Laboratory of Neuroimaging

Laboratory of Neuroimaging (LNI)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institutes of Health
10 Center Drive, Room B2L124: MSC 1013
Bethesda, MD 20892-1013

 

Chief of Laboratory
Nora D. Volkow, MD
Senior Investigator, NIAAA
Director, National Institute on Drug Abuse (NIDA)
Phone: 1 (301) 402-0868
E-mail: nvolkow@nida.nih.gov

Dr. Volkow became Director of the National Institute on Drug Abuse (NIDA) at the National Institutes of Health in May 2003. In addition to her role in NIDA, she is the chief of LNI in NIAAA. Her work has been instrumental in demonstrating that drug addiction is a disease of the human brain. As a research psychiatrist and scientist, Dr. Volkow pioneered the use of brain imaging to investigate the toxic effects and addictive properties of abusable drugs. Her studies have documented changes in the dopamine system affecting, among others, the functions of frontal brain regions involved with motivation, drive, and pleasure in addiction. She has also made important contributions to the neurobiology of obesity, ADHD, and aging. Dr. Volkow has published more than 580 peer-reviewed articles and written more than 90 book chapters and non-peer reviewed manuscripts, and has also edited three books on neuroimaging for mental and addictive disorders.

 

What we do

LNI uses brain imaging (PET, MRI and simultaneous PET/MRI) to study the neurocircuitry that underlies the rewarding effects of drugs of abuse and of natural reinforcers and their disruption in diseases of addiction and obesity. For this purpose we study how reward circuits modulate executive function (self-control), interoception, and motivation in the normal human brain including an understanding of the role of brain dopamine signaling, functional brain network interactions and genetics. We evaluate the disruption of these interactions in substance use disorder and morbid obesity, which are disorders characterized by deficits in self-control and reward sensitivity. We also focus on methodological studies to advance the tools to study function of the human brain including development of PET radiotracers, which is focused on the development of ligands to map epigenetic processes, development of analytical tools to help analyze and understand the underlying physiology behind the dynamically complex patterns of brain networks.

 

We are looking for volunteers!

 

Our Research Protocols that are actively recruiting volunteers:

14-AA-0144 Reliability of The Human Brain Connectome

15-AA-0186 Development of Neuroimaging Methods to Assess the Neurobiology of Addiction

17-AA-0114 Brain Dopaminergic Signaling in Opioid Use Disorders (OUD)

17-AA-0152 Ketogenic Diet (KD) in Alcoholism

17-AA-0178 Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

 

Research Protocols that are not recruiting:

14-AA-0187 Dopamine Rhythms in Health and Addiction

15-AA-0031 Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness 

16-AA-0059 Characterization of Brain Amyloid-beta (A-beta) Retention During Wakefulness And Following Emergence From Sleep In Healthy Subjects 

14-AA-0192 Brain Inflammation and Function in Alcoholism

 

Current Staff

Sung Won (Sunny) Kim, Ph.D.
Staff Scientist
Phone: 1 (301) 496-5548
E-mail: kims8@mail.nih.gov

Sunny is an organic chemist as well as chief radiochemist of LNI. His research focus has been on radiotracer development and its medical application using positron emission tomography (PET). His research involves the following: 1) design or selection of suitable molecules for radiotracer guided by in vitro biological activity, 2) organic synthesis and radiochemistry for in vivo imaging, and 3) optimization of radiotracers using rodents and non-human primates for translational research to humans. Recently, he completed the in vivo pharmacological profiling of buspirone using multiple dopamine tracers, to evaluate its potential for the treatment of cocaine addiction using a D3R-prefering radiotracer called[11C]PHNO. Since 2009, he continues his effort for in vivo imaging tool development targeting brain epigenetic biomarkers such as histone deacetylase (HDAC). Currently, he is also interested in automation and miniaturization of radiosynthesis devices for carbon-11 precursors and compounds, to optimize radiotracer production and streamline laboratory operations.

 

Dardo Tomasi, Ph.D.
Staff Scientist
Phone: 1 (301) 496-1589
E-mail: dardo.tomasi@nih.gov

Dardo is an MRI physicist with expertise in gradient coil design, functional MRI and PET imaging. His work focuses on brain metabolism, function, structure and neurochemistry in normal subjects and psychiatric populations. He is interested on novel MRI approaches to map brain function and connectivity with high temporal and spatial resolution. Recently, Dr. Tomasi developed ultra-fast graph theory methods to compute short- and long-range functional connectivity maps from "resting-state" echo-planar imaging time series that when used in large public image databases revealed pronounced gender and aging effects on the brain's functional architecture.

 

Gene-Jack Wang, MD
Senior Clinician & Clinical Director
Phone: 1 (301) 496-5012
E-mail: gene-jack.wang@nih.gov

Gene-Jack is a board certified Nuclear Medicine physician. He joined NIAAA as a senior clinician and the clinical director of LNI in 2013. Prior to his current appointment, he was a professor of Radiology at Stony Brook University, a senior scientist and chairman of the medical department at Brookhaven National Laboratory. He also held a joint appointment as a professor of Psychiatry at Mount Sinai School of Medicine. His research focuses on the application of PET and functional MRI to the study of various brain disorders. He is interested in using PET to study the neuro-psychiatric mechanisms and manifestations of alcoholism, drug addiction, ADHD, obesity and eating disorder in humans. Using PET, he first reported similarity of human brain circuits’ disruption in drug addiction and in obesity. Prior to his appointment in NIH, he had obtained grant awards from Department of Energy, NIH and pharmaceutical company to support his research. As results of his imaging research, he has published 281 original articles, 45 review articles, 18 book chapters.

 

Karen Torres
Protocol Coordinator
Phone: 1 (301) 496-4186
E-mail: karen.torres@nih.gov

Karen joined the Laboratory of Neuroimaging (LNI) as a Clinical Protocol Coordinator in 2010. Previous to coming on board in the NIAAA/LNI, she performed the same role starting in 2003 when the NIAAA/LNI was first established at the Brookhaven National Laboratory (BNL) in Upton, NY. Karen's role as the Clinical Protocol Coordinator covers working on and managing protocols starting from inception through, scientific review, IRB submissions, IND preparation and protocol implementation. She organizes and schedules scientific seminars, presentations and talks by current lab staff as well as invited guests. In addition to these activities, she manages the NIAAA calendar for the Laboratory Chief of LNI.

 

Minoo McFarland, MSN, CFNP
Nurse Practitioner
Phone: (301) 496-4186
E-mail: minoo.mcfarland@nih.gov

Minoo is a board-certified Family Nurse Practitioner. She obtained her Master of Science in Nursing in 2001 from George Mason University in collaboration with the George Washington University School of Medicine. Prior to joining NIAAA she worked at Allergy Partners as a nurse practitioner caring for patients with diseases of allergy and asthma. In the past, Ms. McFarland worked at Inova Transplant Center as a transplant coordinator caring for kidney and pancreas transplant patients. Prior to that she worked at an internal medicine office. She joined LNI in January of 2017. She screens and evaluates participants and assigns them to different protocols. She educates the participants with the procedures and provides patient care during procedures and follow-ups. She is responsible for coordination and implementation of clinical research projects. She aids in data collection and documentation for the study.

 

Michele-Vera Yonga, CRNP, FNP
Nurse Practitioner
Phone: (301) 402-0910
Email: michele-vera.yonga@nih.gov 

Michele-Vera Yonga is a Board-Certified Family Nurse Practitioner. She joined the Laboratory of Neuroimaging at the National Institute of Alcohol Abuse and Alcoholism in May 2019. Prior to joining NIAAA, she worked as a Nurse Practitioner in Family Practice/Urgent Care, seeing patients with a diverse array of medical conditions. Prior to working in urgent care, she worked as a Registered Nurse in Acute Care Rehabilitation at the Medstar National Rehabilitation Hospital in Washington D.C. for several years. Mrs. Yonga also worked as Nursing Supervisor in skilled nursing for a couple of years prior to working at Medstar. At LNI, she screens and evaluates participants and assigns them to different protocols. She educates the participants with the procedures and provides patient care during procedures and follow-ups. She is responsible for coordination and implementation of clinical research projects. She assists with data collection and documentation.

