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Researchers Identify Alcoholism Subtypes

Analyses of a national sample of individuals with alcohol dependence (alcoholism) reveal five distinct subtypes of the disease, according to a new study by scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). “Our findings should help dispel the popular notion of the ‘typical alcoholic,’” notes first author Howard B...

Naltrexone Approved for Alcoholism Treatment

The National Institute on Alcohol Abuse and Alcoholism welcomes the U.S. Food and Drug Administration announcement of an indication for use of the pharmacologic agent naltrexone (REVIA tm) as a safe and effective adjunct to psychosocial treatments for alcoholism. Naltrexone offers new hope for preventing relapse in many of the more than 1 million Americans treated each year for the...

The Integrative Neuroscience Initiative on Alcoholism (INIA)
Mark Egli, Ph.D. Purpose The National Institute on Alcohol Abuse and Alcoholism (NIAAA) seeks to continue the Integrative Neuroscience Initiative on Alcoholism (INIA), a translational, multidisciplinary, collaborative research effort studying brain mechanisms of excessive alcohol drinking associated with alcohol use disorder (AUD) and the relationship between excessive drinking, stress, and anxiety. The primary goal of INIA is to identify brain...
Behavioral and Drug Therapy Together Help Treat Alcoholism

A new analysis has shown that combined behavioral intervention (CBI), counseling that integrates cognitive-behavioral therapy, motivational enhancement, and techniques to enhance mutual help group participation, used alone in conjunction with naltrexone, a drug approved to help treat alcoholism, can reduce drinking in alcohol-dependent individuals. In this reanalysis of data from the COMBINE Study—the largest pharmacotherapy trial for alcoholism in the...

Gene variants predict treatment success for alcoholism medication

The effectiveness of an experimental treatment for alcoholism depends on the genetic makeup of individuals who receive it, according to a new study supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health. A report of the findings appears online in the American Journal of Psychiatry. “This study represents an important milestone...

Early Drinking Linked to Higher Lifetime Alcoholism Risk

Data from a survey of 43,000 U.S. adults heighten concerns that early alcohol use, independent of other risk factors, may contribute to the risk of developing future alcohol problems. Those who began drinking in their early teens were not only at greater risk of developing alcohol dependence at some point in their lives, they were also at greater risk of...

Brain patterns may help predict relapse risk for alcoholism

Distinct patterns of brain activity are linked to greater rates of relapse among alcohol dependent patients in early recovery, a study has found. The research, supported by the National Institutes of Health, may give clues about which people in recovery from alcoholism are most likely to return to drinking. “Reducing the high rate of relapse among people treated for alcohol...

Gene combinations help predict treatment success for alcoholism medication

NIH-funded study says five-marker genotype panel can guide ondansetron use An experimental treatment for alcohol dependence works better in individuals who possess specific combinations of genes that regulate the function and binding of serotonin, a brain chemical affected by the treatment, according to a study supported by the National Institutes of Health. A report of the finding appears online in...

Study Points to NK1R Blocker as Possible Alcoholism Treatment

Neurokinin-1 receptors (NK1R) are highly expressed in brain areas involved in stress responses and drug reward. In recent years, mounting research evidence has suggested that they may help regulate important aspects of alcohol use. In a new study, researchers at the NIAAA report that a compound that blocks NK1R suppresses alcohol drinking in mice. NIAAA Clinical Director Markus Heilig, M.D...

Gene Variant Increases Risk for Alcoholism Following Childhood Abuse

Girls who suffered childhood sexual abuse are more likely to develop alcoholism later in life if they possess a particular variant of a gene involved in the body’s response to stress, according to a new study led by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). The new finding...

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