Research

The NIAAA is the lead agency for U.S. research on the causes, consequences, prevention and treatment of alcohol use disorder and alcohol-related problems.

Laboratory of Neuroimaging

Contact Information

  • Lab: 1 (301) 402-0868

Overview of the Lab

LNI uses brain imaging (PET, MRI and simultaneous PET/MRI) to study the neurocircuitry that underlies the rewarding effects of drugs of abuse and of natural reinforcers and their disruption in diseases of addiction and obesity. For this purpose we study how reward circuits modulate executive function (self-control), interoception, and motivation in the normal human brain including an understanding of the role of brain dopamine signaling, functional brain network interactions and genetics. We evaluate the disruption of these interactions in substance use disorder and morbid obesity, which are disorders characterized by deficits in self-control and reward sensitivity. We also focus on methodological studies to advance the tools to study function of the human brain including development of PET radiotracers, which is focused on the development of ligands to map epigenetic processes, development of analytical tools to help analyze and understand the underlying physiology behind the dynamically complex patterns of brain networks.

Research Projects

We are looking for volunteers!

Our Research Protocols that are actively recruiting volunteers:

14-AA-0144 Reliability of The Human Brain Connectome

15-AA-0186 Development of Neuroimaging Methods to Assess the Neurobiology of Addiction

17-AA-0114 Brain Dopaminergic Signaling in Opioid Use Disorders (OUD)

17-AA-0178 Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

Research Protocols that are not recruiting:

14-AA-0187 Dopamine Rhythms in Health and Addiction

15-AA-0031 Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness 

16-AA-0059 Characterization of Brain Amyloid-beta (A-beta) Retention During Wakefulness And Following Emergence From Sleep In Healthy Subjects 