 

Frank Sutak, BS, MA, ARRT
MRI Technologist
Phone: (301) 451-1504
Email: frank.sutak@nih.gov

Frank Sutak is MRI ARRT certified with ten years of experience working at Walter Reed National Medical Center and Mary Washington Hospital.  He is a recipient of multiple awards for patient care excellence including the Sherman Award.  He has operated 1.5 & 3.0 GE, 3.0 Siemens, 1.5 Philips open and closed scanners.  BLS and ACLS certified. He holds a B.S. in Radiologic Science and a M.A. in International Studies.  

 

Christopher T. Wong, BS, CNMT
Data Manager
Phone: 1 (301) 496-4186
E-mail: chris.wong@nih.gov

 

Ehsan Shokri Kojori, Ph.D.
Research Fellow
Phone: 1 (301) 451-3020
E-mail: ehsan.shokrikojori@nih.gov

Ehsan joined the lab as a postdoctoral IRTA fellow in August 2014 and became a Research Fellow in May 2016. He earned a Ph.D. degree in cognitive neuroscience from the University of Texas at Dallas in Spring 2014. Ehsan also has a background in electrical engineering and signal processing. His interests include combining brain imaging modalities (e.g., fMRI, DTI, and PET) and behavioral measurements to understand the neurocognitive underpinnings of goal directed behavior. His current work involves studying how addiction and alcohol abuse affect efficiency and energetic cost of the brain networks. He is also working on developing novel methodologies to better characterize anatomical and functional brain connectivity indices.

 

Corinde Wiers, Ph.D.
Research Fellow
Phone: 301-451-3021
E-mail: corinde.wiers@nih.gov

Corinde joined the LNI as a Postdoctoral IRTA Fellow in September 2014, and became a Research Fellow in September 2016. She studied psychology and psychobiology at the University of Amsterdam (Netherlands) and Sussex University (UK), and earned her Ph.D. in psychology from the Berlin School of Mind and Brain and Free University Berlin (Germany). Her research investigates cognitive and neurobiological processes involved in addiction, using fMRI, PET and psychophysics. She currently works on testing the effects of a ketogenic diet intervention on withdrawal symptoms and brain functioning in alcohol use disorder.

 

Peter Manza, Ph.D.
Postdoctoral IRTA Fellow
Phone: 301-496-5012
E-mail: peter.manza@nih.gov

Pete joined the LNI as a postdoctoral IRTA fellow in February 2017. He studied psychology and biology at the University of Rochester and earned his Ph.D. in integrative neuroscience from Stony Brook University in December 2016. Pete is interested in how dopamine influences cognitive control in health and neuropsychiatric disease. He is currently working on combining fMRI, PET, and neuropsych measures to understand how negative emotionality and stress influence brain functions that support cognitive control in drug addiction.

 

Gus Bakhoda, PhD
Postdoctoral IRTA Fellow
E-mail: gus.bakhoda@nih.gov

Gus joined the LNI as an IRTA postdoctoral fellow in June 2019. He is an organometallic chemist who completed his B.S in University of Tehran and received his Ph.D. from Georgetown University. His Ph.D. research focused on base-metal catalyzed C-H functionalization. His research at the LNI involves the design and synthesis of radiotracers as diagnostic tools for in vitro and in vivo bioimaging.

 

Joseph Ramsey, BS
E-Mail: joseph.ramsey@nih.gov

Joseph received his B.S. in Neuroscience and B.A in Spanish from Tulane University in May of 2018 and began working in the LNI shortly after in June. He is interested in exploring in vivo models of neurodevelopment and neurocircuitry on cellular and molecular levels, particularly as they relate to cases of atypical cellular development. In the future he hopes to utilize both of his undergraduate areas of interest in the context of urban medicine.

 

Danielle Kroll, BA
Post-Baccalaureate IRTA Fellow
Phone: 301-827-7076
E-Mail: danielle.kroll@nih.gov

Danielle received her B.A. in Linguistics and Biology from Dartmouth College in June 2018 and joined the Laboratory of Neuroimaging the following July. Danielle plans to attend medical school in the future.

 

Dana Feldman, BS
Post-Baccalaureate IRTA Fellow
E-Mail: dana.feldman@nih.gov

Dana received her B.S. in Biopsychology, Cognition, and Neuroscience from the University of Michigan in April 2018 and joined the Laboratory of Neuroimaging in August 2018 as postbac research assistant. Dana aspires to attend medical school in the future.

 

Katherine McPherson, BS
Post-Baccalaureate IRTA Fellow
E-Mail: katherine.mcpherson@nih.gov
Phone: (301) 451-2116

Katherine received her B.S. in Biological Sciences from Cornell University in December 2018 and joined the Laboratory of Neuroimaging the following June. Katherine plans to attend medical school in the future.

 

Catherine Biesecker, BA
Post-Baccalaureate IRTA Fellow
E-Mail: catherine.biesecker@nih.gov
Phone: (301) 451-1505

Catherine (Erin) Biesecker received a degree in Psychology from The College of William & Mary in the Spring of 2019. After participating in clinical experiences such as the William & Mary Dean’s Emotion Behavior Lab and a study abroad experience working in a child development lab at the University of Sydney in Australia, she excitedly started her work as an IRTA at LNI in NIAAA. 

 

Andrew Kelleher, BSE
Post-Baccalaureate IRTA Fellow
E-Mail: andrew.kelleher@nih.gov

Andy received his B.S.E. in Biomedical Engineering from Duke University in May 2019 and began working in the LNI shortly after in June. He is interested in exploring the intersections between bioengineering and medicine, particularly how to model whole body, tissue, and cellular systems to solve problems of drug delivery and bioinformatics. He hopes to attend medical school in the future. 

 

Special Volunteers

 

Sukru Baris Demiral, Ph.D.
E-mail: sukru.demiral@nih.gov

Baris received his PhD from the University of Leipzig, Faculty of Biosciences, Pharmacy and Psychology, Germany, through a joint project in Max Planck Institute Cognitive and Brain Sciences. He studied physics in his undergraduate studies, then conducted cognitive modeling work and neurolinguistics research in the following years. His developing interests in neurophysiology, neurotransmitter dynamics, addiction, motivation, and genetics led him to work in a number of neurophysiology labs as a post-doc. He joined LNI in early 2016, and he explored the effects of arousal, sleep, and sleep deprivation on neural dynamics, brain metabolism, and health via multi-modal imaging including fMRI, PET and simultaneous EEG-fMRI techniques.  Currently, he is a research scientist of Walter Reed research center and joins the lab as a special volunteer since May 2018.

 

Wenjing Zhao, Ph.D.
E-mail: wenjing.zhao@nih.gov

Wenjing got her Ph.D degree in Organic Chemistry in Shandong University, China. She joined the Laboratory of Neuroimaging in March 2018. Recently, she is studying radiolabeling and the internship μ-opioid receptor with different ligands.

 

Rui Zhang, PhD
E-mail: rui.zhang@nih.gov

Rui studied psychology at the University of Marburg and received her Ph.D. in cognitive neuroscience from the Technical University of Dresden in Germany. After Ph.D., Rui joined LNI as a special volunteer with research fellowship from German Research Foundation in November 2018. Her previous research examined cognitive control and related neurophysiological mechanisms and neurotransmissions in healthy adults and patients with neurological disorders, using EEG and MRS. Currently, she is interested in how sleep modulates brain activity and connectivity in drug-addicted individuals and how this correlates to compromised cognition and risky behavior observed in is group.

