUD)

17-AA-0152 Ketogenic Diet (KD) in Alcoholism

 

Current Staff

Picture of Sung Won (Sunny) Kim

Sung Won (Sunny) Kim, PhD
Staff Scientist
Voice: 1 (301) 496-5548
E-mail: kims8@mail.nih.gov

Sunny is an organic chemist as well as chief radiochemist of LNI.  His research focus has been on radiotracer development and its medical application using positron emission tomography (PET).  His research involves the following: 1) design or selection of suitable molecules for radiotracer guided by in vitro biological activity, 2) organic synthesis and radiochemistry for in vivo imaging, and 3) optimization of radiotracers using rodents and non-human primates for translational research to humans. Recently, he completed the in vivo pharmacological profiling of buspirone using multiple dopamine tracers, to evaluate its potential for the treatment of cocaine addiction using a D3R-prefering radiotracer called[11C]PHNO.  Since 2009, he continues his effort for in vivo imaging tool development targeting brain epigenetic biomarkers such as histone deacetylase (HDAC).  Currently, he is also interested in automation and miniaturization of radiosynthesis devices for carbon-11 precursors and compounds, to optimize radiotracer production and streamline laboratory operations.

 

Picture of Dordo Tomasi

Dardo Tomasi, PhD
Staff Scientist
Voice: 1 (301) 496-1589
E-mail: dardo.tomasi@nih.gov

Dardo is an MRI physicist with expertise in gradient coil design, functional MRI and PET imaging. His work focuses on brain metabolism, function, structure and neurochemistry in normal subjects and psychiatric populations. He is interested on novel MRI approaches to map brain function and connectivity with high temporal and spatial resolution.  Recently, Dr. Tomasi developed ultra-fast graph theory methods to compute short- and long-range functional connectivity maps from "resting-state" echo-planar imaging time series that when used in large public image databases revealed pronounced gender and aging effects on the brain's functional architecture.

Picture of Gene-Jack Wang

Gene-Jack Wang, MD
Senior Clinician & Clinical Director
Voice: 1-301-496-5012
E-mail: gene-jack.wang@nih.gov

Gene-Jack is a board certified Nuclear Medicine physician. He joined NIAAA as a senior clinician and the clinical director of LNI in 2013. Prior to his current appointment, he was a professor of Radiology at Stony Brook University, a senior scientist and chairman of medical department at Brookhaven National Laboratory. He also held a joint appointment as a professor of Psychiatry at Mount Sinai School of Medicine. His research focuses on the application of PET and functional MRI to the study of various brain disorders. He is interested in using PET to study the neuro-psychiatric mechanisms and manifestations of alcoholism, drug addiction, ADHD, obesity and eating disorder in humans. Using PET, he first reported similarity of human brain circuits’ disruption in drug addiction and in obesity. Prior to his appointment in NIH, he had obtained grant awards from Department of Energy, NIH and pharmaceutical company to support his research. As results of his imaging research, he has published 281 original articles, 45 review articles, 18 book chapters. 

Picture of Karen Torres

Karen Torres
Protocol Coordinator
Voice: 1 (301) 496-4186
E-mail: karen.torres@nih.gov

Karen joined the Laboratory of Neuroimaging (LNI) as a Clinical Protocol Coordinator in 2010. Previous to coming on board in the NIAAA/LNI, she performed the same role starting in 2003 when the NIAAA/LNI was first established at the Brookhaven National Laboratory (BNL) in Upton, NY. Karen's role as the Clinical Protocol Coordinator covers working on and managing protocols starting from inception through, scientific review, IRB submissions, IND preparation and protocol implementation. She organizes and schedules scientific seminars, presentations and talks by current lab staff as well as invited guests. In addition to these activities, she manages the NIAAA calendar for the Laboratory Chief of LNI.

 

Lori Talagala

Lori Talagala, BS
MRI Technologist
Voice: 1 (301) 496-1589
E-mail: lori.talagala@nih.gov

Lori is certified in Radiography and Magnetic Resonance Imaging by the American Registry of Radiologic Technologists (ARRT) and has been involved in MRI since 1988. Prior to working with LNI, Lori worked as a technologist and instructor at the Pittsburgh NMR Institute/University of Pittsburgh Medical Center, and was CT/MRI Supervisor at Latrobe Area Hospital. Lori served on the Practice Analysis Advisory Committee for the development of the MRI registry exam and as an item writer for the MRI registry exam. She also served as Secretary of the Section for Magnetic Resonance Technologists (SMRT).

