Laboratory of Neuroimaging (LNI)
National Institute on Alcohol Abuse and Alcoholism
(NIAAA)
National Institutes of Health

10 Center Drive, Room B2L124: MSC 1013

Bethesda, MD 20892-1013

 

Chief of Laboratory
Nora D. Volkow, MD
Senior Investigator, NIAAA
Director, National Institute on Drug Abuse (NIDA)
Voice: 1 (301) 402-0868
E-mail: nvolkow@nida.nih.gov

Picture of Nora Volkow

Dr. Volkow became Director of the National Institute on Drug Abuse (NIDA) at the National Institutes of Health in May 2003. In addition to her role in NIDA, she is the chief of LNI in NIAAA. Her work has been instrumental in demonstrating that drug addiction is a disease of the human brain. As a research psychiatrist and scientist, Dr. Volkow pioneered the use of brain imaging to investigate the toxic effects and addictive properties of abusable drugs. Her studies have documented changes in the dopamine system affecting, among others, the functions of frontal brain regions involved with motivation, drive, and pleasure in addiction. She has also made important contributions to the neurobiology of obesity, ADHD, and aging. Dr. Volkow has published more than 580 peer-reviewed articles and written more than 90 book chapters and non-peer reviewed manuscripts, and has also edited three books on neuroimaging for mental and addictive disorders.

What we do

LNI uses brain imaging (PET and MRI) to study the neurocircuitry that underlies the rewarding effects of drugs of abuse and of natural reinforcers and their disruption in diseases of addiction and obesity. For this purposes we study how reward circuits modulate executive function (self-control), interoception, and motivation in the normal human brain including an understanding of the role of brain dopamine signaling, functional brain network interactions and genetics. We evaluate the disruption of these interactions in addiction, morbid obesity and ADHD, which are disorders characterized by deficits in self-control and reward sensitivity. We also focus on methodological studies to advance the tools to study function of the human brain including development of PET radiotracers, which is focused on the development of ligands to map epigenetic processes, development of analytical tools to help analyze and understand the underlying physiology behind the dynamically complex patterns of brain networks.

Our Ongoing Research Protocols are

14-AA-0144 Reliability Of The Human Brain Connectome

14-AA-0187 Dopamine Rhythms in Health and Addiction

14-AA-0192 Brain Inflammation and Function in Alcoholism

15-AA-0031 Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness

15-AA-0186  Development of Neuroimaging Methods to Assess the Neurobiology of Addiction

16-AA-0059 Characterization of Brain Amyloid-beta (A-beta) Retention During Wakefulness And Following Emergence From Sleep In Healthy Subjects

 

Current Staff

Picture of Sung Won (Sunny) Kim

Sung Won (Sunny) Kim, PhD
Staff Scientist
Voice: 1 (301) 496-5548
E-mail: kims8@mail.nih.gov

Sunny is an organic chemist as well as chief radiochemist of LNI.  His research focus has been on radiotracer development and its medical application using positron emission tomography (PET).  His research involves the following: 1) design or selection of suitable molecules for radiotracer guided by in vitro biological activity, 2) organic synthesis and radiochemistry for in vivo imaging, and 3) optimization of radiotracers using rodents and non-human primates for translational research to humans. Recently, he completed the in vivo pharmacological profiling of buspirone using multiple dopamine tracers, to evaluate its potential for the treatment of cocaine addiction using a D3R-prefering radiotracer called[11C]PHNO.  Since 2009, he continues his effort for in vivo imaging tool development targeting brain epigenetic biomarkers such as histone deacetylase (HDAC).  Currently, he is also interested in automation and miniaturization of radiosynthesis devices for carbon-11 precursors and compounds, to optimize radiotracer production and streamline laboratory operations.

 

Picture of Dordo Tomasi

Dardo Tomasi, PhD
Staff Scientist
Voice: 1 (301) 496-1589
E-mail: dardo.tomasi@nih.gov

Dardo is an MRI physicist with expertise in gradient coil design, functional MRI and PET imaging. His work focuses on brain metabolism, function, structure and neurochemistry in normal subjects and psychiatric populations. He is interested on novel MRI approaches to map brain function and connectivity with high temporal and spatial resolution.  Recently, Dr. Tomasi developed ultra-fast graph theory methods to compute short- and long-range functional connectivity maps from "resting-state" echo-planar imaging time series that when used in large public image databases revealed pronounced gender and aging effects on the brain's functional architecture.