 

Szu-Yung (Ariel) Wang, MD
E-mail: ariel.wang@nih.gov

Ariel joined LNI as a special volunteer in November 2018. She obtained her Bachelor of Art degree in Psychology and Molecular Cell Biology from University of California, Berkeley in 2010 where she had research experiences working with autoradiography, immunocytochemistry, genetic sequencing and animal behavior studies of GnIH in songbirds and macaque monkey brains. She received her Doctoral Degree in Medicine from the Kaohsiung Medical University in Kaohsiung, Taiwan in 2018 with a year of medical intern training in Kaohsiung Medical University Hospital.  She is currently working on analyzing the ABCD study data to understand the neurobiological impact of drugs and substance use on cognitive development in children by investigating in these brain-behavior relationships in structural and functional neuroimaging, including task fMRI, resting fMRI, and diffusion MRI. She is interested in children’s neurocognitive developments and plan to pursue residency related to pediatric neurology or psychiatry.

 

Yeona Kang, Ph.D. 
E-mail: yeona.kang@nih.gov

Yeona is an assistant professor of mathematics at Howard University, DC, Washington. She joined the lab as a special volunteer in December 2018.  She received her PhD from the State University of New York at stony brook, applied mathematics and statistics, in mathematical modeling of the protein folding structure prediction.  Her current research interests focus on understanding the blood brain barrier penetration/disruption with PET/MRI brain kinetic modeling in drug addiction.
 

Chung-An (Tommy) Fang, MD, MS
E-mail: chung-an.fang@nih.gov

Tommy joined the LNI as a special volunteer in August 2019. He received B.S. in Biological Sciences and Interdisciplinary Program Certificate in Biotechnology from the National Sun Yat-sen University, Taiwan and M.S. in Microbiology & Immunology from the National Taiwan University, College of Medicine, where he studied tumorigenesis induced by Epstein-Barr virus latent infection. He did neurosurgery clerkship rotation in the Massachusetts General Hospital in March 2019 and obtained M.D. degree from the Kaohsiung Medical University, Taiwan in June 2019. His previous research included morphology analysis on neurons under ACE inhibitor treatment and exploration of molecular mechanism underlying observed cell fate reversing and neurite regrowth effects. Currently, he is working on novel radiotracer development for opioid use disorder. His works focus on using MicroPET imaging technique to assess feasibility of newly developed PET tracers for opioid receptors imaging on murine models. Tommy is interested in restoration of dysfunctional neural circuits. He plans to pursue residency training in neurology or neurosurgery.

 

Walter Reed Psychiatry Resident Research Rotation

Kyle Gray, MD, PGY3 Psychiatry Resident, starting 2015

Shram Shukla, MD, PGY2 Psychiatry Resident, starting 2016

 

Collaborators 

Helene D. Benveniste, MD, PhD, Professor of Anesthesiology, Yale University.

Linda Chang, MD, Professor of Diagnostic Radiology and Nuclear Medicine, University of Maryland

Thomas Ernst, PhD, Professor of Medicine, Professor of Diagnostic Radiology and Nuclear Medicine, University of Maryland

Anders Fink-Jensen, MD, Professor of Biological Psychiatry, Copenhagen University, Denmark

Julia Cole Finkel, MD, Professor of Anesthesiology, Pediatrics and Critical Care Medicine
Children's National Medical Center and George Washington University

Joanna S. Fowler, PhD, Emeritus Chemist, Brookhaven National Laboratory, New York

Samantha Irene Scott, PhD, Founder and CEO, JuneBrain, LLC, Maryland.

Yi Zhang, PhD, Professor, School of Life Science and Technology, Xidian University, China

Kai Yuan, PhD, Professor, School of Life Science and Technology, Xidian University, China

Paule V. Joseph, PhD, Chief, Sensory Science and Metabolism Unit, National Institute of Nursing Research.

Alumni

In Memory
Elena Shumay, MD, PhD

Elena was a staff geneticist at LNI. Her interests were in identifying genetic and epigenetic variations that could explain individual differences in brain imaging phenotype. Along with analysis of the accepted genetic markers, she is interested in discovering new polymorphisms in the known candidate genes, exploring previously unspecified genetic targets and assessing them as putative biomarkers.

Read more >>>

 

 

