Using mice as an animal model of the Wernicke-Korsakoff Syndrome, we are studying the contribution of a mild thiamine deficiency episode and chronic ethanol consumption to neurobiological and behavioral dysfunctions. The project has been developed under the coordination of Dr. D. Lovinger with the collaborations of Dr. A. Salinas and Dr. Y. Mateo (voltammetry), Dr. J. Chancey (operant conditioning task) and Dr. M. Davis and Dr. A. Salinas (striatal and thalamic morphological analyses).