14-AA-0192 Brain Inflammation and Function in Alcoholism

17-AA-0152 Ketogenic Diet (KD) in Alcoholism

Lab Members

Selected Publications

  • Zhang R, Manza P, Volkow ND. Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9- to 11-year-old children. J Child Psychol Psychiatry. 2021 Jul 27. doi: 10.1111/jcpp.13495. Epub ahead of print.
  • Zhang R, Manza P, Tomasi D, Kim SW, Shokri-Kojori E, Demiral SB, Kroll DS, Feldman DE, McPherson KL, Biesecker CL, Wang GJ, Volkow ND. Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward. J Clin Invest. 2021 Jul 15:149722. doi: 10.1172/JCI149722. Epub ahead of print.
  • Tan Z, Li G, Zhang W, Wang J, Hu Y, Li H, Zhang L, Lv S, Jia Z, Li X, Han Y, Cui G, Manza P, Volkow ND, Nie Y, Ji G, Wang GJ, Zhang Y. Obese Individuals Show Disrupted Dynamic Functional Connectivity between Basal Ganglia and Salience Networks. Cereb Cortex. 2021 Jul 8:bhab190. doi: 10.1093/cercor/bhab190. Epub ahead of print.
  • McPherson KL, Tomasi DG, Wang GJ, Manza P, Volkow ND. Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women. Front Psychiatry. 2021 May 13;12:643193. doi: 10.3389/fpsyt.2021.643193.
  • Tomasi D, Volkow ND. Associations of family income with cognition and brain structure in USA children: prevention implications. Mol Psychiatry. 2021 May 14. doi: 10.1038/s41380-021-01130-0. Epub ahead of print.
  • Wiers CE, Vendruscolo LF, van der Veen JW, Manza P, Shokri-Kojori E, Kroll DS, Feldman DE, McPherson KL, Biesecker CL, Zhang R, Herman K, Elvig SK, Vendruscolo JCM, Turner SA, Yang S, Schwandt M, Tomasi D, Cervenka MC, Fink-Jensen A, Benveniste H, Diazgranados N, Wang GJ, Koob GF, Volkow ND. Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents. Sci Adv. 2021 Apr 9;7(15):eabf6780. doi: 10.1126/sciadv.abf6780. Print 2021 Apr.
  • Tomasi D, Wiers CE, Manza P, Shokri-Kojori E, Michele-Vera Y, Zhang R, Kroll D, Feldman D, McPherson K, Biesecker C, Schwandt M, Diazgranados N, Koob GF, Wang GJ, Volkow ND. Accelerated Aging of the Amygdala in Alcohol Use Disorders: Relevance to the Dark Side of Addiction. Cereb Cortex. 2021 Jun 10;31(7):3254-3265. doi: 10.1093/cercor/bhab006. Online ahead of print.
  • Agarwal K, Manza P, Leggio L, Livinski AA, Volkow ND, Joseph PV. Sensory cue reactivity: Sensitization in alcohol use disorder and obesity. Neurosci Biobehav 2021 Feb 12;124:326-357. doi: 10.1016/j.neubiorev.2021.02.014. Online ahead of print.
  • Wiers CE, Zhao J, Manza P, Murani K, Ramirez V, Zehra A, Freeman C, Yuan K, Wang GJ, Demiral SB, Childress AR, Tomasi D, Volkow ND. Conscious and unconscious brain responses to food and cocaine cues. Brain Imaging Behav. 2021 Feb;15(1):311-319.
  • Hu Y, Ji G, Li G, Manza P, Zhang W, Wang J, Lv G, He Y, Zhang Z, Yuan K, von Deneen KM, Chen A, Cui G, Wang H, Wiers CE, Volkow ND, Nie Y, Zhang Y, Wang GJ. Brain connectivity, and hormonal and behavioral correlates of sustained weight loss in obese patients after laparoscopic sleeve gastrectomy. Cereb Cortex. 2021 Jan 5;31(2):1284-1295. doi: 10.1093/cercor/bhaa294.
  • Zhang W, Ji G, Manza P, Li G, Hu Y, Wang J, Lv G, He Y, von Deneen KM, Han Y, Cui G, Tomasi D, Volkow ND, Nie Y, Wang GJ, Zhang Y. Connectome-Based Prediction of Optimal Weight Loss Six Months After Bariatric Surgery. Cereb Cortex. 2021 Mar 31;31(5):2561-2573. doi: 10.1093/cercor/bhaa374.Online ahead of print.
  • Volkow ND, Gordon JA, Freund MP. The Healthy Brain and Child Development Study-Shedding Light on Opioid Exposure, COVID-19, and Health Disparities. JAMA Psychiatry. 2021 May 1;78(5):471-472. doi: 10.1001/jamapsychiatry.2020.3803. Online ahead of print.
  • Benveniste H, Lee H, Ozturk B, Chen X, Koundal S, Vaska P, Tannenbaum A, Volkow ND. Glymphatic cerebrospinal fluid and solute transport quantified by MRI and PET imaging. Neuroscience. 2020 Nov 26:S0306-4522(20)30730-2. doi: 10.1016/ j.neuroscience.2020.11.014. Online ahead of print.
  • De Carvalho LM, Wiers CE, Sun H, Wang GJ, Volkow ND. Increased transcription of TSPO, HDAC2, and HDAC6 in the amygdala of males with alcohol use disorder. Brain Behav. 2021 Feb;11(2):e01961. doi: 10.1002/brb3.1961. Epub 2020 Nov 20.
  • Wiers CE, Cunningham SI, Tomasi DG, Ernst T, Chang L, Shokri-Kojori E, Wang GJ, Volkow ND. Elevated thalamic glutamate levels and reduced water diffusivity in alcohol use disorder: Association with impulsivity. Psychiatry Res Neuroimaging. 2020 Sep 10;305:111185. doi: 10.1016/j.pscychresns.2020.111185. Online ahead of print.
  • Kroll DS, Feldman DE, Wang SA, Zhang R, Manza P, Wiers CE, Volkow ND, Wang GJ. The associations of comorbid substance use disorders and psychiatric conditions with adolescent brain structure and function: A review. J Neurol Sci. 2020 Nov 15;418:117099. doi: 10.1016/j.jns.2020.117099. Epub 2020 Aug 19.
  • Manza, P, Wiers, CE, Shokri-Kojori, E, Kroll, D, Feldman, D, Schwandt, M, Wang, GJ, Tomasi, D & Volkow, ND. Brain Network Segregation and Glucose Energy Utilization: Relevance for Age-Related Differences in Cognitive Function. Cerebral Cortex (2020).
  • Kroll, DS, Feldman, DE, Biesecker, CL, McPherson, KL, Manza, P, Joseph, PV, . & Wang, GJ Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission. Nutrients, 1942. (2020).
  • Feldman, DE, McPherson, KL, Biesecker, CL, Wiers, CE, Manza, P, Volkow, ND, & Wang, GJ. Neuroimaging of inflammation in alcohol use disorder: a review. Information Sciences, (2020).
  • Manza, P, Yuan, K, Shokri-Kojori, E, Tomasi, D & Volkow, ND. Brain structural changes in cannabis dependence: association with MAGL. Molecular Psychiatry. (2019)
  • Burns JA, Kroll DS, Feldman DE, Kure Liu C, Manza P, Wiers CE, Volkow ND, Wang GJ. Molecular imaging of opioid and dopamine systems: insights into the pharmacogenetics of opioid use disorders. Front. Psychiatry. (2019)
  • Wiers CE, Martins de Carvalho L, Hodgkinson CA, Schwandt M, Kim SW, Diazgranados N, Wang GJ, Goldman D, Volkow ND. TSPO polymorphism in individuals with alcohol use disorder: Association with cholesterol levels and withdrawal severity. Addiction Biology. (2019)
  • Tomasi DG, Wiers CE, Shokri-Kojori E, Zehra A, Ramirez V, Freeman C, Burns J, Kure Liu C, Manza P, Kim SW, Wang GJ, Volkow ND. Association between reduced brain glucose metabolism and Cortical Thickness in Alcoholics: Evidence of Neurotoxicity. Int J Neuropsychopharacol. (2019) Pubmed
  • Zhang R, Volkow ND. Brain default-mode network dysfunction in addiction. Neuroimage (2019). Pubmed
  • Manza P, Shokri-Kojori E, Volkow ND. Reduced segregation between cognitive and emotional processes in cannabis dependence Cereb. Cortex. (2019). Pubmed
  • Martins de Carvalho L, Wiers CE, Manza P, Sun H, Schwandt M, Wang GJ, Grassi-Oliveira R, Godard ALB, Volkow ND. Effect of alcohol use disorder on cellular aging. Psychopharmacology (2019). Pubmed