Selected Publications

• Burns JA, Kroll DS, Feldman DE, Kure Liu C, Manza P, Wiers CE, Volkow ND, Wang GJ. Molecular imaging of opioid and dopamine systems: insights into the pharmacogenetics of opioid use disorders. Front. Psychiatry. (In Press)
• Wiers CE, Martins de Carvalho L, Hodgkinson CA, Schwandt M, Kim SW, Diazgranados N, Wang GJ, Goldman D, Volkow ND. TSPO polymorphism in individuals with alcohol use disorder: Association with cholesterol levels and withdrawal severity. Addiction Biology. (In Press)
• Tomasi DG, Wiers CE, Shokri-Kojori E, Zehra A, Ramirez V, Freeman C, Burns J, Kure Liu C, Manza P, Kim SW, Wang GJ, Volkow ND. Association between reduced brain glucose metabolism and Cortical Thickness in Alcoholics: Evidence of Neurotoxicity. Int J Neuropsychopharacol. (2019) Pubmed
• Zhang R, Volkow ND. Brain default-mode network dysfunction in addiction. Neuroimage (2019). Pubmed
• Manza O, Shokri-Kojori E, Volkow ND. Reduced segregation between cognitive and emotional processes in cannabis dependence. Cereb. Cortex. (2019). Pubmed
• Martins de Carvalho L, Wiers CE, Manza P, Sun H, Schwandt M, Wang GJ, Grassi-Oliveira R, Godard ALB, Volkow ND. Effect of alcohol use disorder on cellular aging. Psychopharmacology (2019). Pubmed
• Kure Liu C, Joseph PV, Feldman DE, Kroll DS, Burns JA, Manza P, Volkow ND, Wang GJ. Brain Imaging of Taste Perception in Obesity: a Review. Current Nutrition Reports (2019). Pubmed
• Tyler RE, Kim SW, Guo M, Jang YJ, Damadzic R, Stodden T, Vendruscolo LF, Koob GF, Wang GJ, Wiers CE, Volkow ND. Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding. Eur J Neurosci. (2019). Pubmed
• Wang GJ, Wiers CE, Shumay E, Tomasi D, Yuan K, Wong CT, Logan J, Fowler JS, Volkow ND. Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder. Translational psychiatry (2019) Pubmed
• Shokri-Kojori E, Tomasi D, Alipanahi B, Wiers CE, Wang GJ, Volkow ND. Correspondence between cerebral glucose metabolism and BOLD reveals relative power and cost in human brain. (2019) Pubmed
• Li G, Ji G, Hu Y, Liu L, Jin Q, Zhang W, Liu L, Wang Y, Zhao J, von Deneen KM, Chen A, Cui G, Han Y, Wang H, Zhao Q, Wu K, Wiers CE, Tomasi D, Leggio L, Volkow ND, Nie Y, Zhang Y, Wang GJ. Reduced plasma ghrelin concentrations are associated with decreased brain reactivity to food cues after laparoscopic sleeve gastrectomy. Psychoneuroendocrinology (2019). Pubmed
• Tomasi D, Volkow ND. Reduced Local and Increased Long-Range Functional Connectivity of the Thalamus in Autism Spectrum Disorder. Cereb Cortex (2019). Pubmed
• Demiral ŞB, Tomasi D, Sarlls J, Lee H, Wiers CE, Zehra A, Srivastava T, Ke K, Shokri-Kojori E, Freeman CR, Lindgren E, Ramirez V, Miller G, Bandettini P, Horovitz S, Wang GJ, Benveniste H, Volkow ND. Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system? Neuroimage (2019). Pubmed
• Zehra A, Lindgren E, Wiers CE, Freeman C, Miller G, Ramirez V, Shokri-Kojori E, Wang GJ, Talagala L, Tomasi D, Volkow ND. Neural correlates of visual attention in alcohol use disorder. Drug Alcohol Depend (2019). Pubmed
• Shokri-Kojori, E, Dardo T, Volkow ND. An Autonomic Network: Synchrony Between Slow Rhythms of Pulse and Brain Resting State Is Associated with Personality and Emotions. Cerebral Cortex (2018). Pubmed
• Li G, Ji G, Hu Y, Xu M, Jin Q, Liu L, von Deneen KM, Zhao J, Chen A, Cui G, Wang H, Zhao Q, Wu K, Shokri-Kojori E, Tomasi D, Volkow ND, Nie Y, Zhang Y, Wang GJ. Bariatric surgery in obese patients reduced resting connectivity of brain regions involved with self-referential processing. Hum Brain Mapp. (2018). Pubmed
• Zehra A, Burns J, Liu CK, Manza P, Wiers CE, Volkow ND, Wang GJ. Cannabis Addiction and the Brain: a Review. J Neuroimmune Pharmacol. (2018). Pubmed
• Wang R, Li M, Zhao M, Yu D, Hu Y, Wiers CE, Wang GJ, Volkow ND, Yuan K. Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway. Brain Imaging Behav. (2018). Pubmed
• Wiers CE, Lohoff FW, Lee J, Muench C, Freeman C, Zehra A, Marenco S, Lipska BK, Auluck PK, Feng N, Sun H, Goldman D, Swanson JM, Wang GJ, Volkow ND. Methylation of the dopamine transporter gene in blood is associated with striatal dopamine transporter availability in ADHD: a preliminary study. Eur J Neurosci. (2018). Pubmed
• Tomasi D, Volkow ND. Association Between Brain Activation and Functional Connectivity. Cereb Cortex. (2018). Pubmed
• Freeman CR, Wiers CE, Sloan ME, Zehra A, Ramirez V, Wang GJ, Volkow ND. Emotion Recognition Biases in Alcohol Use Disorder. Alcohl Clin Exp Res. (2018). Pubmed
• Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, Wang GJ, Volkow ND, Hurd YL. Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity. Mol Psychiatry. (2018). Pubmed
• Gu X, Chen W, Volkow ND, Koretsky AP, Du C, Pan Y. Synchronized Astrocytic Ca²⁺ Responses in Neurovascular Coupling during Somatosensory Stimulation and for the Resting State. Cell Rep. (2018). Pubmed
• Liu, L, Ji, G, Li, G, Hu, Y, Jin, Q, Hu, C, Zhao J, Meng Q, von Deneen KM, Chen A, Cui G, Wang H, Zhao Q, Wu K, Tian J, Shokri-Kojori E, Tomasi D, Volkow ND, Nie Y, Zhang Y, Wang GJ. Structural changes in brain regions involved in executive-control and self-referential processing after sleeve gastrectomy in obese patients. Brain Imaging and Behavior (2018). Pubmed
• Zhang Y, Ji G, Li G, Hu Y, Liu L, Jin Q, Meng Q, Zhao J, Yuan K, Liu J, von Deneen KM, Chen A, Cui G, Wang H, Zhao Q, Wu K, Tian J, Manza P, Tomasi DG, Volkow ND, Nie Y, Wang G-J. Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus. Int J Obese (2018). Pubmed
• Park K, Chen W, Volkow ND, Allen CP, Pan Y, Du C. Hemodynamic and neuronal responses to cocaine differ in awake versus anesthetized animals: Optical brain imaging study. Neuroimage (2018). Pubmed
• Demiral ŞB, Tomasi D, Wiers CE, Manza P, Shokri-Kojori E, Studentsova Y, Wang GJ, Volkow ND. Methylphenidate's effects on thalamic metabolism and functional connectivity in cannabis abusers and healthy controls. Neuropsychopharmacology (2018). Pubmed
• Guo M, Gao ZG, Tyler R, Stodden T, Li Y, Ramsey J, Zhao WJ, Wang GJ, Wiers CE, Fowler JS, Rice KC, Jacobson KA, Kim SW, Volkow ND. Preclinical Evaluation of the First Adenosine A₁ Receptor Partial Agonist Radioligand for Positron Emission Tomography Imaging. J Med Chem. (2018). Pubmed
• Wang GJ, Zhao J, Tomasi D, Shokri-Kojori E, Wang R, Wiers CE, Caparelli E, Volkow ND. Effect of combined naltrexone and bupropion therapy on the brain’s functional connectivity. Int J Obes (2018). Pubmed
• Yuan K, Zhao M, Yu D, Manza P, Volkow ND, Wang GJ, Tian J. Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers. Neuropsychopharmacology (2018). Pubmed
• Du C, Volkow ND, You J, Park K, Allen CP, Koob GF, Pan Y. Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents. Mol Psychiatry (2018). Pubmed
• Meng Q, Han Y, Ji G, Li G, Hu Y, Liu L, Jin Q, von Deneen KM, Zhao J, Cui G, Wang H, Tomasi D, Volkow ND, Liu J, Nie Y, Zhang Y, Wang GJ. Disrupted topological organization of the frontal-mesolimbic network in obese patients. Brain Imaging Behav. (2018). Pubmed