 

Picture of Gene-Jack Wang

Gene-Jack Wang, MD
Senior Clinician & Clinical Director
Voice: 1-301-496-5012
E-mail: gene-jack.wang@nih.gov

Gene-Jack is a board certified Nuclear Medicine physician. He joined NIAAA as a senior clinician and the clinical director of LNI in 2013. Prior to his current appointment, he was a professor of Radiology at Stony Brook University, a senior scientist and chairman of medical department at Brookhaven National Laboratory and held a joint appointment as a professor of Psychiatry at Mount Sinai School of Medicine. His research focuses on the application of PET and functional MRI to the study of various brain disorders. He is interested in using PET to study the neuro-psychiatric mechanisms and manifestations of alcoholism, drug addiction, ADHD, obesity and eating disorder in humans. Using PET, he first reported similarity of human brain circuits’ disruption in drug addiction and in obesity.

Picture of Karen Torres

Karen Torres
Protocol Coordinator
Voice: 1 (301) 496-4186
E-mail: karen.torres@nih.gov

Karen joined the Laboratory of Neuroimaging (LNI) as a Clinical Protocol Coordinator in 2010. Previous to coming on board in the NIAAA/LNI, she performed the same role starting in 2003 when the NIAAA/LNI was first established at the Brookhaven National Laboratory (BNL) in Upton, NY. Karen's role as the Clinical Protocol Coordinator covers working on and managing protocols starting from inception through, scientific review, IRB submissions, IND preparation and protocol implementation. She organizes and schedules scientific seminars, presentations and talks by current lab staff as well as invited guests. In addition to these activities, she manages the NIAAA calendar for the Laboratory Chief of LNI.

 

Lori Talagala

Lori Talagala, BS
MRI Technologist
Voice: 1 (301) 496-1589
E-mail: lori.talagala@nih.gov

Lori is certified in Radiography and Magnetic Resonance Imaging by the American Registry of Radiologic Technologists (ARRT) and has been involved in MRI since 1988. Prior to working with LNI, Lori worked as a technologist and instructor at the Pittsburgh NMR Institute/University of Pittsburgh Medical Center, and was CT/MRI Supervisor at Latrobe Area Hospital. Lori served on the Practice Analysis Advisory Committee for the development of the MRI registry exam and as an item writer for the MRI registry exam. She also served as Secretary of the Section for Magnetic Resonance Technologists (SMRT).

Christopher T. Wong, BS, CNMT
Data Manager
Voice: 1 (301) 496-4186
E-mail: chris.wong@nih.gov

Min Guo

Min Guo, PhD
Post-Doctoral IRTA Fellow
Voice: 1 (301) 496-5548
E-mail: min.guo2@nih.gov

Min received his B.S. and M.S. in organic chemistry from Nanjing University, China. Then he decided to study abroad and got his Ph.D. in organic chemistry and biochemistry from University of Maryland, College Park. His Ph.D. work involved synthesis and evaluate bioactive small molecules to modulate bacteria communication. In August 2015, he joined LNI as a postdoctoral fellow under the advice of Dr. Sung Won Kim. He is interested in developing new radiotracers as diagnostic tools for neurodegenerative diseases.

 

Picture of Ehsan Shokri Kojori

Ehsan Shokri Kojori, PhD
Research Fellow
Voice: 1 (301) 451-3020
E-mail: ehsan.shokrikojori@nih.gov

Ehsan joined the lab as a postdoctoral IRTA fellow in August 2014 and became a Research Fellow in May 2016. He earned a PhD degree in cognitive neuroscience from the University of Texas at Dallas in Spring 2014. Ehsan also has a background in electrical engineering and signal processing. His interests include combining brain imaging modalities (e.g., fMRI, DTI, and PET) and behavioral measurements to understand the neurocognitive underpinnings of goal directed behavior. His current work involves studying how addiction and alcohol abuse affect efficiency and energetic cost of the brain networks. He is also working on developing novel methodologies to better characterize anatomical and functional brain connectivity indices.