  • Kure Liu C, Joseph PV, Feldman DE, Kroll DS, Burns JA, Manza P, Volkow ND, Wang GJ. Brain Imaging of Taste Perception in Obesity: a Review. Current Nutrition Reports (2019). Pubmed
  • Tyler RE, Kim SW, Guo M, Jang YJ, Damadzic R, Stodden T, Vendruscolo LF, Koob GF, Wang GJ, Wiers CE, Volkow ND. Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding. Eur J Neurosci. (2019). Pubmed
  • Wang GJ, Wiers CE, Shumay E, Tomasi D, Yuan K, Wong CT, Logan J, Fowler JS, Volkow ND. Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder. Translational psychiatry (2019) Pubmed
  • Shokri-Kojori E, Tomasi D, Alipanahi B, Wiers CE, Wang GJ, Volkow ND. Correspondence between cerebral glucose metabolism and BOLD reveals relative power and cost in human brain. (2019) Pubmed
  • Li G, Ji G, Hu Y, Liu L, Jin Q, Zhang W, Liu L, Wang Y, Zhao J, von Deneen KM, Chen A, Cui G, Han Y, Wang H, Zhao Q, Wu K, Wiers CE, Tomasi D, Leggio L, Volkow ND, Nie Y, Zhang Y, Wang GJ. Reduced plasma ghrelin concentrations are associated with decreased brain reactivity to food cues after laparoscopic sleeve gastrectomy. Psychoneuroendocrinology (2019). Pubmed
  • Tomasi D, Volkow ND. Reduced Local and Increased Long-Range Functional Connectivity of the Thalamus in Autism Spectrum Disorder. Cereb Cortex (2019). Pubmed
  • Demiral ŞB, Tomasi D, Sarlls J, Lee H, Wiers CE, Zehra A, Srivastava T, Ke K, Shokri-Kojori E, Freeman CR, Lindgren E, Ramirez V, Miller G, Bandettini P, Horovitz S, Wang GJ, Benveniste H, Volkow ND. Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system? Neuroimage (2019). Pubmed
  • Zehra A, Lindgren E, Wiers CE, Freeman C, Miller G, Ramirez V, Shokri-Kojori E, Wang GJ, Talagala L, Tomasi D, Volkow ND. Neural correlates of visual attention in alcohol use disorder. Drug Alcohol Depend (2019). Pubmed
  • Shokri-Kojori, E, Dardo T, Volkow ND. An Autonomic Network: Synchrony Between Slow Rhythms of Pulse and Brain Resting State Is Associated with Personality and Emotions. Cerebral Cortex (2018). Pubmed
  • Li G, Ji G, Hu Y, Xu M, Jin Q, Liu L, von Deneen KM, Zhao J, Chen A, Cui G, Wang H, Zhao Q, Wu K, Shokri-Kojori E, Tomasi D, Volkow ND, Nie Y, Zhang Y, Wang GJ. Bariatric surgery in obese patients reduced resting connectivity of brain regions involved with self-referential processing. Hum Brain Mapp. (2018). Pubmed
  • Zehra A, Burns J, Liu CK, Manza P, Wiers CE, Volkow ND, Wang GJ. Cannabis Addiction and the Brain: a Review. J Neuroimmune Pharmacol. (2018). Pubmed
  • Wang R, Li M, Zhao M, Yu D, Hu Y, Wiers CE, Wang GJ, Volkow ND, Yuan K. Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway. Brain Imaging Behav. (2018). Pubmed
  • Wiers CE, Lohoff FW, Lee J, Muench C, Freeman C, Zehra A, Marenco S, Lipska BK, Auluck PK, Feng N, Sun H, Goldman D, Swanson JM, Wang GJ, Volkow ND. Methylation of the dopamine transporter gene in blood is associated with striatal dopamine transporter availability in ADHD: a preliminary study. Eur J Neurosci. (2018). Pubmed
  • Tomasi D, Volkow ND. Association Between Brain Activation and Functional Connectivity. Cereb Cortex. (2018). Pubmed
  • Freeman CR, Wiers CE, Sloan ME, Zehra A, Ramirez V, Wang GJ, Volkow ND. Emotion Recognition Biases in Alcohol Use Disorder. Alcohl Clin Exp Res. (2018). Pubmed
  • Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, Wang GJ, Volkow ND, Hurd YL. Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity. Mol Psychiatry. (2018). Pubmed
  • Gu X, Chen W, Volkow ND, Koretsky AP, Du C, Pan Y. Synchronized Astrocytic Ca2+ Responses in Neurovascular Coupling during Somatosensory Stimulation and for the Resting State. Cell Rep. (2018). Pubmed
  • Liu, L, Ji, G, Li, G, Hu, Y, Jin, Q, Hu, C, Zhao J, Meng Q, von Deneen KM, Chen A, Cui G, Wang H, Zhao Q, Wu K, Tian J, Shokri-Kojori E, Tomasi D, Volkow ND, Nie Y, Zhang Y, Wang GJ. Structural changes in brain regions involved in executive-control and self-referential processing after sleeve gastrectomy in obese patients. Brain Imaging and Behavior (2018). Pubmed
  • Zhang Y, Ji G, Li G, Hu Y, Liu L, Jin Q, Meng Q, Zhao J, Yuan K, Liu J, von Deneen KM, Chen A, Cui G, Wang H, Zhao Q, Wu K, Tian J, Manza P, Tomasi DG, Volkow ND, Nie Y, Wang G-J. Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus. Int J Obese (2018). Pubmed
  • Park K, Chen W, Volkow ND, Allen CP, Pan Y, Du C. Hemodynamic and neuronal responses to cocaine differ in awake versus anesthetized animals: Optical brain imaging study. Neuroimage (2018). Pubmed
  • Demiral ŞB, Tomasi D, Wiers CE, Manza P, Shokri-Kojori E, Studentsova Y, Wang GJ, Volkow ND. Methylphenidate's effects on thalamic metabolism and functional connectivity in cannabis abusers and healthy controls. Neuropsychopharmacology (2018). Pubmed
  • Guo M, Gao ZG, Tyler R, Stodden T, Li Y, Ramsey J, Zhao WJ, Wang GJ, Wiers CE, Fowler JS, Rice KC, Jacobson KA, Kim SW, Volkow ND. Preclinical Evaluation of the First Adenosine A1 Receptor Partial Agonist Radioligand for Positron Emission Tomography Imaging. J Med Chem. (2018). Pubmed
  • Wang GJ, Zhao J, Tomasi D, Shokri-Kojori E, Wang R, Wiers CE, Caparelli E, Volkow ND. Effect of combined naltrexone and bupropion therapy on the brain’s functional connectivity. Int J Obes (2018). Pubmed
  • Yuan K, Zhao M, Yu D, Manza P, Volkow ND, Wang GJ, Tian J. Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers. Neuropsychopharmacology (2018). Pubmed
  • Du C, Volkow ND, You J, Park K, Allen CP, Koob GF, Pan Y. Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents. Mol Psychiatry (2018). Pubmed
  • Meng Q, Han Y, Ji G, Li G, Hu Y, Liu L, Jin Q, von Deneen KM, Zhao J, Cui G, Wang H, Tomasi D, Volkow ND, Liu J, Nie Y, Zhang Y, Wang GJ. Disrupted topological organization of the frontal-mesolimbic network in obese patients. Brain Imaging Behav. (2018). Pubmed
  • Wiers CE, Towb PC, Hodgkinson CA, Shen PH, Freeman C, Miller G, Lindgren E, Shokri-Kojori E, Demiral ŞB, Kim SW, Tomasi D, Sun H, Wang GJ, Goldman D, Volkow ND. Association of genetic ancestry with striatal dopamine D2/D3 receptor availability. Molecular Psychiatry. 2018 Aug;23(8):1711-1716. Pubmed
  • Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral ŞB, Diazgranados N, Park L, Liow JS, Pike V, Morse C, Vendruscolo LF, Innis RB, Koob GF, Tomasi D, Wang GJ, Volkow ND. Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C] PBR28 studies in humans and rodents. Neuropsychopharmacology. 2018 Aug;43(9):1832-1839. Pubmed
  • Freeman CR, Zehra A, Ramirez V, Wiers CE, Volkow ND, Wang GJ. Impact of sugar on the body, brain, and behavior. Front Biosci (Landmark Ed). 2018 Jun 1;23:2255-2266. Pubmed
  • Manza P, Schwartz G, Masson M, Kann S, Volkow ND, Li CR, Leung HC. Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease. Neurobiol Aging. 2018 Jun;66:12-22. Pubmed
  • Ramirez, V, Shokri-Kojori, E, Cabrera, EA, Wiers, CE, Merikangas, K, Tomasi, D, Wang, GJ Volkow, ND Physical activity measured with wrist and ankle accelerometers: Age, gender, and BMI effects. PLoS One. 2018 Apr 27;13(4):e0195996. Pubmed