• Wiers CE, Towb PC, Hodgkinson CA, Shen PH, Freeman C, Miller G, Lindgren E, Shokri-Kojori E, Demiral ŞB, Kim SW, Tomasi D, Sun H, Wang GJ, Goldman D, Volkow ND. Association of genetic ancestry with striatal dopamine D2/D3 receptor availability. Molecular Psychiatry. 2018 Aug;23(8):1711-1716. Pubmed
• Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral ŞB, Diazgranados N, Park L, Liow JS, Pike V, Morse C, Vendruscolo LF, Innis RB, Koob GF, Tomasi D, Wang GJ, Volkow ND. Influence of alcoholism and cholesterol on TSPO binding in brain: PET [¹¹C] PBR28 studies in humans and rodents. Neuropsychopharmacology. 2018 Aug;43(9):1832-1839. Pubmed
• Freeman CR, Zehra A, Ramirez V, Wiers CE, Volkow ND, Wang GJ. Impact of sugar on the body, brain, and behavior. Front Biosci (Landmark Ed). 2018 Jun 1;23:2255-2266. Pubmed
• Manza P, Schwartz G, Masson M, Kann S, Volkow ND, Li CR, Leung HC. Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease. Neurobiol Aging. 2018 Jun;66:12-22. Pubmed
• Ramirez, V, Shokri-Kojori, E, Cabrera, EA, Wiers, CE, Merikangas, K, Tomasi, D, Wang, GJ Volkow, ND Physical activity measured with wrist and ankle accelerometers: Age, gender, and BMI effects. PLoS One. 2018 Apr 27;13(4):e0195996. Pubmed
• Shokri-Kojori E, Wang GJ, Wiers CE, Demiral SB, Guo M, Kim SW, Lindgren E, Ramirez V, Zehra A, Freeman C, Miller G, Manza P, Srivastava T, De Santi S, Tomasi D, Benveniste H, Volkow ND. β-Amyloid accumulation in the human brain after one night of sleep deprivation. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4483-4488. Pubmed
• Chen W, Volkow ND, Li J, Pan Y, Du C. Cocaine Decreases Spontaneous Neuronal Activity and Increases Low-Frequency Neuronal and Hemodynamic Cortical Oscillations. Cereb Cortex. 2018 Apr 18.Pubmed
• Allen CP, Park K, Li A, Volkow ND, Koob GF, Pan Y, Hu XT, Du C. Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats. Addict Biol. 2018 Mar 5. Pubmed
• Manza P, Tomasi D, Volkow ND. Subcortical local functional hyperconnectivity in cannabis dependence. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2018 Mar;3(3):285-293. Pubmed
• Kaczocha M, Azim S, Nicholson J, Rebecchi MJ, Lu Y, Feng T, Romeiser JL, Reinsel R, Rizwan S, Shodhan S, Volkow ND, Benveniste H. Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial. BMC Anesthesiol. 2018 Feb 27;18(1):27. Pubmed
• Dencker D, Molander A, Thomsen M, Schlumberger C, Wortwein G, Weikop P, Benveniste H, Volkow ND, Fink-Jensen A. Ketogenic Diet Suppresses Alcohol Withdrawal Syndrome in Rats. Alcohol Clin Exp Res. 2018 Feb;42(2):270-277. Pubmed
• Gu X, Chen W, You J, Koretsky AP, Volkow ND, Pan Y, Du C. Long-term optical imaging of neurovascular coupling in mouse cortex using GCaMP6f and intrinsic hemodynamic signals. Neuroimage. 2018 Jan 15;165:251-264. Pubmed
• Lindgren E, Gray K, Miller G, Tyler R, Wiers CE, Volkow ND, Wang GJ. Food Addiction: A common neurobiological mechanism with Drug Abuse. Front Biosci (Landmark Ed). 2018 Jan 1;23:811-836. Pubmed
• Zhao J, Tomasi D, Wiers CE, Shokri-Kojori E, Demiral SB, Zhang Y, Volkow ND, Wang GJ. Correlation between traits of emotion-based impulsivity and intrinsic default-mode network activity. Neural Plasticity. 2017;2017:9297621 Pubmed
• Wiers CE, Cabrera EA, Tomasi D, Wong CT, Demiral ŞB, Kim SW, Wang GJ, Volkow ND. Striatal Dopamine D2/D3 Receptor Availability Varies Across Smoking Status. Neuropsychopharmacology. 2017 Nov;42(12):2325-2332. Pubmed
• Michaelides M, Miller ML, DiNieri JA, Gomez JL, Schwartz E, Egervari G, Wang GJ, Mobbs CV, Volkow ND, Hurd YL. Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic-Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement. Neuropsychopharmacology. 2017 Nov;42(12):2365-2376. Pubmed
• Wiers CE, Cabrera E, Tomasi D, Demiral ŞB, Kim SW, Wong CT, Wang GJ, Volkow ND. Methylphenidate-induced dopamine release varies across smoking status. Neuropsychopharmacology. 2017 Nov;42(12):2325-2332. Pubmed
• Benveniste H, Lee H, Volkow ND. The Glymphatic Pathway: Waste Removal from the CNS via Cerebrospinal Fluid Transport. Neuroscientist. 2017 Oct;23(5):454-465. Pubmed
• Tomasi DG, Shokri-Kojori E, Volkow ND. Temporal Evolution of Brain Functional Connectivity Metrics: Could 7 Min of Rest be Enough? Cereb Cortex. 2017 Aug 1;27(8):4153-4165. PubMed
• Shokri-Kojori E, Tomasi D, Wiers CE, Wang GJ, Volkow ND. Linking brain connectivity and behavior after acute and chronic alcohol exposure. Mol Psychiatry, 2017; 22(8):1079. Pubmed
• Shokri-Kojori E, Tomasi D, Wiers CE, Wang GJ, Volkow ND. Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers. 2017 Aug;22(8):1185-1195. Pubmed
• Volkow ND, Wiers CE, Shokri-Kojori E, Tomasi D, Wang GJ, Baler R. Neurochemical and metabolic effects of acute and chronic alcohol in the human brain: studies with positron emission tomography. Neuropharmacology. 2017; Aug 1;122:175-188. Pubmed
• Shumay E, Wiers CE, Shokri-Kojori E, Kim SW, Hodgkinson CA, Sun H, Tomasi D, Wong CT, Weinberger DR, Wang, GJ, Fowler JS, Volkow ND. New repeat polymorphism in the AKT1 gene predicts striatal dopamine D2/D3 receptor availability and stimulant-induced dopamine release in the healthy human brain. J Neurosci. 2017; May 10;37(19):4982-4991. Pubmed
• You J, Volkow ND, Park K, Zhang Q, Clare K, Du C, Pan Y. Cerebrovascular adaptations to cocaine-induced transient ischemic attacks in the rodent brain. JCI Insight. 2017 Mar;2(5):e90809. Pubmed
• Thanos PK, Kim R, Delis F, Rocco MJ, Cho J, Volkow ND. Effects of chronic methamphetamine on psychomotor and cognitive functions and dopamine signaling in the brain. Behav Brain Res. 2017 Mar;320:282-290. Pubmed
• Tomasi DG, Shokri-Kojori E, Volkow ND. Brain Network Dynamics Adhere to a Power Law. Front Neurosci. 2017 Feb 14;11:72. Pubmed
• Cunningham SI, Tomasi D, Volkow ND. Structural and functional connectivity of the precuneus and thalamus to the default mode network. Hum Brain Mapp. 2017 Feb;38(2):938-956. Pubmed
• Tomasi D, Shokri-Kojori E, Wiers CE, Kim SW, Demiral ŞB., Cabrera EA, Lindgren E, Miller G, Wang GJ, Volkow ND. Dynamic brain glucose metabolism identifies anti-correlated networks at rest. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17708692. Pubmed
• Wiers CE, Shokri-Kojori E, Wong CT, Abi-Dargham A, Demiral ŞB, Tomasi D, Wang GJ, Volkow ND. Cannabis Abusers Show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males. Neuropsychopharmacology. 2016;41(10):2596-605. PubMed
• Chen W, Liu P, Volkow ND, Pan Y, Du C. Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity. Mol Psychiatry. 2016 Oct;21(10):1408-16. Pubmed
• Cabrera EA, Wiers CE, Lindgren E, Miller G, Volkow ND, Wang GJ. Neuroimaging the Effectiveness of Substance Use Disorder Treatments. J Neuroimmune Pharmacol. 2016;11(3):408-33. PubMed
• Roux A, Jackson SN, Muller L, Barbacci D, O'Rourke J, Thanos PK, Volkow ND, Balaban C, Schultz JA, Woods AS. Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry. ACS Chem Neurosci. 2016 Aug 17;7(8):1148-56. PubMed
• Zhang Y, Ji G, Xu M, Cai W, Zhu Q, Qian L, Zhang YE, Yuan K, Liu J, Li Q, Cui G, Wang H, Zhao Q, Wu K, Fan D, Gold MS, Tian J, Tomasi D, Liu Y, Nie Y, Wang GJ. Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery. Int J Obes (Lond). 2016 Jun 21. PubMed