 

Picture of Corinde Wiers

Corinde Wiers, PhD
Research Fellow
Voice: 301-451-3021
E-mail: corinde.wiers@nih.gov

Corinde joined the LNI as a Postdoctoral IRTA Fellow in September 2014, and became a Research Fellow in September 2016. She studied psychology and psychobiology at the University of Amsterdam (Netherlands) and Sussex University (UK), and earned her PhD in psychology from the Berlin School of Mind and Brain and Free University Berlin (Germany). Her research investigates cognitive and neurobiological processes involved in addiction, using fMRI, PET and psychophysics. She currently works on how genetic and epigenetic markers relate to brain functioning in drug abusers.

 

Picture of Sukru Baris Demiral, Ph.D

Sukru Baris Demiral, PhD
Post-doctoral IRTA Fellow
Voice: (301) 402-5861
E-mail: sukru.demiral@nih.gov

Baris received his Ph.D. from the University of Leipzig, Faculty of Biosciences, Pharmacy and Psychology, Germany, through a joint project in Max Planck Institute Cognitive and Brain Sciences. He studied physics in his undergraduate studies, then conducted cognitive modeling work and neurolinguistics research in the following years. His developing interests in neurophysiology, neurotransmitter dynamics, addiction, motivation, and genetics led him to work in a number of neurophysiology labs as a post-doc. He joined LNI in early 2016, and he is currently exploring the effects of arousal, sleep, and sleep deprivation on neural dynamics, brain metabolism, and health via multi-modal imaging including fMRI, PET and simultaneous EEG-fMRI techniques.  

 

Else Lindgren

Elsa Lindgren, BS
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 402-0910
E-mail: elsa.lindgren@nih.gov

Elsa received her B.S. in Neuroscience and Behavior from the University of New Hampshire in May 2015, and has been a post-baccalaureate fellow with LNI since July 2015. Her responsibilities include screening research subjects, administering clinical interviews and neuropsychological assessments, and conducting fMRI and PET imaging sessions. Elsa plans to attend medical school in the future.

 

Gregg Miller

Gregg Miller, BS
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 451-2116
E-mail: gregg.miller@nih.gov

Gregg received his B.A. in neuroscience from Boston University in May 2015. He joined the Laboratory of Neuroimaging in July 2015 and is involved in the recruitment and screening of study participants, administering neuropsychological testing, and conducting fMRI and PET scans. Gregg plans to attend medical school in the future.

 

Ryan Tyler

Ryan Tyler, BS
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 496-5548
E-mail: ryan.tyler@nih.gov

Ryan received his B.S. in Chemistry at the College of William and Mary in May 2015, and joined the Laboratory of Neuroimaging the following August.  He plans on pursuing a PhD in neuroscience, or a related field. 

 

Clara Freeman

Clara Freeman, BA
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 451-2401
E-Mail: clara.freeman@nih.gov

 
Clara received her B.A. in psychology from Cornell University in May 2016, and joined the Laboratory of Neuroimaging in the following July. She plans to pursue a PhD in clinical psychology in the future.   
 
 
 
Anna Zehra
Amna Zehra, BS
Post-Baccalaureate IRTA Fellow
Voice: 1 (301) 451-1361
 
Amna received her B.S. in Psychology from University of Maryland, College Park in May 2016 and joined the Laboratory of Neuroimaging in July 2016. Amna plans to attend medical school in the future.
 
 
 
Veronica Ramirez
Veronica Ramirez, BA
Post-baccalaureate NIH UGSP Fellow
Voice: (401) 451-1504
 
Veronica received her B.A. in Psychology from the University of San Diego. She was awarded the NIH Undergraduate Scholarship Program (UGSP) in 2014 and joined LNI as a postbac in May 2016. Her research interests include the neuromechanisms of addiction and value based decision-making. She assists in fMRI and PET study sessions, clinical interviews, neuropsychological testing, and data analyses/management. She currently works on combining actinography with neuropsychological measures to study correlations of physical activity and psychological traits. Her goal is to pursue a PhD in neuroscience/psychology and to continue doing research on brain and behavior.
 
