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National Institute on Alcohol Abuse and Alcoholism (NIAAA)

News Release

Sex hormone-sensitive gene complex linked to premenstrual mood disorder
For Release
Dysregulated cellular response to estrogen and progesterone suspected. National Institutes of Health (NIH) researchers have discovered molecular mechanisms that may underlie a woman’s susceptibility to disabling irritability, sadness, and anxiety in the days leading up to her menstrual period. Such premenstrual dysphoric disorder (PMDD) affects 2 to 5 percent of women of reproductive age, whereas less severe premenstrual syndrome (PMS)...
Guidelines for establishing and operating a Data and Safety Monitoring Board (DSMB)
Introduction This guidance is intended to assist the National Institute on Alcohol Abuse and Alcoholism (NIAAA)-supported extramural researchers in establishing and operating a Data and Safety Monitoring Board (DSMB) for clinical trials [1] funded by NIAAA. The purpose of the DSMB is to provide oversight and monitoring of the conduct of clinical trials to ensure the safety of participants and...
Transcript: Rethinking Drinking - The Most Important Drive of the Big Game
title="Rethinking Drinking - The Most Important Drive of the Big Game" video="" width="560" your="" " The following is a description of the video: Rethinking Drinking - The Most Important Drive of the Big Game . Text in Video Image Descriptions Text: The most important drive of the Big Game? Image of a green and white football field. The image pans...
Sophie Haven

Sophie Haven Post-Bacc IRTA Sophie Haven is a post-bac IRTA working in the Section on Nutritional Neurosciences at the National Institute on Alcohol Abuse and Alcoholism. Her role within this section consists of assisting with the Neuroimaging, Omega-3, and Reward in Adults with ADHD (NORAA) trial. This trial will be investigating the effects of Omega-3 highly unsaturated fatty acids in...

NIAAA Spectrum: Translation in Stress Research - of Mice and Men

Both humans and animals experience stress. Ideally, stress serves as a survival tool, allowing organisms to adapt and overcome adversity in an unpredictable environment. As a result, higher-order animals have developed complex systems to perceive, react to, and adapt to psychological stress, ensuring that they can respond to environmental dangers that might harm or kill them. But for some, the...

NIAAA Spectrum: Anxiety and Depression Predict Relapse in AUD Patients with Chronic Pain

Interventions to reduce anxiety and depression may help prevent relapse in individuals with chronic pain who are recovering from alcohol use disorder (AUD). This conclusion comes from a recent study in which investigators reanalyzed data collected from people with chronic pain who participated in one of two major clinical trials on alcohol treatment, one in the United States and one...

NIAAA Spectrum: Clinical Course of Alcohol Use Disorder in Young Adult Native and Mexican Americans

In a recent study, Cindy L. Ehlers, Ph.D., and colleagues examined the clinical course of alcohol use disorder (AUD)—as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM–5)—in a sample of young adult (ages 18–30) individuals of Mexican American (MA) and Native American (NA) descent. Face-to-face interviews using the Semi-Structured Assessment for the Genetics of Alcoholism...

NIAAA Spectrum: NESARC-III: Adults Are Drinking More Alcohol Than a Decade Ago

Adults drank more alcohol in 2012–2013 than they did in 2001–2002, according to the most recent National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). NESARC–III is a cross-sectional survey sponsored, designed, and directed by NIAAA and is the largest study ever conducted on the co-occurrence of alcohol use, drug use, and related psychiatric conditions. To assess how drinking patterns...

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