The principal mission of the lab is to develop selective probes and drug-like molecules to enable the study of molecular mechanisms in alcohol associated diseases. The lab aims to use medicinal chemistry and chemical biology approaches to design, synthesize and biologically characterize novel druggable tools for select GPCRs and enzymatic drug targets implicated in pain, inflammatory and fibrotic disorders. Our...

The overarching mission of the lab is to understand the neural basis of cognitive and emotional regulation and how these critical mental processes are mediated by discrete neural circuits and moderated in function by genetic variation and environmental insults, including stress and alcohol.

Human Neurogenetics identifies functional loci that modulate pathways to vulnerability to alcoholism, other addictions, and related psychiatric disorders. To accomplish this it generates clinical datasets and collaborates with multiple laboratories. Its activities encompass human research protocols, large scale SNP detection using massively parallel sequencing, array and capillary electrophoresis based genotyping, in vitro and in vivo functional analyses of receptor variants...

The Laboratory of Cardiovascular Physiology and Tissue Injury (LCPTI) seeks to understand the cellular and molecular mechanisms of the complex interplay of oxidative/nitrative stress, inflammation, lipid signaling (for example endocannabinoid signaling) and cell death pathways (e.g. poly(ADP)-ribose polymerase) in tissue injury, and to identify new therapeutic targets using clinically relevant animal models of disease (e.g., ischemia reperfusion injury, cardiomyopathies/heart failure...

The research focus of the Laboratory of Molecular Signaling (LMS) is to elucidate mechanisms of omega-3 fatty acids, especially docosahexaenoic acid (DHA, 22:6n-3) in neuronal development and function with particular reference to the modulation by ethanol. We investigate biochemical mechanisms by which omega-3 fatty acids and ethanol modify neuronal cell membrane structure, and characterize consequential molecular and cellular signaling involved...

The Section on Neuroendocrinology focuses on the endocannabinoid system, which is involved in the regulation of appetite and the metabolism of lipids, and is therefore implicated in obesity, alcoholism and cardiovascular disease. The Section previously provided the first evidence that mice deficient in the cannabinoid receptor CB1 showed reduced food intake following temporary food deprivation. However, the use of rimonabant...

Native Communities—Alcohol Intervention Review (NativeAIR) is a user-friendly website to help American Indian/Alaska Native (AI/AN) and other Indigenous communities identify and select evidence-based interventions that prevent and address alcohol-related problems.

List of all references cited in the NativeAIR intervention descriptions.

NativeAIR research is made possible by NIAAA and AI/AN tribal leaders and communities.

Each NativeAIR intervention was assessed on nine variables: setting, delivery, participants, staffing, research design, outcomes, cultural engagement, costs, and developmental stage of the research.

A team of alcohol researchers led by Jack Stapleton, M.D., of the Department of Internal Medicine, University of Iowa College of Medicine and the Iowa City Veterans Affairs Medical Center, report in the September 6 New England Journal of Medicine, Volume 345, 2001 ( Effect of co-infection with GB virus type C (Hepatitis G Virus) on survival of HIV-infected individuals...

"The wrong road early," an interview with Dr. Ralph Hingson and HHS HealthBeat. - Listen to the interview with Dr. Ralph Hingson (September 6, 2006) - Read the transcript