 

 

Special Volunteers

Picture of Yeon Joo Jang

Yeon Joo Jang, PhD
Voice: 1 (301) 402-0910
E-mail: yeonjoo.jang@nih.gov

After getting M.S. degree in the field of molecular biology in Seoul, South Korea, Yeon worked on as a researcher to understand the molecular mechanisms of Parkinson’s disease by using both cellular system and in vivo system. To pursuit Ph. D degree in United States, Yeon studied on molecular mechanisms driven by oncogene induced signaling pathway in SUNY, State Univ. of New York in Stony Brook. Currently she is helping to understand the mechanism of Alcohol induced neuroinflammation with biological tools.

 

Jizheng Zhao
Jizheng Zhao, PhD
Voice: 1 (202) 781-9928 
 
Jizheng is a lecturer of North West Agriculture & Forestry University, Shaanxi, China. He joined the lab as a special volunteer in February 2016 with a support from Chinese Scholarship Council. He received PhD from Xidian University, China in Pattern Recognition and Intelligent System. His research interests focus on neural mechanisms underlying obesity bariatric surgery.
 
 

 

Walter Reed Psychiatry Resident Research Rotation

Kyle Gray, MD, PGY2 Psychiatry Resident, starting 2015

Parmalee C. Towb, MD, PhD, PGY4 Psychiatry Resident, starting 2016

Shram Shukla, MD, PGY1 Psychiatry Resident, starting 2016

 

Collaborators

Linda Chang, MD, Professor of Medicine; Program Director, Neuroscience and MR Research, University of Hawaii

Thomas Ernst, PhD, Professor of Medicine, University of Hawaii

Joanna S. Fowler, PhD, Emeritus Chemist, Brookhaven National Laboratory

Helene D. Benveniste, MD, PhD, Professor of Anesthesiology, Yale University.

Samantha Iren​e Scott, PhD, Research Scientist, Vasoptic Medical Inc.

 

Alumni

Stephen Lee, MS
Graduate student, 2014-2015
Compliance officer, US consumer product safety commission

Emily Skarda, BS
Post-Baccalaureate IRTA Fellow, 2014-2015
Medical student, School of Medicine, University of Chicago

Samantha Irene Scott, PhD
Post-Doctoral IRTA Fellow, 2014-2015
Research Scientist, Vasoptic Medical Inc.

Elizabeth Cabrera, BS
Post-Baccalaureate IRTA Fellow, 2014-2016
Medical student, School of Medicine, University of Pittsburgh

Kristina Murani, BA
NIH Graduate Summer Opportunity to Advance Research, 2016
PhD Candidate, American University

In Memory
Elena Shumay, MD, PhD

Elene Shumay

Elena was a staff geneticist of LNI. Her interests were in identifying genetic-and epigenetic polymorphisms that could explain individual differences in brain imaging phenotype.  Along with analysis of the accepted genetic markers, she interested in discovering new polymorphism in the known candidate genes as well as in exploring previously unspecified genetic targets and assessing them as putative biomarkers.

Read more>>>

 

 

 