  • Shokri-Kojori E, Wang GJ, Wiers CE, Demiral SB, Guo M, Kim SW, Lindgren E, Ramirez V, Zehra A, Freeman C, Miller G, Manza P, Srivastava T, De Santi S, Tomasi D, Benveniste H, Volkow ND. β-Amyloid accumulation in the human brain after one night of sleep deprivation. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4483-4488. Pubmed
  • Chen W, Volkow ND, Li J, Pan Y, Du C. Cocaine Decreases Spontaneous Neuronal Activity and Increases Low-Frequency Neuronal and Hemodynamic Cortical Oscillations. Cereb Cortex. 2018 Apr 18.Pubmed
  • Allen CP, Park K, Li A, Volkow ND, Koob GF, Pan Y, Hu XT, Du C. Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats. Addict Biol. 2018 Mar 5. Pubmed
  • Manza P, Tomasi D, Volkow ND. Subcortical local functional hyperconnectivity in cannabis dependence. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2018 Mar;3(3):285-293. Pubmed
  • Kaczocha M, Azim S, Nicholson J, Rebecchi MJ, Lu Y, Feng T, Romeiser JL, Reinsel R, Rizwan S, Shodhan S, Volkow ND, Benveniste H. Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial. BMC Anesthesiol. 2018 Feb 27;18(1):27. Pubmed
  • Dencker D, Molander A, Thomsen M, Schlumberger C, Wortwein G, Weikop P, Benveniste H, Volkow ND, Fink-Jensen A. Ketogenic Diet Suppresses Alcohol Withdrawal Syndrome in Rats. Alcohol Clin Exp Res. 2018 Feb;42(2):270-277. Pubmed
  • Gu X, Chen W, You J, Koretsky AP, Volkow ND, Pan Y, Du C. Long-term optical imaging of neurovascular coupling in mouse cortex using GCaMP6f and intrinsic hemodynamic signals. Neuroimage. 2018 Jan 15;165:251-264. Pubmed
  • Lindgren E, Gray K, Miller G, Tyler R, Wiers CE, Volkow ND, Wang GJ. Food Addiction: A common neurobiological mechanism with Drug Abuse. Front Biosci (Landmark Ed). 2018 Jan 1;23:811-836. Pubmed
  • Zhao J, Tomasi D, Wiers CE, Shokri-Kojori E, Demiral SB, Zhang Y, Volkow ND, Wang GJ. Correlation between traits of emotion-based impulsivity and intrinsic default-mode network activity. Neural Plasticity. 2017;2017:9297621 Pubmed
  • Wiers CE, Cabrera EA, Tomasi D, Wong CT, Demiral ŞB, Kim SW, Wang GJ, Volkow ND. Striatal Dopamine D2/D3 Receptor Availability Varies Across Smoking Status. Neuropsychopharmacology. 2017 Nov;42(12):2325-2332. Pubmed
  • Michaelides M, Miller ML, DiNieri JA, Gomez JL, Schwartz E, Egervari G, Wang GJ, Mobbs CV, Volkow ND, Hurd YL. Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic-Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement. Neuropsychopharmacology. 2017 Nov;42(12):2365-2376. Pubmed
  • Wiers CE, Cabrera E, Tomasi D, Demiral ŞB, Kim SW, Wong CT, Wang GJ, Volkow ND. Methylphenidate-induced dopamine release varies across smoking status. 2017 Nov;42(12):2325-2332. Pubmed
  • Benveniste H, Lee H, Volkow ND. The Glymphatic Pathway: Waste Removal from the CNS via Cerebrospinal Fluid Transport. Neuroscientist. 2017 Oct;23(5):454-465. Pubmed
  • Tomasi DG, Shokri-Kojori E, Volkow ND. Temporal Evolution of Brain Functional Connectivity Metrics: Could 7 Min of Rest be Enough? Cereb Cortex. 2017 Aug 1;27(8):4153-4165. PubMed
  • Shokri-Kojori E, Tomasi D, Wiers CE, Wang GJ, Volkow ND. Linking brain connectivity and behavior after acute and chronic alcohol exposure. Mol Psychiatry, 2017; 22(8):1079. Pubmed
  • Shokri-Kojori E, Tomasi D, Wiers CE, Wang GJ, Volkow ND. Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers. 2017 Aug;22(8):1185-1195. Pubmed
  • Volkow ND, Wiers CE, Shokri-Kojori E, Tomasi D, Wang GJ, Baler R. Neurochemical and metabolic effects of acute and chronic alcohol in the human brain: studies with positron emission tomography. Neuropharmacology. 2017; Aug 1;122:175-188. Pubmed
  • Shumay E, Wiers CE, Shokri-Kojori E, Kim SW, Hodgkinson CA, Sun H, Tomasi D, Wong CT, Weinberger DR, Wang, GJ, Fowler JS, Volkow ND. New repeat polymorphism in the AKT1 gene predicts striatal dopamine D2/D3 receptor availability and stimulant-induced dopamine release in the healthy human brain. J Neurosci. 2017; May 10;37(19):4982-4991. Pubmed
  • You J, Volkow ND, Park K, Zhang Q, Clare K, Du C, Pan Y. Cerebrovascular adaptations to cocaine-induced transient ischemic attacks in the rodent brain. JCI Insight. 2017 Mar;2(5):e90809. Pubmed
  • Thanos PK, Kim R, Delis F, Rocco MJ, Cho J, Volkow ND. Effects of chronic methamphetamine on psychomotor and cognitive functions and dopamine signaling in the brain. Behav Brain Res. 2017 Mar;320:282-290. Pubmed
  • Tomasi DG, Shokri-Kojori E, Volkow ND. Brain Network Dynamics Adhere to a Power Law. Front Neurosci. 2017 Feb 14;11:72. Pubmed
  • Cunningham SI, Tomasi D, Volkow ND. Structural and functional connectivity of the precuneus and thalamus to the default mode network. Hum Brain Mapp. 2017 Feb;38(2):938-956. Pubmed
  • Tomasi D, Shokri-Kojori E, Wiers CE, Kim SW, Demiral ŞB., Cabrera EA, Lindgren E, Miller G, Wang GJ, Volkow ND. Dynamic brain glucose metabolism identifies anti-correlated networks at rest. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17708692. Pubmed
  • Wiers CE, Shokri-Kojori E, Wong CT, Abi-Dargham A, Demiral ŞB, Tomasi D, Wang GJ, Volkow ND. Cannabis Abusers Show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males. Neuropsychopharmacology. 2016;41(10):2596-605. PubMed
  • Chen W, Liu P, Volkow ND, Pan Y, Du C. Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity. Mol Psychiatry. 2016 Oct;21(10):1408-16. Pubmed
  • Cabrera EA, Wiers CE, Lindgren E, Miller G, Volkow ND, Wang GJ. Neuroimaging the Effectiveness of Substance Use Disorder Treatments. J Neuroimmune Pharmacol. 2016;11(3):408-33. PubMed
  • Roux A, Jackson SN, Muller L, Barbacci D, O'Rourke J, Thanos PK, Volkow ND, Balaban C, Schultz JA, Woods AS. Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry. ACS Chem Neurosci. 2016 Aug 17;7(8):1148-56. PubMed
  • Zhang Y, Ji G, Xu M, Cai W, Zhu Q, Qian L, Zhang YE, Yuan K, Liu J, Li Q, Cui G, Wang H, Zhao Q, Wu K, Fan D, Gold MS, Tian J, Tomasi D, Liu Y, Nie Y, Wang GJ. Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery. Int J Obes (Lond). 2016 Jun 21. PubMed
  • Thanos PK, Kim R, Delis F, Ananth M, Chachati G, Rocco MJ, Masad I, Muniz JA, Grant SC, Gold MS, Cadet JL, Volkow ND. Chronic Methamphetamine Effects on Brain Structure and Function in Rats. PLoS One. 2016 Jun 8;11(6):e0155457. PubMed
  • Tomasi D, Wang GJ, Volkow ND. Association between striatal dopamine D2/D3 receptors and brain activation during visual attention: effects of sleep deprivation. Transl Psychiatry. 2016 May 31;6(5):e828. PubMed
  • Tomasi D, Shokri-Kojori E, Volkow ND. Temporal Changes in Local Functional Connectivity Density Reflect the Temporal Variability of the Amplitude of Low Frequency Fluctuations in Gray Matter. PLoS One. 2016 Apr 26;11(4):e0154407 PubMed