• Thanos PK, Kim R, Delis F, Ananth M, Chachati G, Rocco MJ, Masad I, Muniz JA, Grant SC, Gold MS, Cadet JL, Volkow ND. Chronic Methamphetamine Effects on Brain Structure and Function in Rats. PLoS One. 2016 Jun 8;11(6):e0155457. PubMed
• Tomasi D, Wang GJ, Volkow ND. Association between striatal dopamine D2/D3 receptors and brain activation during visual attention: effects of sleep deprivation. Transl Psychiatry. 2016 May 31;6(5):e828. PubMed
• Tomasi D, Shokri-Kojori E, Volkow ND. Temporal Changes in Local Functional Connectivity Density Reflect the Temporal Variability of the Amplitude of Low Frequency Fluctuations in Gray Matter. PLoS One. 2016 Apr 26;11(4):e0154407 PubMed
• Thanos PK, Malave L, Delis F, Mangine P, Kane K, Grunseich A, Vitale M, Greengard P, Volkow ND. Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned. Synapse. 2016;70(7):293-301. PubMed
• Belcher AM, Yen CC, Notardonato L, Ross TJ, Volkow ND, Yang Y, Stein EA, Silva AC, Tomasi D. Functional Connectivity Hubs and Networks in the Awake Marmoset Brain. Front Integr Neurosci. 2016;10:9. PubMed
• Zhang Y, Li Q, Wen X, Cai W, Li G, Tian J, Zhang YE, Liu J, Yuan K, Zhao J, Wang W, Zhou Z, Ding M, Gold MS, Liu Y, Wang GJ. Granger causality reveals a dominant role of memory circuit in chronic opioid dependence. Addict Biol. 2016 Mar 14. PubMed
• Wiers CE, Shumay E, Cabrera E, Shokri-Kojori E, Gladwin TE, Skarda E, Cunningham SI, Kim SW, Wong TC, Tomasi D, Wang GJ, Volkow ND. Reduced sleep duration mediates decreases in striatal D2/D3 receptor availability in cocaine abusers. Transl Psychiatry. 2016 Mar 8;6:e752. PubMed
• Wiers CE, Shokri-Kojori E, Cabrera E, Cunningham S, Wong C, Tomasi D, Wang GJ, Volkow ND. Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers. Neurosci Lett. 2016 Mar 23;617:27-31. PubMed
• Zhang Q, You J, Volkow ND, Choi J, Yin W, Wang W, Pan Y, Du C. Chronic cocaine disrupts neurovascular networks and cerebral function: optical imaging studies in rodents. J Biomed Opt. 2016 Feb;21(2):26006.  PubMed
• Wiers CE, Cabrera E, Skarda E, Volkow ND, Wang GJ. PET imaging for addiction medicine: From neural mechanisms to clinical considerations. Prog Brain Res. 2016;224:175-201. PubMed
• Tomasi D, Shokri-Kojori E, Volkow ND. High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability. Cereb Cortex. 2016;26(7):3249-59. PubMed
• Volkow N.D., Wang G.J., Smith L., Fowler J.S., Telang F., Logan J., Tomasi D. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. Neuroimage. 2015;121:20-8. PubMed
• Tomasi D., Wang G.J., Studentsova Y., Volkow N.D. Dissecting Neural Responses to Temporal Prediction, Attention, and Memory: Effects of Reward Learning and Interoception on Time Perception. Cereb Cortex. 2015 Oct;25(10):3856-67. PubMed
• Wiers C.E., Shumay E., Volkow N.D., Frieling H., Kotsiari A., Lindenmeyer J., Walter H., Bermpohl F. Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism. Transl Psychiatry. 2015;5:e648. PubMed
• Tomasi D., Wang G.J., Volkow N.D. Balanced modulation of striatal activation from D2 /D3 receptors in caudate and ventral striatum: Disruption in cannabis abusers. Hum Brain Mapp. 2015;36(8):3154-66. PubMed  
• Bonaventura J, Navarro G, Casadó-Anguera V, Azdad K, Rea W, Moreno E, Brugarolas M, Mallol J, Canela EI, Lluís C, Cortés A, Volkow ND, Schiffmann SN, Ferré S, Casadó V. Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer. Proc Natl Acad Sci U S A. 2015 Jul;112(27):E3609-18. Pubmed
• Thanos PK, Michaelides M, Subrize M, Miller ML, Bellezza R, Cooney RN, Leggio L, Wang GJ, Rogers AM, Volkow ND, Hajnal A. Roux-en-Y Gastric Bypass Alters Brain Activity in Regions that Underlie Reward and Taste Perception. PLoS One. 2015 Jun;10(6):e0125570. Pubmed
• Volkow N.D., Baler R.D. NOW vs LATER brain circuits: implications for obesity and addiction. Trends Neurosci. 2015 Jun;38(6):345-52. PubMed
• Delis F, Rombola C, Bellezza R, Rosko L, Grandy DK, Volkow ND, Thanos PK. Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters. Front Behav Neurosci. 2015 May;9:118. Pubmed
• Ferré S., Bonaventura J., Tomasi D., Navarro G., Moreno E., Cortés A., Lluís C., Casadó V., Volkow N.D. Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer. Neuropharmacology 2015;104:154-60. PubMed
• Kravitz A.V., Tomasi D., LeBlanc K.H., Baler R., Volkow N.D., Bonci A., Ferré S. Cortico-striatal circuits: Novel therapeutic targets for substance use disorders. Brain Res. 2015; 1628(Pt A):186-98. PubMed
• Volkow N.D., Wang G.J., Logan J., Alexoff D., Fowler J.S., Thanos P.K., Wong C., Casado V., Ferre S., Tomasi D. Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Transl Psychiatry. 2015 Apr 14;5:e549. PubMed
• Fowler J.S., Logan J., Shumay E., Alia-Klein N., Wang G.J., Volkow N.D. Monoamine oxidase: radiotracer chemistry and human studies. J Labelled Comp Radiopharm. 2015 Mar;58(3):51-64. PubMed
• Biegon A., Alexoff D., Kim S.W., Logan J, Pareto D, Schlyer D, Wang GJ, Fowler J. Aromatase Imaging with [N-methyl-C-11]vorozole PET in Healthy Men and Women. J Nucl Med. 2015; 56(4):580-5. PubMed
• Volkow N.D., Wang G.J., Shokri Kojori E., Fowler J.S., Benveniste H., Tomasi D. Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases. J Neurosci. 2015 Feb 18;35(7):3248-55. PubMed
• Fowler JS, Logan J, Volkow ND, Shumay E, McCall-Perez F, Jayne M, Wang GJ, Alexoff DL, Apelskog-Torres K, Hubbard B, Carter P, King P, Fahn S, Gilmor M, Telang F, Shea C, Xu Y, Muench L. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain. Neuropsychopharmacology. 2015 Feb;40(3):650-7. PubMed
• Azim S, Nicholson J, Rebecchi MJ, Galbavy W, Feng T, Reinsel R, Volkow ND, Benveniste H, Kaczocha M. Endocannabinoids and acute pain after total knee arthroplasty. Pain. 2015 Feb;156(2):341-347. Pubmed
• Tomasi D., Wang G.J., Wang R., Caparelli E.C., Logan J., Volkow N.D. Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: association to striatal D2/D3 receptors. Hum Brain Mapp. 2015 Jan;36(1):120-36. PubMed
• Vanicek T, Spies M, Rami-Mark C, Savli M, Höflich A, Kranz GS, Hahn A, Kutzelnigg A, Traub-Weidinger T, Mitterhauser M, Wadsak W, Hacker M, Volkow ND, Kasper S, Lanzenberger R. The norepinephrine transporter in attention-deficit/hyperactivity disorder investigated with positron emission tomography. JAMA Psychiatry. 2014 Dec;71(12):1340-1349. Pubmed
• Pan Y, You J, Volkow ND, Park K, Du C. Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo. Neuroimage. 2014 Dec;103:492-501. Pubmed
• Du C, Volkow ND, Koretsky AP, Pan Y. Low-frequency calcium oscillations accompany deoxyhemoglobin oscillations in rat somatosensory cortex. Proc Natl Acad Sci U S A. 2014 Oct;111(43):E4677-86. Pubmed
• Tomasi D., Wang R., Wang G.J., Volkow N.D. Functional connectivity and brain activation: a synergistic approach. Cereb Cortex. 2014 Oct;24(10):2619-29. PubMed
• Volkow N.D., Tomasi D., Wang G.J., Logan J., Alexoff D.L., Jayne M., Fowler J.S., Wong C., Yin P., Du C. Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. Mol Psychiatry. 2014 Sep;19(9):1037-43. PubMed