Selected Publications

  • Wiers CE, Shokri-Kojori E, Wong CT, Abi-Dargham A, Demiral ŞB, Tomasi D, Wang GJ, Volkow ND. Cannabis Abusers Show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males. Neuropsychopharmacology. 2016;41(10):2596-605. PubMed
  • Cabrera EA, Wiers CE, Lindgren E, Miller G, Volkow ND, Wang GJ. Neuroimaging the Effectiveness of Substance Use Disorder Treatments. J Neuroimmune Pharmacol. 2016;11(3):408-33. PubMed
  • Tomasi DG, Shokri-Kojori E, Volkow ND. Temporal Evolution of Brain Functional Connectivity Metrics: Could 7 Min of Rest be Enough? Cereb Cortex. 2016 Aug 12. PubMed
  • Roux A, Jackson SN, Muller L, Barbacci D, O'Rourke J, Thanos PK, Volkow ND, Balaban C, Schultz JA, Woods AS. Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry. ACS Chem Neurosci. 2016 Aug 17;7(8):1148-56. PubMed
  • Zhang Y, Ji G, Xu M, Cai W, Zhu Q, Qian L, Zhang YE, Yuan K, Liu J, Li Q, Cui G, Wang H, Zhao Q, Wu K, Fan D, Gold MS, Tian J, Tomasi D, Liu Y, Nie Y, Wang GJ. (2016) Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery. Int J Obes (Lond). 2016 Jun 21. PubMed
  • Zhang Y, Li Q, Wen X, Cai W, Li G, Tian J, Zhang YE, Liu J, Yuan K, Zhao J, Wang W, Zhou Z, Ding M, Gold MS, Liu Y, Wang GJ. (2016) Granger causality reveals a dominant role of memory circuit in chronic opioid dependence. Addict Biol. 2016 Mar 14. PubMed
  • Thanos PK, Kim R, Delis F, Ananth M, Chachati G, Rocco MJ, Masad I, Muniz JA, Grant SC, Gold MS, Cadet JL, Volkow ND. Chronic Methamphetamine Effects on Brain Structure and Function in Rats. PLoS One. 2016 Jun 8;11(6):e0155457. PubMed
  • Tomasi D, Wang GJ, Volkow ND. Association between striatal dopamine D2/D3 receptors and brain activation during visual attention: effects of sleep deprivation. Transl Psychiatry. 2016 May 31;6(5):e828. PubMed
  • Tomasi D, Shokri-Kojori E, Volkow ND. Temporal Changes in Local Functional Connectivity Density Reflect the Temporal Variability of the Amplitude of Low Frequency Fluctuations in Gray Matter. PLoS One. 2016 Apr 26;11(4):e0154407 PubMed
  • Shokri-Kojori E, Tomasi D, Wiers CE, Wang GJ, Volkow ND. Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers. Mol Psychiatry. 2016 Mar 29. PubMed
  • Thanos PK, Malave L, Delis F, Mangine P, Kane K, Grunseich A, Vitale M, Greengard P, Volkow ND. (2016) Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned. Synapse. 2016;70(7):293-301. PubMed
  • Belcher AM, Yen CC, Notardonato L, Ross TJ, Volkow ND, Yang Y, Stein EA, Silva AC, Tomasi D. Functional Connectivity Hubs and Networks in the Awake Marmoset Brain. Front Integr Neurosci. 2016;10:9. PubMed
  • Wiers CE, Shumay E, Cabrera E, Shokri-Kojori E, Gladwin TE, Skarda E, Cunningham SI, Kim SW, Wong TC, Tomasi D, Wang GJ, Volkow ND. Reduced sleep duration mediates decreases in striatal D2/D3 receptor availability in cocaine abusers. Transl Psychiatry. 2016 Mar 8;6:e752. PubMed
  • Wiers CE, Shokri-Kojori E, Cabrera E, Cunningham S, Wong C, Tomasi D, Wang GJ, Volkow ND. Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers. Neurosci Lett. 2016 Mar 23;617:27-31. PubMed
  • Zhang Q, You J, Volkow ND, Choi J, Yin W, Wang W, Pan Y, Du C. Chronic cocaine disrupts neurovascular networks and cerebral function: optical imaging studies in rodents. J Biomed Opt. 2016 Feb;21(2):26006.  PubMed
  • Wiers CE, Cabrera E, Skarda E, Volkow ND, Wang GJ. PET imaging for addiction medicine: From neural mechanisms to clinical considerations. Prog Brain Res. 2016;224:175-201. PubMed
  • Tomasi D, Shokri-Kojori E, Volkow ND. High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability. Cereb Cortex. 2016;26(7):3249-59. PubMed
  • Volkow N.D., Wang G.J., Smith L., Fowler J.S., Telang F., Logan J., Tomasi D. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. Neuroimage. 2015;121:20-8. PubMed