  • Thanos PK, Malave L, Delis F, Mangine P, Kane K, Grunseich A, Vitale M, Greengard P, Volkow ND. Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned. Synapse. 2016;70(7):293-301. PubMed
  • Belcher AM, Yen CC, Notardonato L, Ross TJ, Volkow ND, Yang Y, Stein EA, Silva AC, Tomasi D. Functional Connectivity Hubs and Networks in the Awake Marmoset Brain. Front Integr Neurosci. 2016;10:9. PubMed
  • Zhang Y, Li Q, Wen X, Cai W, Li G, Tian J, Zhang YE, Liu J, Yuan K, Zhao J, Wang W, Zhou Z, Ding M, Gold MS, Liu Y, Wang GJ. Granger causality reveals a dominant role of memory circuit in chronic opioid dependence. Addict Biol. 2016 Mar 14. PubMed
  • Wiers CE, Shumay E, Cabrera E, Shokri-Kojori E, Gladwin TE, Skarda E, Cunningham SI, Kim SW, Wong TC, Tomasi D, Wang GJ, Volkow ND. Reduced sleep duration mediates decreases in striatal D2/D3 receptor availability in cocaine abusers. Transl Psychiatry. 2016 Mar 8;6:e752. PubMed
  • Wiers CE, Shokri-Kojori E, Cabrera E, Cunningham S, Wong C, Tomasi D, Wang GJ, Volkow ND. Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers. Neurosci Lett. 2016 Mar 23;617:27-31. PubMed
  • Zhang Q, You J, Volkow ND, Choi J, Yin W, Wang W, Pan Y, Du C. Chronic cocaine disrupts neurovascular networks and cerebral function: optical imaging studies in rodents. J Biomed Opt. 2016 Feb;21(2):26006.  PubMed
  • Wiers CE, Cabrera E, Skarda E, Volkow ND, Wang GJ. PET imaging for addiction medicine: From neural mechanisms to clinical considerations. Prog Brain Res. 2016;224:175-201. PubMed
  • Tomasi D, Shokri-Kojori E, Volkow ND. High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability. Cereb Cortex. 2016;26(7):3249-59. PubMed
  • Volkow N.D., Wang G.J., Smith L., Fowler J.S., Telang F., Logan J., Tomasi D. Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release. Neuroimage. 2015;121:20-8. PubMed
  • Tomasi D., Wang G.J., Studentsova Y., Volkow N.D. Dissecting Neural Responses to Temporal Prediction, Attention, and Memory: Effects of Reward Learning and Interoception on Time Perception. Cereb Cortex. 2015 Oct;25(10):3856-67. PubMed
  • Wiers C.E., Shumay E., Volkow N.D., Frieling H., Kotsiari A., Lindenmeyer J., Walter H., Bermpohl F. Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism. Transl Psychiatry. 2015;5:e648. PubMed
  • Tomasi D., Wang G.J., Volkow N.D. Balanced modulation of striatal activation from D2 /D3 receptors in caudate and ventral striatum: Disruption in cannabis abusers. Hum Brain Mapp. 2015;36(8):3154-66. PubMed  
  • Bonaventura J, Navarro G, Casadó-Anguera V, Azdad K, Rea W, Moreno E, Brugarolas M, Mallol J, Canela EI, Lluís C, Cortés A, Volkow ND, Schiffmann SN, Ferré S, Casadó V. Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer. Proc Natl Acad Sci U S A. 2015 Jul;112(27):E3609-18. Pubmed
  • Thanos PK, Michaelides M, Subrize M, Miller ML, Bellezza R, Cooney RN, Leggio L, Wang GJ, Rogers AM, Volkow ND, Hajnal A. Roux-en-Y Gastric Bypass Alters Brain Activity in Regions that Underlie Reward and Taste Perception. PLoS One. 2015 Jun;10(6):e0125570. Pubmed
  • Volkow N.D., Baler R.D. NOW vs LATER brain circuits: implications for obesity and addiction. Trends Neurosci. 2015 Jun;38(6):345-52. PubMed
  • Delis F, Rombola C, Bellezza R, Rosko L, Grandy DK, Volkow ND, Thanos PK. Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters. Front Behav Neurosci. 2015 May;9:118. Pubmed
  • Ferré S., Bonaventura J., Tomasi D., Navarro G., Moreno E., Cortés A., Lluís C., Casadó V., Volkow N.D. Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer. Neuropharmacology 2015;104:154-60. PubMed
  • Kravitz A.V., Tomasi D., LeBlanc K.H., Baler R., Volkow N.D., Bonci A., Ferré S. Cortico-striatal circuits: Novel therapeutic targets for substance use disorders. Brain Res. 2015; 1628(Pt A):186-98. PubMed
  • Volkow N.D., Wang G.J., Logan J., Alexoff D., Fowler J.S., Thanos P.K., Wong C., Casado V., Ferre S., Tomasi D. Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Transl Psychiatry. 2015 Apr 14;5:e549. PubMed
  • Fowler J.S., Logan J., Shumay E., Alia-Klein N., Wang G.J., Volkow N.D. Monoamine oxidase: radiotracer chemistry and human studies. J Labelled Comp Radiopharm. 2015 Mar;58(3):51-64. PubMed
  • Biegon A., Alexoff D., Kim S.W., Logan J, Pareto D, Schlyer D, Wang GJ, Fowler J. Aromatase Imaging with [N-methyl-C-11]vorozole PET in Healthy Men and Women. J Nucl Med. 2015; 56(4):580-5. PubMed
  • Volkow N.D., Wang G.J., Shokri Kojori E., Fowler J.S., Benveniste H., Tomasi D. Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases. J Neurosci. 2015 Feb 18;35(7):3248-55. PubMed
  • Fowler JS, Logan J, Volkow ND, Shumay E, McCall-Perez F, Jayne M, Wang GJ, Alexoff DL, Apelskog-Torres K, Hubbard B, Carter P, King P, Fahn S, Gilmor M, Telang F, Shea C, Xu Y, Muench L. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain. Neuropsychopharmacology. 2015 Feb;40(3):650-7. PubMed
  • Azim S, Nicholson J, Rebecchi MJ, Galbavy W, Feng T, Reinsel R, Volkow ND, Benveniste H, Kaczocha M. Endocannabinoids and acute pain after total knee arthroplasty. Pain. 2015 Feb;156(2):341-347. Pubmed
  • Tomasi D., Wang G.J., Wang R., Caparelli E.C., Logan J., Volkow N.D. Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: association to striatal D2/D3 receptors. Hum Brain Mapp. 2015 Jan;36(1):120-36. PubMed
  • Vanicek T, Spies M, Rami-Mark C, Savli M, Höflich A, Kranz GS, Hahn A, Kutzelnigg A, Traub-Weidinger T, Mitterhauser M, Wadsak W, Hacker M, Volkow ND, Kasper S, Lanzenberger R. The norepinephrine transporter in attention-deficit/hyperactivity disorder investigated with positron emission tomography. JAMA Psychiatry. 2014 Dec;71(12):1340-1349. Pubmed
  • Pan Y, You J, Volkow ND, Park K, Du C. Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo. Neuroimage. 2014 Dec;103:492-501. Pubmed
  • Du C, Volkow ND, Koretsky AP, Pan Y. Low-frequency calcium oscillations accompany deoxyhemoglobin oscillations in rat somatosensory cortex. Proc Natl Acad Sci U S A. 2014 Oct;111(43):E4677-86. Pubmed
  • Tomasi D., Wang R., Wang G.J., Volkow N.D. Functional connectivity and brain activation: a synergistic approach. Cereb Cortex. 2014 Oct;24(10):2619-29. PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Logan J., Alexoff D.L., Jayne M., Fowler J.S., Wong C., Yin P., Du C. Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. Mol Psychiatry. 2014 Sep;19(9):1037-43. PubMed
  • Alia-Klein N., Wang G.J., Preston-Campbell R.N., Moeller S.J., Parvaz M.A., Zhu W., Jayne M.C., Wong C., Tomasi D., Goldstein R.Z., Fowler J.S., Volkow N.D. Mu Opioid Receptor Binding Correlates with Nicotine Dependence and Reward in Smokers. Reactions to media violence: it's in the brain of the beholder. PLoS One. 2014 Sep 10;9(9):e107260. PubMed
  • Kim S.W., Fowler J.S., Skolnick P., Muench L., Kang Y., Shea C., Logan J., Kim D., Carter P., King P., Alexoff D., Volkow N.D. Therapeutic doses of buspirone block D3 receptors in the living primate brain. Int J Neuropsychopharmacol. 2014 Aug;17(8):1257-67. PubMed