• Alia-Klein N., Wang G.J., Preston-Campbell R.N., Moeller S.J., Parvaz M.A., Zhu W., Jayne M.C., Wong C., Tomasi D., Goldstein R.Z., Fowler J.S., Volkow N.D. Mu Opioid Receptor Binding Correlates with Nicotine Dependence and Reward in Smokers. Reactions to media violence: it's in the brain of the beholder. PLoS One. 2014 Sep 10;9(9):e107260. PubMed
• Kim S.W., Fowler J.S., Skolnick P., Muench L., Kang Y., Shea C., Logan J., Kim D., Carter P., King P., Alexoff D., Volkow N.D. Therapeutic doses of buspirone block D3 receptors in the living primate brain. Int J Neuropsychopharmacol. 2014 Aug;17(8):1257-67. PubMed
• Volkow N.D., Wang G.J., Telang F., Fowler J.S., Alexoff D., Logan J., Jayne M., Wong C., Tomasi D. Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3149-56. PubMed
• Seo Y.J., Kang Y., Muench L., Reid A., Caesar S., Jean L., Wagner F., Holson E., Haggarty S.J., Weiss P., King P., Carter P., Volkow N.D., Fowler J.S., Hooker J.M., Kim S.W. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. ACS Chem Neurosci. 2014 Jul 16;5(7):588-96. PubMed
• Moeller S.J., Parvaz M.A., Shumay E., Wu S., Beebe-Wang N., Konova A.B., Misyrlis M., Alia-Klein N., Goldstein R.Z. Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology. Drug Alcohol Depend. 2014 Jul 1;140:17-24. PubMed
• Wang G.J., Tomasi D., Convit A., Logan J., Wong C.T., Shumay E., Fowler J.S., Volkow N.D. BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake. PLoS One. 2014 Jul 7;9(7):e101585. PubMed
• Volkow N.D., Tomasi D., Wang G.J., Studentsova Y., Margus B., Crawford T.O. Brain glucose metabolism in adults with ataxia-telangiectasia and their asymptomatic relatives. Brain. 2014 Jun;137(Pt 6):1753-61. PubMed
• Wang G.J., Tomasi D., Volkow N.D., Wang R., Telang F., Caparelli E.C., Dunayevich E. Effect of combined naltrexone and bupropion therapy on the brain's reactivity to food cues. Int J Obes (Lond). 2014 May;38(5):682-8. PubMed
• Logan J., Kim S.W., Pareto D., Telang F., Wang G.J., Fowler J.S., Biegon A. Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography. Mol Imaging. 2014 May;13(3):1-12. PubMed
• Tomasi D., Volkow N.D. Mapping small-world properties through development in the human brain: disruption in schizophrenia. PLoS One. 2014 Apr 30;9(4):e96176. PubMed
• Tomasi D., Volkow N.D. Functional connectivity of substantia nigra and ventral tegmental area: maturation during adolescence and effects of ADHD. Cereb Cortex. 2014 Apr;24(4):935-44. PubMed
• Moeller S.J., Honorio J., Tomasi D., Parvaz M.A., Woicik P.A., Volkow N.D., Goldstein R.Z. Methylphenidate enhances executive function and optimizes prefrontal function in both health and cocaine addiction. Cereb Cortex. 2014 Mar;24(3):643-53. PubMed
• Volkow N.D., Baler R.D. Addiction science: Uncovering neurobiological complexity. Neuropharmacology. 2014 Jan;76 Pt B:235-49. Review. PubMed
• Moeller S.J., Konova A.B., Parvaz M.A., Tomasi D., Lane R.D., Fort C., Goldstein R.Z. Functional, structural, and emotional correlates of impaired insight in cocaine addiction. JAMA Psychiatry. 2014 Jan;71(1):61-70. PubMed
• Polston JE, Pritchett CE, Tomasko JM, Rogers AM, Leggio L, Thanos PK, Volkow ND, Hajnal A. Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats. PLoS One. 2013 Dec 31;8(12):e83741. Pubmed
• Seo Y.J., Muench L., Reid A., Chen J., Kang Y., Hooker J.M., Volkow N.D., Fowler J.S., Kim S.W. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6700-5. PubMed
• Michaelides M., Anderson S.A., Ananth M., Smirnov D., Thanos P.K., Neumaier J.F., Wang G.J., Volkow N.D., Hurd Y.L. Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks. J Clin Invest. 2013 Dec;123(12):5342-50. PubMed
• Anderson S.A., Michaelides M., Zarnegar P., Ren Y., Fagergren P., Thanos P.K., Wang G.J., Bannon M., Neumaier J.F., Keller E., Volkow N.D., Hurd Y.L. Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. J Clin Invest. 2013 Dec;123(12):5334-41. PubMed
• Volkow N.D., Swanson J.M. Clinical practice: Adult attention deficit-hyperactivity disorder. N Engl J Med. 2013 Nov 14;369(20):1935-44. Review. PubMed
• Park K, Volkow ND, Pan Y, Du C. Chronic cocaine dampens dopamine signaling during cocaine intoxication and unbalances D1 over D2 receptor signaling. J Neurosci. 2013 Oct;33(40):15827-36. Pubmed
• Kim S.W., Hooker J.M., Otto N., Win K., Muench L., Shea C., Carter P., King P., Reid A.E., Volkow N.D., Fowler J.S. Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET. Nucl Med Biol. 2013 Oct;40(7):912-8. PubMed
• Tomasi D., Wang G.J., Volkow N.D. Energetic cost of brain functional connectivity. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13642-7. PubMed
• Volkow N.D., Wang G.J., Tomasi D., Baler R.D. Unbalanced neuronal circuits in addiction. Curr Opin Neurobiol. 2013 Aug;23(4):639-48. PubMed
• Konova A.B., Moeller S.J., Tomasi D., Volkow N.D., Goldstein R.Z. Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction. JAMA Psychiatry. 2013 Aug;70(8):857-68. PubMed
• Tomasi D., Volkow N.D. Brain activation and neurochemistry. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10888-9. PubMed
• Volkow N.D., Baler R.D. Brain imaging biomarkers to predict relapse in alcohol addiction. JAMA Psychiatry. 2013 Jul;70(7):661-3. PubMed
• Moeller S.J., Parvaz M.A., Shumay E., Beebe-Wang N., Konova A.B., Alia-Klein N., Volkow N.D., Goldstein R.Z. Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence. J Neurosci. 2013 Jun 12;33(24):10027-36. PubMed
• Michaelides M., Miller M.L., Subrize M., Kim R., Robison L., Hurd Y.L., Wang G.J., Volkow N.D., Thanos P.K. Limbic activation to novel versus familiar food cues predicts food preference and alcohol intake. Brain Res. 2013 May 28;1512:37-44. PubMed
• Volkow N.D, Tomasi D., Wang G.J., Telang F., Fowler J.S., Goldstein R.Z., Klein N., Wong C., Swanson J.M., Shumay E. Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism. PLoS One. 2013 May 22;8(5):e63492. PubMed
• Wang G.J., Volkow N.D., Wigal T., Kollins S.H., Newcorn J.H., Telang F., Logan J., Jayne M., Wong C.T., Han H., Fowler J.S., Zhu W., Swanson J.M. Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder. PLoS One. 2013 May 15;8(5):e63023. PubMed
• Volkow N.D., Wang G.J., Tomasi D., Baler R.D. The addictive dimensionality of obesity. Biol Psychiatry. 2013 May 1;73(9):811-8. Review. PubMed
• Thanos P, Delis F, Rosko L, Volkow ND. Passive Response to Stress in Adolescent Female and Adult Male Mice after Intermittent Nicotine Exposure in Adolescence. J Addict Res Ther. 2013 Apr 23;Suppl 6:007. Pubmed
• Thanos PK, Robison L, Nestler EJ, Kim R, Michaelides M, Lobo MK, Volkow ND. Mapping brain metabolic connectivity in awake rats with μPET and optogenetic stimulation. J Neurosci. 2013 Apr 10;33(15):6343-9. Pubmed
• Thanos PK, Robison LS, Robinson JK, Michaelides M, Wang GJ, Volkow ND. Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cues. Synapse. 2013 Apr;67(4):171-8. Pubmed
• Volkow N.D., Tomasi D., Wang G.J., Telang F., Fowler J.S., Logan J., Maynard L.J., Wong C.T. Predominance of D2 receptors in mediating dopamine's effects in brain metabolism: effects of alcoholism. J Neurosci. 2013 Mar 6;33(10):4527-35. PubMed
