The Laboratory of Cardiovascular Physiology and Tissue Injury (LCPTI) seeks to understand the cellular and molecular mechanisms of the complex interplay of oxidative/nitrative stress, inflammation, lipid signaling (for example endocannabinoid signaling) and cell death pathways (e.g. poly(ADP)-ribose polymerase) in tissue injury, and to identify new therapeutic targets using clinically relevant animal models of disease (e.g., ischemia reperfusion injury, cardiomyopathies/heart failure...

The research focus of the Laboratory of Molecular Signaling (LMS) is to elucidate mechanisms of omega-3 fatty acids, especially docosahexaenoic acid (DHA, 22:6n-3) in neuronal development and function with particular reference to the modulation by ethanol. We investigate biochemical mechanisms by which omega-3 fatty acids and ethanol modify neuronal cell membrane structure, and characterize consequential molecular and cellular signaling involved...

The Section on Neuroendocrinology focuses on the endocannabinoid system, which is involved in the regulation of appetite and the metabolism of lipids, and is therefore implicated in obesity, alcoholism and cardiovascular disease. The Section previously provided the first evidence that mice deficient in the cannabinoid receptor CB1 showed reduced food intake following temporary food deprivation. However, the use of rimonabant...

Native Communities—Alcohol Intervention Review (NativeAIR) is a user-friendly website to help American Indian/Alaska Native (AI/AN) and other Indigenous communities identify and select evidence-based interventions that prevent and address alcohol-related problems.

List of all references cited in the NativeAIR intervention descriptions.

NativeAIR research is made possible by NIAAA and AI/AN tribal leaders and communities.

Each NativeAIR intervention was assessed on nine variables: setting, delivery, participants, staffing, research design, outcomes, cultural engagement, costs, and developmental stage of the research.

Marijuana-like substances (endocannabinoids) intrinsic in animals and humans act at specific receptors on the blood vessel wall to produce vasodilation, the generalized blood vessel dilation seen in many patients with advanced liver cirrhosis, according to an article by George Kunos, M.D., Ph.D., and colleagues in the July 1 issue of Nature Medicine (Volume 7, Number 7; Endocannabinoids acting at vascular...

"The wrong road early," an interview with Dr. Ralph Hingson and HHS HealthBeat. - Listen to the interview with Dr. Ralph Hingson (September 6, 2006) - Read the transcript