  • Tomasi D., Wang G.J., Studentsova Y., Volkow N.D. Dissecting Neural Responses to Temporal Prediction, Attention, and Memory: Effects of Reward Learning and Interoception on Time Perception. Cereb Cortex. 2015;25(10):3856-67. PubMed
  • Wiers C.E., Shumay E., Volkow N.D., Frieling H., Kotsiari A., Lindenmeyer J., Walter H., Bermpohl F. Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism. Transl Psychiatry. 2015;5:e648. PubMed
  • Tomasi D., Wang G.J., Volkow N.D. Balanced modulation of striatal activation from D2 /D3 receptors in caudate and ventral striatum: Disruption in cannabis abusers. Hum Brain Mapp. 2015;36(8):3154-66. PubMed
  • Tomasi D., Shokri-Kojori E., Volkow N.D. High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability. Cereb Cortex. 2016; 26(7):3249-59. PubMed
  • Volkow N.D., Baler R.D. NOW vs LATER brain circuits: implications for obesity and addiction. Trends Neurosci. 2015 Jun;38(6):345-52. PubMed
  • Ferré S., Bonaventura J., Tomasi D., Navarro G., Moreno E., Cortés A., Lluís C., Casadó V., Volkow N.D. Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer. Neuropharmacology. 2015;104:154-60. PubMed
  • Volkow N.D., Koob G., Baler R. Biomarkers in substance use disorders. ACS Chem Neurosci. 2015 Apr 15;6(4):522-5. PubMed
  • Kravitz A.V., Tomasi D., LeBlanc K.H., Baler R., Volkow N.D., Bonci A., Ferré S. Cortico-striatal circuits: Novel therapeutic targets for substance use disorders. Brain Res. 2015; 1628(Pt A):186-98. PubMed
  • Volkow N.D., Wang G.J., Logan J., Alexoff D., Fowler J.S., Thanos P.K., Wong C., Casado V., Ferre S., Tomasi D. Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Transl Psychiatry. 2015 Apr 14;5:e549. PubMed
  • Fowler J.S., Logan J., Shumay E., Alia-Klein N., Wang G.J., Volkow N.D. Monoamine oxidase: radiotracer chemistry and human studies. J Labelled Comp Radiopharm. 2015 Mar;58(3):51-64. PubMed
  • Volkow N.D., Baler R. Beliefs modulate the effects of drugs on the human brain.  Beliefs modulate the effects of drugs on the human brain.  Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2301-2. PubMed
  • Biegon A., Alexoff D., Kim S.W., Logan J, Pareto D, Schlyer D, Wang GJ, Fowler J. Aromatase Imaging with [N-methyl-C-11]vorozole PET in Healthy Men and Women. J Nucl Med. 2015; 56(4):580-5. PubMed
  • Volkow N.D., Wang G.J., Shokri Kojori E., Fowler J.S., Benveniste H., Tomasi D. Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases. J Neurosci. 2015 Feb 18;35(7):3248-55. PubMed
  • Fowler JS, Logan J, Shumay E, Alia-Klein N, Wang GJ, Volkow ND. Monoamine oxidase: radiotracer chemistry and human studies. J Labelled Comp Radiopharm. 2015; 58(3):51-64. PubMed
  • Fowler JS, Logan J, Volkow ND, Shumay E, McCall-Perez F, Jayne M, Wang GJ, Alexoff DL, Apelskog-Torres K, Hubbard B, Carter P, King P, Fahn S, Gilmor M, Telang F, Shea C, Xu Y, Muench L. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain. Neuropsychopharmacology. 2015 Feb;40(3):650-7. PubMed
  • Tomasi D., Wang G.J., Wang R., Caparelli E.C., Logan J., Volkow N.D. Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: association to striatal D2/D3 receptors. Hum Brain Mapp. 2015 Jan;36(1):120-36. PubMed
  • Tomasi D., Wang G.J., Studentsova Y., Volkow N.D. Dissecting Neural Responses to Temporal Prediction, Attention, and Memory: Effects of Reward Learning and Interoception on Time Perception. Cereb Cortex. 2014 Nov 11. pii: bhu269. [Epub ahead of print] PubMed
  • Tomasi D., Wang R., Wang G.J., Volkow N.D. Functional connectivity and brain activation: a synergistic approach. Cereb Cortex. 2014 Oct;24(10):2619-29. PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Logan J., Alexoff D.L., Jayne M., Fowler J.S., Wong C., Yin P., Du C. Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. Mol Psychiatry. 2014 Sep;19(9):1037-43. PubMed