  • Volkow N.D., Wang G.J., Telang F., Fowler J.S., Alexoff D., Logan J., Jayne M., Wong C., Tomasi D. Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3149-56. PubMed
  • Seo Y.J., Kang Y., Muench L., Reid A., Caesar S., Jean L., Wagner F., Holson E., Haggarty S.J., Weiss P., King P., Carter P., Volkow N.D., Fowler J.S., Hooker J.M., Kim S.W. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. ACS Chem Neurosci. 2014 Jul 16;5(7):588-96. PubMed
  • Moeller S.J., Parvaz M.A., Shumay E., Wu S., Beebe-Wang N., Konova A.B., Misyrlis M., Alia-Klein N., Goldstein R.Z. Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology. Drug Alcohol Depend. 2014 Jul 1;140:17-24. PubMed
  • Wang G.J., Tomasi D., Convit A., Logan J., Wong C.T., Shumay E., Fowler J.S., Volkow N.D. BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake. PLoS One. 2014 Jul 7;9(7):e101585. PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Studentsova Y., Margus B., Crawford T.O. Brain glucose metabolism in adults with ataxia-telangiectasia and their asymptomatic relatives. Brain. 2014 Jun;137(Pt 6):1753-61. PubMed
  • Wang G.J., Tomasi D., Volkow N.D., Wang R., Telang F., Caparelli E.C., Dunayevich E. Effect of combined naltrexone and bupropion therapy on the brain's reactivity to food cues. Int J Obes (Lond). 2014 May;38(5):682-8. PubMed
  • Logan J., Kim S.W., Pareto D., Telang F., Wang G.J., Fowler J.S., Biegon A. Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography. Mol Imaging. 2014 May;13(3):1-12. PubMed
  • Tomasi D., Volkow N.D. Mapping small-world properties through development in the human brain: disruption in schizophrenia. PLoS One. 2014 Apr 30;9(4):e96176. PubMed
  • Tomasi D., Volkow N.D. Functional connectivity of substantia nigra and ventral tegmental area: maturation during adolescence and effects of ADHD. Cereb Cortex. 2014 Apr;24(4):935-44. PubMed
  • Moeller S.J., Honorio J., Tomasi D., Parvaz M.A., Woicik P.A., Volkow N.D., Goldstein R.Z. Methylphenidate enhances executive function and optimizes prefrontal function in both health and cocaine addiction. Cereb Cortex. 2014 Mar;24(3):643-53. PubMed
  • Volkow N.D., Baler R.D. Addiction science: Uncovering neurobiological complexity. Neuropharmacology. 2014 Jan;76 Pt B:235-49. Review. PubMed
  • Moeller S.J., Konova A.B., Parvaz M.A., Tomasi D., Lane R.D., Fort C., Goldstein R.Z. Functional, structural, and emotional correlates of impaired insight in cocaine addiction. JAMA Psychiatry. 2014 Jan;71(1):61-70. PubMed
  • Polston JE, Pritchett CE, Tomasko JM, Rogers AM, Leggio L, Thanos PK, Volkow ND, Hajnal A. Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats. PLoS One. 2013 Dec 31;8(12):e83741. Pubmed
  • Seo Y.J., Muench L., Reid A., Chen J., Kang Y., Hooker J.M., Volkow N.D., Fowler J.S., Kim S.W. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6700-5. PubMed
  • Michaelides M., Anderson S.A., Ananth M., Smirnov D., Thanos P.K., Neumaier J.F., Wang G.J., Volkow N.D., Hurd Y.L. Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks. J Clin Invest. 2013 Dec;123(12):5342-50. PubMed
  • Anderson S.A., Michaelides M., Zarnegar P., Ren Y., Fagergren P., Thanos P.K., Wang G.J., Bannon M., Neumaier J.F., Keller E., Volkow N.D., Hurd Y.L. Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. J Clin Invest. 2013 Dec;123(12):5334-41. PubMed
  • Volkow N.D., Swanson J.M. Clinical practice: Adult attention deficit-hyperactivity disorder. N Engl J Med. 2013 Nov 14;369(20):1935-44. Review. PubMed
  • Park K, Volkow ND, Pan Y, Du C. Chronic cocaine dampens dopamine signaling during cocaine intoxication and unbalances D1 over D2 receptor signaling. J Neurosci. 2013 Oct;33(40):15827-36. Pubmed
  • Kim S.W., Hooker J.M., Otto N., Win K., Muench L., Shea C., Carter P., King P., Reid A.E., Volkow N.D., Fowler J.S. Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET. Nucl Med Biol. 2013 Oct;40(7):912-8. PubMed
  • Tomasi D., Wang G.J., Volkow N.D. Energetic cost of brain functional connectivity. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13642-7. PubMed
  • Volkow N.D., Wang G.J., Tomasi D., Baler R.D. Unbalanced neuronal circuits in addiction. Curr Opin Neurobiol. 2013 Aug;23(4):639-48. PubMed
  • Konova A.B., Moeller S.J., Tomasi D., Volkow N.D., Goldstein R.Z. Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction. JAMA Psychiatry. 2013 Aug;70(8):857-68. PubMed
  • Tomasi D., Volkow N.D. Brain activation and neurochemistry. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10888-9. PubMed
  • Volkow N.D., Baler R.D. Brain imaging biomarkers to predict relapse in alcohol addiction. JAMA Psychiatry. 2013 Jul;70(7):661-3. PubMed
  • Moeller S.J., Parvaz M.A., Shumay E., Beebe-Wang N., Konova A.B., Alia-Klein N., Volkow N.D., Goldstein R.Z. Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence. J Neurosci. 2013 Jun 12;33(24):10027-36. PubMed
  • Michaelides M., Miller M.L., Subrize M., Kim R., Robison L., Hurd Y.L., Wang G.J., Volkow N.D., Thanos P.K. Limbic activation to novel versus familiar food cues predicts food preference and alcohol intake. Brain Res. 2013 May 28;1512:37-44. PubMed
  • Volkow N.D, Tomasi D., Wang G.J., Telang F., Fowler J.S., Goldstein R.Z., Klein N., Wong C., Swanson J.M., Shumay E. Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism. PLoS One. 2013 May 22;8(5):e63492. PubMed
  • Wang G.J., Volkow N.D., Wigal T., Kollins S.H., Newcorn J.H., Telang F., Logan J., Jayne M., Wong C.T., Han H., Fowler J.S., Zhu W., Swanson J.M. Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder. PLoS One. 2013 May 15;8(5):e63023. PubMed
  • Volkow N.D., Wang G.J., Tomasi D., Baler R.D. The addictive dimensionality of obesity. Biol Psychiatry. 2013 May 1;73(9):811-8. Review. PubMed
  • Thanos P, Delis F, Rosko L, Volkow ND. Passive Response to Stress in Adolescent Female and Adult Male Mice after Intermittent Nicotine Exposure in Adolescence. J Addict Res Ther. 2013 Apr 23;Suppl 6:007. Pubmed
  • Thanos PK, Robison L, Nestler EJ, Kim R, Michaelides M, Lobo MK, Volkow ND. Mapping brain metabolic connectivity in awake rats with μPET and optogenetic stimulation. J Neurosci. 2013 Apr 10;33(15):6343-9. Pubmed
  • Thanos PK, Robison LS, Robinson JK, Michaelides M, Wang GJ, Volkow ND. Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cues. Synapse. 2013 Apr;67(4):171-8. Pubmed
  • Volkow N.D., Tomasi D., Wang G.J., Telang F., Fowler J.S., Logan J., Maynard L.J., Wong C.T. Predominance of D2 receptors in mediating dopamine's effects in brain metabolism: effects of alcoholism. J Neurosci. 2013 Mar 6;33(10):4527-35. PubMed
  • Thanos PK, Stamos J, Robison LS, Heyman G, Tucci A, Wang GJ, Robinson JK, Anderson BJ, Volkow ND. Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement. Behav Brain Res. 2013 Feb 15;239:8-14. Pubmed