 

Minoo McFarland

Minoo McFarland, MSN, CFNP
Nurse Practitioner
E-mail: minoo.mcfarland@nih.gov

Minoo is a board-certified Family Nurse Practitioner. She obtained her Master of Science in Nursing in 2001 from George Mason University in collaboration with the George Washington University School of Medicine. Prior to joining NIAAA she worked at Allergy Partners as a nurse practitioner caring for patients with diseases of allergy and asthma. Ms. McFarland, in past, worked at Inova Transplant Center as a transplant coordinator caring for kidney and pancreas transplant patients. Prior to that she worked at an internal medicine office. She joined LNI in January of 2017. She screens and evaluates participants and assign to different protocols. She educates the participants with the procedures and provides patient care during procedures and follow-ups. She is responsible for coordination and implementation of clinical research projects. She aids in data collection and documentation for the study. 

 

Christopher T. Wong

Christopher T. Wong, BS, CNMT
Data Manager
Voice: 1 (301) 496-4186
E-mail: chris.wong@nih.gov

 

Picture of Ehsan Shokri Kojori

Ehsan Shokri Kojori, PhD
Research Fellow
Voice: 1 (301) 451-3020
E-mail: ehsan.shokrikojori@nih.gov

Ehsan joined the lab as a postdoctoral IRTA fellow in August 2014 and became a Research Fellow in May 2016. He earned a PhD degree in cognitive neuroscience from the University of Texas at Dallas in Spring 2014. Ehsan also has a background in electrical engineering and signal processing. His interests include combining brain imaging modalities (e.g., fMRI, DTI, and PET) and behavioral measurements to understand the neurocognitive underpinnings of goal directed behavior. His current work involves studying how addiction and alcohol abuse affect efficiency and energetic cost of the brain networks. He is also working on developing novel methodologies to better characterize anatomical and functional brain connectivity indices.

 

Picture of Corinde Wiers

Corinde Wiers, PhD
Research Fellow
Voice: 301-451-3021
E-mail: corinde.wiers@nih.gov

Corinde joined the LNI as a Postdoctoral IRTA Fellow in September 2014, and became a Research Fellow in September 2016. She studied psychology and psychobiology at the University of Amsterdam (Netherlands) and Sussex University (UK), and earned her PhD in psychology from the Berlin School of Mind and Brain and Free University Berlin (Germany). Her research investigates cognitive and neurobiological processes involved in addiction, using fMRI, PET and psychophysics. She currently works on how genetic and epigenetic markers relate to brain functioning in drug abusers.

 

Min Guo

Min Guo, PhD
Post-Doctoral IRTA Fellow
Voice: 1 (301) 496-5548
E-mail: min.guo2@nih.gov

Min received his B.S. and M.S. in organic chemistry from Nanjing University, China. Then he decided to study abroad and got his Ph.D. in organic chemistry and biochemistry from University of Maryland, College Park. His Ph.D. work involved synthesis and evaluate bioactive small molecules to modulate bacteria communication. In August 2015, he joined LNI as a postdoctoral fellow under the advice of Dr. Sung Won Kim. He is interested in developing new radiotracers as diagnostic tools for neurodegenerative diseases.

 

Picture of Sukru Baris Demiral, Ph.D

Sukru Baris Demiral, PhD
Post-doctoral IRTA Fellow
Voice: (301) 402-5861
E-mail: sukru.demiral@nih.gov

Baris received his Ph.D. from the University of Leipzig, Faculty of Biosciences, Pharmacy and Psychology, Germany, through a joint project in Max Planck Institute Cognitive and Brain Sciences. He studied physics in his undergraduate studies, then conducted cognitive modeling work and neurolinguistics research in the following years. His developing interests in neurophysiology, neurotransmitter dynamics, addiction, motivation, and genetics led him to work in a number of neurophysiology labs as a post-doc. He joined LNI in early 2016, and he is currently exploring the effects of arousal, sleep, and sleep deprivation on neural dynamics, brain metabolism, and health via multi-modal imaging including fMRI, PET and simultaneous EEG-fMRI techniques.  

