National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Scientists have identified new genes and pathways that influence an individual’s typical pattern of brain electrical activity, a trait that may serve as a useful surrogate marker for more genetically complex traits and diseases. One of the genes, for example, was found to be associated with alcoholism. A report of the findings by researchers at the National Institute on Alcohol...
A new drug developed by scientists at the National Institutes of Health limits the progression of liver fibrosis in mice, a hopeful advance against a condition for which there is no current treatment and that often leads to serious liver disease in people with chronic alcoholism and other common diseases. "This study represents an important step towards an effective treatment...
NIH scientists identify possible treatment target for type 2 diabetes Researchers at the National Institutes of Health have clarified in rodent and test tube experiments the role that inflammation plays in type 2 diabetes, and revealed a possible molecular target for treating the disease. The researchers say some natural messenger chemicals in the body are involved in an inflammatory chain...
Mouse study advances knowledge of habitual behavior pathophysiology Daily activities involve frequent transitions between habitual behaviors, such as driving home, and goal-directed behaviors, such as driving to a new destination on unfamiliar roads. An inability to shift between habitual and non-habitual behaviors has been implicated in obsessive-compulsive disorder (OCD), addiction, and other disorders characterized by impaired decision-making. In a new...
Researchers have long known that dopamine, a brain chemical that plays important roles in the control of normal movement, and in pleasure, reward and motivation, also plays a central role in substance abuse and addiction. In a new study conducted in animals, scientists found that a specific dopamine receptor, called D2, on dopamine-containing neurons controls an organism’s activity level and...
Scientists have been developing astounding new tools for exploring neural circuits that underlie brain function throughout the first five years of the National Institutes of Health’s Brain Research through Advancing Innovative Neurotechnologies ® (BRAIN) Initiative. Now, the NIH has announced its continued support for these projects by funding over 180 new BRAIN Initiative awards, bringing the total 2019 budget for...
Girls who suffered childhood sexual abuse are more likely to develop alcoholism later in life if they possess a particular variant of a gene involved in the body’s response to stress, according to a new study led by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). The new finding...
Mission Statement: Focuses on identifying the molecular components of intracellular signaling cascades. Ion Channel Modulation by Second Messenger Systems The Section on Transmitter Signaling focuses primarily on determining the molecular mechanisms underlying G-protein coupled receptor (GPCR) modulation of voltage-gated Ca2+ channels in neuronal systems using electrophysiological, optical, molecular, and biochemical techniques. A consequence of modulation, which usually manifests as a...
Pretreating transplanted livers with the immune molecule interleukin-6 (IL-6) dramatically increased survival of rats receiving organs with fatty degeneration—a common condition in humans that typically reduces transplant viability. The results suggest a means of making it possible to use a higher percentage of available donor livers for transplantation in humans. With over three times as many Americans needing transplants as...