  • Tomasi D., Volkow N.D. Striatocortical pathway dysfunction in addiction and obesity: differences and similarities. Crit Rev Biochem Mol Biol. 2013 Jan-Feb;48(1):1-19. Review. PubMed
  • Volkow N.D., Kim S.W., Wang G.J., Alexoff D., Logan J., Muench L., Shea C., Telang F., Fowler J.S., Wong C., Benveniste H., Tomasi D. Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain. Neuroimage. 2013 Jan 1;64:277-83. PubMed
  • Volkow N.D., Wang G.J., Tomasi D., Baler R.D. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013 Jan;14(1):2-18. Review. PubMed
  • Alzghoul L, Bortolato M, Delis F, Thanos PK, Darling RD, Godar SC, Zhang J, Grant S, Wang GJ, Simpson KL, Chen K, Volkow ND, Lin RC, Shih JC. Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice. Neuropharmacology. 2012 Dec;63(7):1208-17. Pubmed
  • Thanos PK, Subrize M, Delis F, Cooney RN, Culnan D, Sun M, Wang GJ, Volkow ND, Hajnal A. Gastric bypass increases ethanol and water consumption in diet-induced obese rats. Obes Surg. 2012 Dec;22(12):1884-92. Pubmed
  • Honorio J., Tomasi D., Goldstein R.Z., Leung H.C., Samaras D. Can a single brain region predict a disorder? IEEE Trans Med Imaging. 2012 Nov;31(11):2062-72. PubMed
  • Moeller S.J., Tomasi D., Woicik P.A., Maloney T., Alia-Klein N., Honorio J., Telang F., Wang G.J., Wang R., Sinha R., Carise D., Astone-Twerell J., Bolger J., Volkow N.D., Goldstein R.Z. Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choice. Addict Biol. 2012 Nov;17(6):1013-25. PubMed
  • Volkow N.D. Long-term safety of stimulant use for ADHD: findings from nonhuman primates. Neuropsychopharmacology. 2012 Nov;37(12):2551-2. PubMed
  • Moeller S.J., Tomasi D., Honorio J., Volkow N.D., Goldstein R.Z. Dopaminergic involvement during mental fatigue in health and cocaine addiction. Transl Psychiatry.  2012 Oct 23;2:e176. PubMed
  • Konova A.B., Moeller S.J., Tomasi D., Parvaz M.A., Alia-Klein N., Volkow N.D., Goldstein R.Z. Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction. Eur J Neurosci. 2012 Oct;36(7):2979-88. PubMed
  • Shumay E., Logan J., Volkow N.D., Fowler J.S. Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. Epigenetics. 2012 Oct;7(10):1151-60. PubMed
  • Konova A.B., Moeller S.J., Tomasi D., Parvaz M.A., Alia-Klein N., Volkow N.D., Goldstein R.Z. Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction. Eur J Neurosci. 2012 Oct;36(7):2979-88. PubMed
  • Wang G.J., Smith L., Volkow N.D., Telang F., Logan J., Tomasi D., Wong C.T., Hoffman W., Jayne M., Alia-Klein N., Thanos P., Fowler J.S. Decreased dopamine activity predicts relapse in methamphetamine abusers.  Mol Psychiatry. 2012 Sep;17(9):918-25. PubMed
  • Parvaz M.A., Maloney T., Moeller S.J., Woicik P.A., Alia-Klein N., Telang F., Wang G.J., Squires N.K.,Volkow N.D., Goldstein R.Z. Sensitivity to monetary reward is most severely compromised in recently abstaining cocaine addicted individuals: a cross-sectional ERP study. Psychiatry Res. 2012 Jul 30;203(1):75-82. PubMed
  • Parvaz M.A., Konova A.B., Tomasi D., Volkow N.D., Goldstein R.Z. Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward. J Cogn Neurosci. 2012 Jul;24(7):1560-70. PubMed
  • Tomasi D., Volkow N.D. Language network: segregation, laterality and connectivity. Mol Psychiatry. 2012 Jul;17(8):759.
  • Tomasi D., Volkow N.D. Resting functional connectivity of language networks: characterization and reproducibility. Mol Psychiatry. 2012 Jul;17(8):841-54. doi: 10.1038/mp.2011.177. PubMed 
  • Ren H., Du C., Park K., Volkow N.D., Pan Y. Quantitative imaging of red blood cell velocity invivo using optical coherence Doppler tomography. Applied physics letters. 2012 Jun;100(23): 233702-2337024. Pubmed
  • Komatsu DE, Thanos PK, Mary MN, Janda HA, John CM, Robison L, Ananth M, Swanson JM, Volkow ND, Hadjiargyrou M. Chronic exposure to methylphenidate impairs appendicular bone quality in young rats. Bone. 2012 Jun;50(6):1214-22. Pubmed
  • Tomasi D., Volkow N.D. Laterality patterns of brain functional connectivity: gender effects. Cereb Cortex. 2012 Jun;22(6):1455-62. doi: 10.1093/cercor/bhr230. PubMed
  • Volkow N.D., Muenke M. The genetics of addiction. Hum Genet. 2012 Jun;131(6):773-7. PubMed
  • Michaelides M., Thanos P.K., Volkow N.D., Wang G.J. Dopamine-related frontostriatal abnormalities in obesity and binge-eating disorder: emerging evidence for developmental psychopathology. Int Rev Psychiatry. 2012 Jun;24(3):211-8. Review. PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Telang F., Fowler J.S., Logan J., Benveniste H., Kim R., Thanos P.K., Ferré S. Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci. 2012 May 9;32(19):6711-7. PubMed
  • Tomasi D., Volkow N.D. Aging and functional brain networks. Mol Psychiatry. 2012 May;17(5):471, 549-58. PubMed
  • Delis F, Benveniste H, Xenos M, Grandy D, Wang GJ, Volkow ND, Thanos PK. Loss of dopamine D2 receptors induces atrophy in the temporal and parietal cortices and the caudal thalamus of ethanol-consuming mice. Alcohol Clin Exp Res. 2012 May;36(5):815-25. Pubmed
  • Tomasi D., Volkow N.D. Gender differences in brain functional connectivity density. Hum Brain Mapp. 2012 Apr;33(4):849-60. PubMed
  • Shumay E., Fowler J.S., Wang G.J., Logan J., Alia-Klein N., Goldstein R.Z., Maloney T., Wong C., Volkow N.D. Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. Transl Psychiatry. 2012 Mar 6;2:e86. PubMed
  • Tomasi D., Volkow N.D. Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2012 Mar 1;71(5):443-50. PubMed
  • Volkow N.D., Baler R.D. Neuroscience. To stop or not to stop? Science. 2012 Feb 3;335(6068):546-8. PubMed
  • Volkow N.D., Wang G.J., Tomasi D., Kollins S.H., Wigal T.L., Newcorn J.H., Telang F.W., Fowler J.S., Logan J., Wong C.T., Swanson J.M. Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. J Neurosci. 2012 Jan 18;32(3):841-9. PubMed
  • Michaelides M., Thanos P.K., Kim R., Cho J., Ananth M., Wang G.J., Volkow N.D. PET imaging predicts future body weight and cocaine preference. Neuroimage. 2012 Jan 16;59(2):1508-13. PubMed
  • Volkow N.D., Wang G.J., Fowler J.S., Tomasi D. Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol. 2012;52:321-36. Review. PubMed
  • Volkow N.D., Wang G.J., Fowler J.S., Tomasi D., Baler R. Food and drug reward: overlapping circuits in human obesity and addiction. Curr Top Behav Neurosci. 2012;11:1-24. Review. PubMed
  • Michaelides M., Thanos P.K., Volkow N.D., Wang G.J. Translational neuroimaging in drug addiction and obesity. ILAR J. 2012;53(1):59-68. Review. PubMed
  • Hajnal A, Zharikov A, Polston JE, Fields MR, Tomasko J, Rogers AM, Volkow ND, Thanos PK. Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism. PLoS One. 2012;7(11);e49121. Pubmed
  • Li Z, Xu Y, Warner D, Volkow ND. Alcohol ADME in primates studied with positron emission tomography. PLoS One. 2012;7(10):e46676. Pubmed