 

Peter Manza

Peter Manza, PhD
Postdoctoral IRTA Fellow
Voice: 1 (301) 496-5012
E-mail: peter.manza@nih.gov

Pete joined the LNI as a postdoctoral IRTA fellow in February 2017. He studied psychology and biology at the University of Rochester, and earned his PhD in integrative neuroscience from Stony Brook University in December 2016. Pete is interested in how dopamine influences cognitive control in health and neuropsychiatric disease. He is currently working on combining fMRI, PET, and genetic markers to understand neurocognitive processes in drug addiction.

 

Ryan Tyler

Ryan Tyler, BS
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 496-5548
E-mail: ryan.tyler@nih.gov

Ryan received his B.S. in Chemistry at the College of William and Mary in May 2015, and joined the Laboratory of Neuroimaging the following August.  He plans on pursuing a PhD in neuroscience, or a related field. 

 

Clara Freeman

Clara Freeman, BA
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 451-2401
E-Mail: clara.freeman@nih.gov

 
Clara received her B.A. in psychology from Cornell University in May 2016, and joined the Laboratory of Neuroimaging in the following July. She plans to pursue a PhD in clinical psychology in the future.   
 
 
 
Anna Zehra
Amna Zehra, BS
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 827-7076
E-mail: amna.zehra@nih.gov

Amna received her B.S. in Psychology from University of Maryland, College Park in May 2016 and joined the Laboratory of Neuroimaging in July 2016. Her responsibilities include screening research subjects, administering clinical interviews and neuropsychological assessments, and conducting fMRI and PET imaging sessions. Amna plans to attend medical school in the future.

 
 
 
Veronica Ramirez
Veronica Ramirez, BA
Post-baccalaureate NIH UGSP Fellow
Voice: (401) 451-1504
 
Veronica received her B.A. in Psychology from the University of San Diego. She was awarded the NIH Undergraduate Scholarship Program (UGSP) in 2014 and joined LNI as a postbac in May 2016. Her research interests include the neuromechanisms of addiction and value based decision-making. She assists in fMRI and PET study sessions, clinical interviews, neuropsychological testing, and data analyses/management. She currently works on combining actinography with neuropsychological measures to study correlations of physical activity and psychological traits. Her goal is to pursue a PhD in neuroscience/psychology and to continue doing research on brain and behavior.
 
 
Tyler Stodden
Tyler Stodden, BS
Voice: 1 (301) 496-5548
 
Tyler received his B.S. in Biological Engineering from the University of Missouri in December 2016, and has been a post-baccalaureate fellow with the LNI since March 2017. His responsibilities include radiolabeling and in vivo testing of both novel and existing radiotracers for PET imaging, reconstructing and analyzing image data, and automating routine lab operations in order to minimize exposure to radioactivity. Tyler plans to attend medical school in the future.
 
 
 
Jamie Burns
Jamie Burns, BS
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 402-0910
 
Jamie received her B.S. in biology from George Washington University in May of 2017 and joined the Laboratory of Neuroimaging the following July as a post-baccalaureate fellow. Jamie plans to attend medical school in the future.
 
 
Kure Liu
Christopher Kure Liu, BS
Post-baccalaureate IRTA Fellow
Voice: 1 (301) 451-2116
 
Christopher received his B.S. in Neuroscience from the University of California, Los Angeles in June 2017 and joined the Laboratory of Neuroimaging in July 2017. Christopher plans to attend medical school in the future.
 
 
 

Special Volunteers

Picture of Yeon Joo Jang

Yeon Joo Jang, PhD
Voice: 1 (301) 402-0910
E-mail: yeonjoo.jang@nih.gov

After getting M.S. degree in the field of molecular biology in Seoul, South Korea, Yeon worked on as a researcher to understand the molecular mechanisms of Parkinson’s disease by using both cellular system and in vivo system. To pursuit Ph. D degree in United States, Yeon studied on molecular mechanisms driven by oncogene induced signaling pathway in SUNY, State Univ. of New York in Stony Brook. Currently she is helping to understand the mechanism of Alcohol induced neuroinflammation with biological tools.