  • Kim S.W., Fowler J.S., Skolnick P., Muench L., Kang Y., Shea C., Logan J., Kim D., Carter P., King P., Alexoff D., Volkow N.D. Therapeutic doses of buspirone block D3 receptors in the living primate brain. Int J Neuropsychopharmacol. 2014 Aug;17(8):1257-67. PubMed
  • Volkow N.D., Wang G.J., Telang F., Fowler J.S., Alexoff D., Logan J., Jayne M., Wong C., Tomasi D. Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3149-56. PubMed
  • Seo Y.J., Kang Y., Muench L., Reid A., Caesar S., Jean L., Wagner F., Holson E., Haggarty S.J., Weiss P., King P., Carter P., Volkow N.D., Fowler J.S., Hooker J.M., Kim S.W. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. ACS Chem Neurosci. 2014 Jul 16;5(7):588-96. PubMed
  • Logan J., Kim S.W., Pareto D., Telang F., Wang G.J., Fowler J.S., Biegon A. Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography. Mol Imaging. 2014 May;13(3):1-12. PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Studentsova Y., Margus B., Crawford T.O. Brain glucose metabolism in adults with ataxia-telangiectasia and their asymptomatic relatives. Brain. 2014 Jun;137(Pt 6):1753-61. PubMed
  • Wang G.J., Tomasi D., Volkow N.D., Wang R., Telang F., Caparelli E.C., Dunayevich E. Effect of combined naltrexone and bupropion therapy on the brain's reactivity to food cues. Int J Obes (Lond). 2014 May;38(5):682-8. PubMed
  • Moeller S.J., Parvaz M.A., Shumay E., Wu S., Beebe-Wang N., Konova A.B., Misyrlis M., Alia-Klein N., Goldstein R.Z. Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology. Drug Alcohol Depend. 2014 Jul 1;140:17-24. PubMed
  • Tomasi D., Volkow N.D. Functional connectivity of substantia nigra and ventral tegmental area: maturation during adolescence and effects of ADHD. Cereb Cortex. 2014 Apr;24(4):935-44. PubMed
  • Moeller S.J., Honorio J., Tomasi D., Parvaz M.A., Woicik P.A., Volkow N.D., Goldstein R.Z. Methylphenidate enhances executive function and optimizes prefrontal function in both health and cocaine addiction. Cereb Cortex. 2014 Mar;24(3):643-53. PubMed
  • Volkow N.D., Baler R.D. Addiction science: Uncovering neurobiological complexity. Neuropharmacology. 2014 Jan;76 Pt B:235-49. Review. PubMed
  • Moeller S.J., Konova A.B., Parvaz M.A., Tomasi D., Lane R.D., Fort C., Goldstein R.Z. Functional, structural, and emotional correlates of impaired insight in cocaine addiction. JAMA Psychiatry. 2014 Jan;71(1):61-70. PubMed
  • Alia-Klein N., Wang G.J., Preston-Campbell R.N., Moeller S.J., Parvaz M.A., Zhu W., Jayne M.C., Wong C., Tomasi D., Goldstein R.Z., Fowler J.S., Volkow N.D. Mu Opioid Receptor Binding Correlates with Nicotine Dependence and Reward in Smokers. Reactions to media violence: it's in the brain of the beholder. PLoS One. 2014 Sep 10;9(9):e107260. PubMed
  • Wang G.J., Tomasi D., Convit A., Logan J., Wong C.T., Shumay E., Fowler J.S., Volkow N.D. BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake. PLoS One. 2014 Jul 7;9(7):e101585. PubMed
  • Tomasi D., Volkow N.D. Mapping small-world properties through development in the human brain: disruption in schizophrenia. PLoS One. 2014 Apr 30;9(4):e96176. PubMed
  • Seo Y.J., Muench L., Reid A., Chen J., Kang Y., Hooker J.M., Volkow N.D., Fowler J.S., Kim S.W. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6700-5. PubMed
  • Michaelides M., Anderson S.A., Ananth M., Smirnov D., Thanos P.K., Neumaier J.F., Wang G.J., Volkow N.D., Hurd Y.L. Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks. J Clin Invest. 2013 Dec;123(12):5342-50. PubMed
  • Anderson S.A., Michaelides M., Zarnegar P., Ren Y., Fagergren P., Thanos P.K., Wang G.J., Bannon M., Neumaier J.F., Keller E., Volkow N.D., Hurd Y.L. Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. J Clin Invest. 2013 Dec;123(12):5334-41. PubMed
  • Volkow N.D., Swanson J.M. Clinical practice: Adult attention deficit-hyperactivity disorder. N Engl J Med. 2013 Nov 14;369(20):1935-44. Review. PubMed