• Thanos PK, Stamos J, Robison LS, Heyman G, Tucci A, Wang GJ, Robinson JK, Anderson BJ, Volkow ND. Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement. Behav Brain Res. 2013 Feb 15;239:8-14. Pubmed
• Tomasi D., Volkow N.D. Striatocortical pathway dysfunction in addiction and obesity: differences and similarities. Crit Rev Biochem Mol Biol. 2013 Jan-Feb;48(1):1-19. Review. PubMed
• Volkow N.D., Kim S.W., Wang G.J., Alexoff D., Logan J., Muench L., Shea C., Telang F., Fowler J.S., Wong C., Benveniste H., Tomasi D. Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain. Neuroimage. 2013 Jan 1;64:277-83. PubMed
• Volkow N.D., Wang G.J., Tomasi D., Baler R.D. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013 Jan;14(1):2-18. Review. PubMed
• Alzghoul L, Bortolato M, Delis F, Thanos PK, Darling RD, Godar SC, Zhang J, Grant S, Wang GJ, Simpson KL, Chen K, Volkow ND, Lin RC, Shih JC. Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice. Neuropharmacology. 2012 Dec;63(7):1208-17. Pubmed
• Thanos PK, Subrize M, Delis F, Cooney RN, Culnan D, Sun M, Wang GJ, Volkow ND, Hajnal A. Gastric bypass increases ethanol and water consumption in diet-induced obese rats. Obes Surg. 2012 Dec;22(12):1884-92. Pubmed
• Honorio J., Tomasi D., Goldstein R.Z., Leung H.C., Samaras D. Can a single brain region predict a disorder? IEEE Trans Med Imaging. 2012 Nov;31(11):2062-72. PubMed
• Moeller S.J., Tomasi D., Woicik P.A., Maloney T., Alia-Klein N., Honorio J., Telang F., Wang G.J., Wang R., Sinha R., Carise D., Astone-Twerell J., Bolger J., Volkow N.D., Goldstein R.Z. Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choice. Addict Biol. 2012 Nov;17(6):1013-25. PubMed
• Volkow N.D. Long-term safety of stimulant use for ADHD: findings from nonhuman primates. Neuropsychopharmacology. 2012 Nov;37(12):2551-2. PubMed
• Moeller S.J., Tomasi D., Honorio J., Volkow N.D., Goldstein R.Z. Dopaminergic involvement during mental fatigue in health and cocaine addiction. Transl Psychiatry.  2012 Oct 23;2:e176. PubMed
• Konova A.B., Moeller S.J., Tomasi D., Parvaz M.A., Alia-Klein N., Volkow N.D., Goldstein R.Z. Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction. Eur J Neurosci. 2012 Oct;36(7):2979-88. PubMed
• Shumay E., Logan J., Volkow N.D., Fowler J.S. Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. Epigenetics. 2012 Oct;7(10):1151-60. PubMed
• Konova A.B., Moeller S.J., Tomasi D., Parvaz M.A., Alia-Klein N., Volkow N.D., Goldstein R.Z. Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction. Eur J Neurosci. 2012 Oct;36(7):2979-88. PubMed
• Wang G.J., Smith L., Volkow N.D., Telang F., Logan J., Tomasi D., Wong C.T., Hoffman W., Jayne M., Alia-Klein N., Thanos P., Fowler J.S. Decreased dopamine activity predicts relapse in methamphetamine abusers.  Mol Psychiatry. 2012 Sep;17(9):918-25. PubMed
• Parvaz M.A., Maloney T., Moeller S.J., Woicik P.A., Alia-Klein N., Telang F., Wang G.J., Squires N.K.,Volkow N.D., Goldstein R.Z. Sensitivity to monetary reward is most severely compromised in recently abstaining cocaine addicted individuals: a cross-sectional ERP study. Psychiatry Res. 2012 Jul 30;203(1):75-82. PubMed
• Parvaz M.A., Konova A.B., Tomasi D., Volkow N.D., Goldstein R.Z. Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward. J Cogn Neurosci. 2012 Jul;24(7):1560-70. PubMed
• Tomasi D., Volkow N.D. Language network: segregation, laterality and connectivity. Mol Psychiatry. 2012 Jul;17(8):759.
• Tomasi D., Volkow N.D. Resting functional connectivity of language networks: characterization and reproducibility. Mol Psychiatry. 2012 Jul;17(8):841-54. doi: 10.1038/mp.2011.177. PubMed 
• Ren H., Du C., Park K., Volkow N.D., Pan Y. Quantitative imaging of red blood cell velocity invivo using optical coherence Doppler tomography. Applied physics letters. 2012 Jun;100(23): 233702-2337024. Pubmed  
• Komatsu DE, Thanos PK, Mary MN, Janda HA, John CM, Robison L, Ananth M, Swanson JM, Volkow ND, Hadjiargyrou M. Chronic exposure to methylphenidate impairs appendicular bone quality in young rats. Bone. 2012 Jun;50(6):1214-22. Pubmed
• Tomasi D., Volkow N.D. Laterality patterns of brain functional connectivity: gender effects. Cereb Cortex. 2012 Jun;22(6):1455-62. doi: 10.1093/cercor/bhr230. PubMed
• Volkow N.D., Muenke M. The genetics of addiction. Hum Genet. 2012 Jun;131(6):773-7. PubMed
• Michaelides M., Thanos P.K., Volkow N.D., Wang G.J. Dopamine-related frontostriatal abnormalities in obesity and binge-eating disorder: emerging evidence for developmental psychopathology. Int Rev Psychiatry. 2012 Jun;24(3):211-8. Review. PubMed
• Volkow N.D., Tomasi D., Wang G.J., Telang F., Fowler J.S., Logan J., Benveniste H., Kim R., Thanos P.K., Ferré S. Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci. 2012 May 9;32(19):6711-7. PubMed
• Tomasi D., Volkow N.D. Aging and functional brain networks. Mol Psychiatry. 2012 May;17(5):471, 549-58. PubMed
• Delis F, Benveniste H, Xenos M, Grandy D, Wang GJ, Volkow ND, Thanos PK. Loss of dopamine D2 receptors induces atrophy in the temporal and parietal cortices and the caudal thalamus of ethanol-consuming mice. Alcohol Clin Exp Res. 2012 May;36(5):815-25. Pubmed
• Tomasi D., Volkow N.D. Gender differences in brain functional connectivity density. Hum Brain Mapp. 2012 Apr;33(4):849-60. PubMed
• Shumay E., Fowler J.S., Wang G.J., Logan J., Alia-Klein N., Goldstein R.Z., Maloney T., Wong C., Volkow N.D. Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. Transl Psychiatry. 2012 Mar 6;2:e86. PubMed
• Tomasi D., Volkow N.D. Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2012 Mar 1;71(5):443-50. PubMed
• Volkow N.D., Baler R.D. Neuroscience. To stop or not to stop? Science. 2012 Feb 3;335(6068):546-8. PubMed
• Volkow N.D., Wang G.J., Tomasi D., Kollins S.H., Wigal T.L., Newcorn J.H., Telang F.W., Fowler J.S., Logan J., Wong C.T., Swanson J.M. Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. J Neurosci. 2012 Jan 18;32(3):841-9. PubMed
• Michaelides M., Thanos P.K., Kim R., Cho J., Ananth M., Wang G.J., Volkow N.D. PET imaging predicts future body weight and cocaine preference. Neuroimage. 2012 Jan 16;59(2):1508-13. PubMed
• Volkow N.D., Wang G.J., Fowler J.S., Tomasi D. Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol. 2012;52:321-36. Review. PubMed
• Volkow N.D., Wang G.J., Fowler J.S., Tomasi D., Baler R. Food and drug reward: overlapping circuits in human obesity and addiction. Curr Top Behav Neurosci. 2012;11:1-24. Review. PubMed
• Michaelides M., Thanos P.K., Volkow N.D., Wang G.J. Translational neuroimaging in drug addiction and obesity. ILAR J. 2012;53(1):59-68. Review. PubMed
• Hajnal A, Zharikov A, Polston JE, Fields MR, Tomasko J, Rogers AM, Volkow ND, Thanos PK. Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism. PLoS One. 2012;7(11);e49121. Pubmed
• Li Z, Xu Y, Warner D, Volkow ND. Alcohol ADME in primates studied with positron emission tomography. PLoS One. 2012;7(10):e46676. Pubmed