 

Picture of Yeon Joo Jang

Kenny Ke, BS
E-mail: Kenneth.ke@nih.gov

Kenny received his B.S. in Bioengineering at the University of Maryland at College Park in May 2016 and is currently pursuing a M.Eng. in Bioengineering also at the University of Maryland. He joined the Laboratory of Neuroimaging in June 2017 and plans on pursuing a career in biotechnology in the future.

 

Tansha Srivastava, MD
Tansha Srivastava, MD
Voice: 1 (202) 781-9928 
 
Tansha joined the Laboratory of Neuroimaging in June 2017.  She is a graduate in Health Science from University of Ontario Institute of Technology in Ontario, Canada, and earned her M.D. degree from Aureus University School of Medicine, Aruba. Tansha is currently analyzing and interpreting data for test-retest reliability of sleep measures as well as the associations between demographics and sleep stages and their potential effects on brain health. She plans to complete a residency program and become a board certified physician.
 
 
Jizheng Zhao
Jizheng Zhao, PhD
Voice: 1 (202) 781-9928 
 
Jizheng is a lecturer of North West Agriculture & Forestry University, Shaanxi, China. He joined the lab as a special volunteer in February 2016 with a support from Chinese Scholarship Council. He received PhD from Xidian University, China in Pattern Recognition and Intelligent System. His research interests focus on neural mechanisms underlying obesity bariatric surgery.
 

Walter Reed Psychiatry Resident Research Rotation

Kyle Gray, MD, PGY2 Psychiatry Resident, starting 2015

Parmalee C. Towb, MD, PhD, PGY4 Psychiatry Resident, starting 2016

Shram Shukla, MD, PGY1 Psychiatry Resident, starting 2016

 

Collaborators

Helene D. BenvenisteMD, PhD, Professor of Anesthesiology, Yale University.

Linda Chang, MD, Professor of Diagnostic Radiology and Nuclear Medicine, University of Maryland

Thomas Ernst, PhD, Professor of Medicine, Professor of Diagnostic Radiology and Nuclear Medicine, University of Maryland

Anders Fink-Jensen, MD, Professor of Biological Psychiatry, Copenhagen University

Joanna S. Fowler, PhD, Emeritus Chemist, Brookhaven National Laboratory

Samantha Iren​e Scott, PhD, Research Scientist, Vasoptic Medical Inc. 

 

Alumni

Stephen Lee, MS
Graduate student, 2014-2015
Compliance officer, US consumer product safety commission
 
Emily Skarda, BS
Post-Baccalaureate IRTA Fellow, 2014-2015
Medical student, School of Medicine, University of Chicago
 
Samantha Irene Scott, PhD
Post-Doctoral IRTA Fellow, 2014-2015
Research Scientist, Vasoptic Medical Inc.
 
Elizabeth Cabrera, BS
Post-Baccalaureate IRTA Fellow, 2014-2016
Medical student, School of Medicine, University of Pittsburgh
 
Kristina Murani, BA
NIH Graduate Summer Opportunity to Advance Research, 2016
PhD Candidate, American University
 
Elsa Lindgren, BS
Post-Baccalaureate IRTA Fellow, 2015-2017
Medical student, Geisel School of Medicine, Dartmouth College
 
Gregg Miller, BA
Post-Baccalaureate IRTA Fellow, 2015-2017
Medical student, School of Medicine, Tufts University

In Memory
Elena Shumay, MD, PhD

Elene Shumay

Elena was a staff geneticist at LNI. Her interests were in identifying genetic and epigenetic variations that could explain individual differences in brain imaging phenotype. Along with analysis of the accepted genetic markers, she is interested in discovering new polymorphisms in the known candidate genes, exploring previously unspecified genetic targets and assessing them as putative biomarkers.