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  • Tomasi D., Volkow N.D. Brain activation and neurochemistry. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10888-9. PubMed
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  • Volkow N.D, Tomasi D., Wang G.J., Telang F., Fowler J.S., Goldstein R.Z., Klein N., Wong C., Swanson J.M., Shumay E. Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism. PLoS One. 2013 May 22;8(5):e63492. PubMed
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  • Volkow N.D., Wang G.J., Tomasi D., Baler R.D. The addictive dimensionality of obesity. Biol Psychiatry. 2013 May 1;73(9):811-8. Review. PubMed
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  • Volkow N.D., Kim S.W., Wang G.J., Alexoff D., Logan J., Muench L., Shea C., Telang F., Fowler J.S., Wong C., Benveniste H., Tomasi D. Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain. Neuroimage. 2013 Jan 1;64:277-83. PubMed
  • Volkow N.D., Wang G.J., Tomasi D., Baler R.D. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013 Jan;14(1):2-18. Review. PubMed
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  • Volkow N.D. Long-term safety of stimulant use for ADHD: findings from nonhuman primates. Neuropsychopharmacology. 2012 Nov;37(12):2551-2. PubMed
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  • Shumay E., Logan J., Volkow N.D., Fowler J.S. Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. Epigenetics. 2012 Oct;7(10):1151-60. PubMed
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  • Wang G.J., Smith L., Volkow N.D., Telang F., Logan J., Tomasi D., Wong C.T., Hoffman W., Jayne M., Alia-Klein N., Thanos P., Fowler J.S. Decreased dopamine activity predicts relapse in methamphetamine abusers.  Mol Psychiatry. 2012 Sep;17(9):918-25. PubMed
  • Parvaz M.A., Maloney T., Moeller S.J., Woicik P.A., Alia-Klein N., Telang F., Wang G.J., Squires N.K.,Volkow N.D., Goldstein R.Z. Sensitivity to monetary reward is most severely compromised in recently abstaining cocaine addicted individuals: a cross-sectional ERP study. Psychiatry Res. 2012 Jul 30;203(1):75-82. PubMed
  • Parvaz M.A., Konova A.B., Tomasi D., Volkow N.D., Goldstein R.Z. Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward. J Cogn Neurosci. 2012 Jul;24(7):1560-70. PubMed
  • Tomasi D., Volkow N.D. Language network: segregation, laterality and connectivity. Mol Psychiatry. 2012 Jul;17(8):759. PubMed
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  • Volkow N.D., Muenke M. The genetics of addiction. Hum Genet. 2012 Jun;131(6):773-7. PubMed
  • Michaelides M., Thanos P.K., Volkow N.D., Wang G.J. Dopamine-related frontostriatal abnormalities in obesity and binge-eating disorder: emerging evidence for developmental psychopathology. Int Rev Psychiatry. 2012 Jun;24(3):211-8. Review. PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Telang F., Fowler J.S., Logan J., Benveniste H., Kim R., Thanos P.K., Ferré S. Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci. 2012 May 9;32(19):6711-7. PubMed
  • Tomasi D., Volkow N.D. Aging and functional brain networks. Mol Psychiatry. 2012 May;17(5):471, 549-58. PubMed
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  • Tomasi D., Volkow N.D. Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2012 Mar 1;71(5):443-50. PubMed
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  • Michaelides M., Thanos P.K., Kim R., Cho J., Ananth M., Wang G.J., Volkow N.D. PET imaging predicts future body weight and cocaine preference. Neuroimage. 2012 Jan 16;59(2):1508-13. PubMed
  • Volkow N.D., Wang G.J., Fowler J.S., Tomasi D. Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol. 2012;52:321-36. Review. PubMed
  • Volkow N.D., Wang G.J., Fowler J.S., Tomasi D., Baler R. Food and drug reward: overlapping circuits in human obesity and addiction. Curr Top Behav Neurosci. 2012;11:1-24. Review. PubMed
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