Read more>>>

 

 

 

Selected Publications

  • Manza P, Tomasi D, Volkow ND. Subcortical local functional hyperconnectivity in cannabis dependence. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (in press) 
  • Wang GJ, Zhao J, Tomasi D, Shokri-Kojori E, Wang R, Wiers CE, Caparelli E, Volkow ND. (in press). Effect of combined naltrexone and bupropion therapy on the brain’s functional connectivity. In Journal of Obesity (in press) 
  • Zhao J, Tomasi D, Wiers CE, Shokri-Kojori E, Demiral SB, Zhang Y, Volkow ND, Wang GJ. Correlation between traits of emotion-based impulsivity and intrinsic default-mode network activity. Neural Plasticity. (in press) 
  • Lindgren E, Gray K, Miller G, Tyler R, Wiers CE, Volkow ND, Wang GJ. Food Addiction: A common neurobiological mechanism with drug abuse. Frontiers in Bioscience. 2018 Jan 1;23:811-836Pubmed
  • Wiers CE, Towb PC, Hodgkinson CA, Shen PH, Freeman C, Miller G, Lindgren E, Shokri-Kojori E, Demiral ŞB, Kim SW, Tomasi D, Sun H, Wang GJ, Goldman D, Volkow ND (2017). Association of genetic ancestry with striatal dopamine D2/D3 receptor availability. Molecular Psychiatry 2017 Nov 7. Epub Pubmed
  • Wiers CE, Cabrera E, Tomasi D, Demiral ŞB, Kim SW, Wong CT, Wang GJ, Volkow ND. (2017). Methylphenidate-induced dopamine release varies across smoking status. Neuropsychopharmacology. 2017 Nov;42(12):2325-2332. Pubmed
  • Tomasi DG, Shokri-Kojori E, Volkow ND. Temporal Evolution of Brain Functional Connectivity Metrics: Could 7 Min of Rest be Enough? Cereb Cortex. 2017 Aug 1;27(8):4153-4165. PubMed
  • Shokri-Kojori E, Tomasi D, Wiers CE, Wang GJ, Volkow ND. (2017). Linking brain connectivity and behavior after acute and chronic alcohol exposure. Mol Psychiatry, 22(8):1079. Pubmed
  • Shokri-Kojori E, Tomasi D, Wiers CE, Wang GJ, Volkow ND (2017). Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers. 2017 Aug;22(8):1185-1195. Pubmed
  • Volkow ND, Wiers CE, Shokri-Kojori E, Tomasi D, Wang GJ, Baler R (2017). Neurochemical and metabolic effects of acute and chronic alcohol in the human brain: studies with positron emission tomography. 2017 Aug 1;122:175-188. Pubmed
  • Shumay E, Wiers CE, Shokri-Kojori E, Kim SW, Hodgkinson CA, Sun H, Tomasi D, Wong CT, Weinberger DR, Wang, GJ, Fowler JS, Volkow ND (2017). New repeat polymorphism in the AKT1 gene predicts striatal dopamine D2/D3 receptor availability and stimulant-induced dopamine release in the healthy human brain. Journal of Neuroscience, 2017 May 10;37(19):4982-4991. Pubmed
  • Tomasi DG, Shokri-Kojori E, Volkow ND. Brain Network Dynamics Adhere to a Power Law. Front Neurosci. 2017 Feb 14;11:72. Pubmed
  • Cunningham SI, Tomasi D, Volkow ND. Structural and functional connectivity of the precuneus and thalamus to the default mode network. Hum Brain Mapp. 2017 Feb;38(2):938-956. Pubmed
  • Tomasi D, Shokri-Kojori E, Wiers CE, Kim SW, Demiral ŞB., Cabrera EA, Lindgren E, Miller G, Wang GJ, Volkow ND (2017). Dynamic brain glucose metabolism identifies anti-correlated networks at rest. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17708692. Pubmed  
  • Wiers CE, Shokri-Kojori E, Wong CT, Abi-Dargham A, Demiral ŞB, Tomasi D, Wang GJ, Volkow ND. Cannabis Abusers Show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males. Neuropsychopharmacology. 2016;41(10):2596-605. PubMed
  • Cabrera EA, Wiers CE, Lindgren E, Miller G, Volkow ND, Wang GJ. Neuroimaging the Effectiveness of Substance Use Disorder Treatments. J Neuroimmune Pharmacol. 2016;11(3):408-33. PubMed
  • Roux A, Jackson SN, Muller L, Barbacci D, O'Rourke J, Thanos PK, Volkow ND, Balaban C, Schultz JA, Woods AS. Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry. ACS Chem Neurosci. 2016 Aug 17;7(8):1148-56. PubMed
  • Zhang Y, Ji G, Xu M, Cai W, Zhu Q, Qian L, Zhang YE, Yuan K, Liu J, Li Q, Cui G, Wang H, Zhao Q, Wu K, Fan D, Gold MS, Tian J, Tomasi D, Liu Y, Nie Y, Wang GJ. (2016) Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery. Int J Obes (Lond). 2016 Jun 21. PubMed
  • Zhang Y, Li Q, Wen X, Cai W, Li G, Tian J, Zhang YE, Liu J, Yuan K, Zhao J, Wang W, Zhou Z, Ding M, Gold MS, Liu Y, Wang GJ. (2016) Granger causality reveals a dominant role of memory circuit in chronic opioid dependence. Addict Biol. 2016 Mar 14. PubMed
  • Thanos PK, Kim R, Delis F, Ananth M, Chachati G, Rocco MJ, Masad I, Muniz JA, Grant SC, Gold MS, Cadet JL, Volkow ND. Chronic Methamphetamine Effects on Brain Structure and Function in Rats. PLoS One. 2016 Jun 8;11(6):e0155457. PubMed
  • Tomasi D, Wang GJ, Volkow ND. Association between striatal dopamine D2/D3 receptors and brain activation during visual attention: effects of sleep deprivation. Transl Psychiatry. 2016 May 31;6(5):e828. PubMed
  • Tomasi D, Shokri-Kojori E, Volkow ND. Temporal Changes in Local Functional Connectivity Density Reflect the Temporal Variability of the Amplitude of Low Frequency Fluctuations in Gray Matter. PLoS One. 2016 Apr 26;11(4):e0154407 PubMed
  • Thanos PK, Malave L, Delis F, Mangine P, Kane K, Grunseich A, Vitale M, Greengard P, Volkow ND. (2016) Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned. Synapse. 2016;70(7):293-301. PubMed
  • Belcher AM, Yen CC, Notardonato L, Ross TJ, Volkow ND, Yang Y, Stein EA, Silva AC, Tomasi D. Functional Connectivity Hubs and Networks in the Awake Marmoset Brain. Front Integr Neurosci. 2016;10:9. PubMed
  • Wiers CE, Shumay E, Cabrera E, Shokri-Kojori E, Gladwin TE, Skarda E, Cunningham SI, Kim SW, Wong TC, Tomasi D, Wang GJ, Volkow ND. Reduced sleep duration mediates decreases in striatal D2/D3 receptor availability in cocaine abusers. Transl Psychiatry. 2016 Mar 8;6:e752. PubMed
  • Wiers CE, Shokri-Kojori E, Cabrera E, Cunningham S, Wong C, Tomasi D, Wang GJ, Volkow ND. Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers. Neurosci Lett. 2016 Mar 23;617:27-31. PubMed
  • Zhang Q, You J, Volkow ND, Choi J, Yin W, Wang W, Pan Y, Du C. Chronic cocaine disrupts neurovascular networks and cerebral function: optical imaging studies in rodents. J Biomed Opt. 2016 Feb;21(2):26006.  PubMed
  • Wiers CE, Cabrera E, Skarda E, Volkow ND, Wang GJ. PET imaging for addiction medicine: From neural mechanisms to clinical considerations. Prog Brain Res. 2016;224:175-201. PubMed
  • Tomasi D, Shokri-Kojori E, Volkow ND. High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability. Cereb Cortex. 2016;26(7):3249-59. PubMed
  • Volkow N.D., Wang G.J., Smith L., Fowler J.S., Telang F., Logan J., Tomasi D. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. Neuroimage. 2015;121:20-8. PubMed
  • Tomasi D., Wang G.J., Studentsova Y., Volkow N.D. Dissecting Neural Responses to Temporal Prediction, Attention, and Memory: Effects of Reward Learning and Interoception on Time Perception. Cereb Cortex. 2015;25(10):3856-67. PubMed
  • Wiers C.E., Shumay E., Volkow N.D., Frieling H., Kotsiari A., Lindenmeyer J., Walter H., Bermpohl F. Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism. Transl Psychiatry. 2015;5:e648. PubMed
  • Tomasi D., Wang G.J., Volkow N.D. Balanced modulation of striatal activation from D2 /D3 receptors in caudate and ventral striatum: Disruption in cannabis abusers. Hum Brain Mapp. 2015;36(8):3154-66. PubMed
  • Tomasi D., Shokri-Kojori E., Volkow N.D. High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability. Cereb Cortex. 2016; 26(7):3249-59. PubMed
  • Volkow N.D., Baler R.D. NOW vs LATER brain circuits: implications for obesity and addiction. Trends Neurosci. 2015 Jun;38(6):345-52. PubMed
  • Ferré S., Bonaventura J., Tomasi D., Navarro G., Moreno E., Cortés A., Lluís C., Casadó V., Volkow N.D. Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer. Neuropharmacology. 2015;104:154-60. PubMed
  • Volkow N.D., Koob G., Baler R. Biomarkers in substance use disorders. ACS Chem Neurosci. 2015 Apr 15;6(4):522-5. PubMed
  • Kravitz A.V., Tomasi D., LeBlanc K.H., Baler R., Volkow N.D., Bonci A., Ferré S. Cortico-striatal circuits: Novel therapeutic targets for substance use disorders. Brain Res. 2015; 1628(Pt A):186-98. PubMed
  • Volkow N.D., Wang G.J., Logan J., Alexoff D., Fowler J.S., Thanos P.K., Wong C., Casado V., Ferre S., Tomasi D. Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Transl Psychiatry. 2015 Apr 14;5:e549. PubMed
  • Fowler J.S., Logan J., Shumay E., Alia-Klein N., Wang G.J., Volkow N.D. Monoamine oxidase: radiotracer chemistry and human studies. J Labelled Comp Radiopharm. 2015 Mar;58(3):51-64. PubMed
  • Volkow N.D., Baler R. Beliefs modulate the effects of drugs on the human brain.  Beliefs modulate the effects of drugs on the human brain.  Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2301-2. PubMed
  • Biegon A., Alexoff D., Kim S.W., Logan J, Pareto D, Schlyer D, Wang GJ, Fowler J. Aromatase Imaging with [N-methyl-C-11]vorozole PET in Healthy Men and Women. J Nucl Med. 2015; 56(4):580-5. PubMed
  • Volkow N.D., Wang G.J., Shokri Kojori E., Fowler J.S., Benveniste H., Tomasi D. Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases. J Neurosci. 2015 Feb 18;35(7):3248-55. PubMed
  • Fowler JS, Logan J, Shumay E, Alia-Klein N, Wang GJ, Volkow ND. Monoamine oxidase: radiotracer chemistry and human studies. J Labelled Comp Radiopharm. 2015; 58(3):51-64. PubMed
  • Fowler JS, Logan J, Volkow ND, Shumay E, McCall-Perez F, Jayne M, Wang GJ, Alexoff DL, Apelskog-Torres K, Hubbard B, Carter P, King P, Fahn S, Gilmor M, Telang F, Shea C, Xu Y, Muench L. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain. Neuropsychopharmacology. 2015 Feb;40(3):650-7. PubMed
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  • Tomasi D., Wang G.J., Studentsova Y., Volkow N.D. Dissecting Neural Responses to Temporal Prediction, Attention, and Memory: Effects of Reward Learning and Interoception on Time Perception. Cereb Cortex. 2014 Nov 11. pii: bhu269. [Epub ahead of print] PubMed
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  • Volkow N.D., Tomasi D., Wang G.J., Logan J., Alexoff D.L., Jayne M., Fowler J.S., Wong C., Yin P., Du C. Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. Mol Psychiatry. 2014 Sep;19(9):1037-43. PubMed
  • Kim S.W., Fowler J.S., Skolnick P., Muench L., Kang Y., Shea C., Logan J., Kim D., Carter P., King P., Alexoff D., Volkow N.D. Therapeutic doses of buspirone block D3 receptors in the living primate brain. Int J Neuropsychopharmacol. 2014 Aug;17(8):1257-67. PubMed
  • Volkow N.D., Wang G.J., Telang F., Fowler J.S., Alexoff D., Logan J., Jayne M., Wong C., Tomasi D. Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3149-56. PubMed
  • Seo Y.J., Kang Y., Muench L., Reid A., Caesar S., Jean L., Wagner F., Holson E., Haggarty S.J., Weiss P., King P., Carter P., Volkow N.D., Fowler J.S., Hooker J.M., Kim S.W. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. ACS Chem Neurosci. 2014 Jul 16;5(7):588-96. PubMed
  • Logan J., Kim S.W., Pareto D., Telang F., Wang G.J., Fowler J.S., Biegon A. Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography. Mol Imaging. 2014 May;13(3):1-12. PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Studentsova Y., Margus B., Crawford T.O. Brain glucose metabolism in adults with ataxia-telangiectasia and their asymptomatic relatives. Brain. 2014 Jun;137(Pt 6):1753-61. PubMed
  • Wang G.J., Tomasi D., Volkow N.D., Wang R., Telang F., Caparelli E.C., Dunayevich E. Effect of combined naltrexone and bupropion therapy on the brain's reactivity to food cues. Int J Obes (Lond). 2014 May;38(5):682-8. PubMed
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  • Tomasi D., Volkow N.D. Functional connectivity of substantia nigra and ventral tegmental area: maturation during adolescence and effects of ADHD. Cereb Cortex. 2014 Apr;24(4):935-44. PubMed
  • Moeller S.J., Honorio J., Tomasi D., Parvaz M.A., Woicik P.A., Volkow N.D., Goldstein R.Z. Methylphenidate enhances executive function and optimizes prefrontal function in both health and cocaine addiction. Cereb Cortex. 2014 Mar;24(3):643-53. PubMed
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  • Wang G.J., Tomasi D., Convit A., Logan J., Wong C.T., Shumay E., Fowler J.S., Volkow N.D. BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake. PLoS One. 2014 Jul 7;9(7):e101585. PubMed
  • Tomasi D., Volkow N.D. Mapping small-world properties through development in the human brain: disruption in schizophrenia. PLoS One. 2014 Apr 30;9(4):e96176. PubMed
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  • Michaelides M., Anderson S.A., Ananth M., Smirnov D., Thanos P.K., Neumaier J.F., Wang G.J., Volkow N.D., Hurd Y.L. Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks. J Clin Invest. 2013 Dec;123(12):5342-50. PubMed
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  • Volkow N.D., Swanson J.M. Clinical practice: Adult attention deficit-hyperactivity disorder. N Engl J Med. 2013 Nov 14;369(20):1935-44. Review. PubMed
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  • Tomasi D., Volkow N.D. Brain activation and neurochemistry. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10888-9. PubMed
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  • Volkow N.D, Tomasi D., Wang G.J., Telang F., Fowler J.S., Goldstein R.Z., Klein N., Wong C., Swanson J.M., Shumay E. Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism. PLoS One. 2013 May 22;8(5):e63492. PubMed
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  • Volkow N.D., Wang G.J., Tomasi D., Baler R.D. The addictive dimensionality of obesity. Biol Psychiatry. 2013 May 1;73(9):811-8. Review. PubMed
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  • Tomasi D., Volkow N.D. Striatocortical pathway dysfunction in addiction and obesity: differences and similarities. Crit Rev Biochem Mol Biol. 2013 Jan-Feb;48(1):1-19. Review. PubMed
  • Volkow N.D., Kim S.W., Wang G.J., Alexoff D., Logan J., Muench L., Shea C., Telang F., Fowler J.S., Wong C., Benveniste H., Tomasi D. Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain. Neuroimage. 2013 Jan 1;64:277-83. PubMed
  • Volkow N.D., Wang G.J., Tomasi D., Baler R.D. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013 Jan;14(1):2-18. Review. PubMed
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  • Volkow N.D. Long-term safety of stimulant use for ADHD: findings from nonhuman primates. Neuropsychopharmacology. 2012 Nov;37(12):2551-2. PubMed
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  • Tomasi D., Volkow N.D. Language network: segregation, laterality and connectivity. Mol Psychiatry. 2012 Jul;17(8):759.
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  • Tomasi D., Volkow N.D. Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2012 Mar 1;71(5):443-50. PubMed
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Last reviewed: November 2017