Other Lab Resources

Walter Reed Psychiatry Resident Research Rotation

Kyle Gray, MD, PGY3 Psychiatry Resident, starting 2015
Shram Shukla, MD, PGY2 Psychiatry Resident, starting 2016
 

Collaborators 

Helene D. Benveniste, MD, PhD, Professor of Anesthesiology, Yale University.

Linda Chang, MD, Professor of Diagnostic Radiology and Nuclear Medicine, University of Maryland

Thomas Ernst, PhD, Professor of Medicine, Professor of Diagnostic Radiology and Nuclear Medicine, University of Maryland

Anders Fink-Jensen, MD, Professor of Biological Psychiatry, Copenhagen University

Julia Cole Finkel, MD, Professor of Anesthesiology, Pediatrics and Critical Care Medicine
Children's National Medical Center and George Washington University

Joanna S. Fowler, PhD, Emeritus Chemist, Brookhaven National Laboratory

Samantha Irene Scott, PhD, Research Scientist, Vasoptic Medical Inc.

Yi Zhang, PhD, Professor, School of Life Science and Technology, Xidian University, China

Kai Yuan, PhD, School of Life Science and Technology, Xidian University, China

 

Alumni

Stephen Lee, MS
Graduate student, 2014-2015
Compliance officer, US consumer product safety commission
 
Emily Skarda, BS
Post-Baccalaureate IRTA Fellow, 2014-2015
Medical student, School of Medicine, University of Chicago
 
Samantha Irene Scott, PhD
Post-Doctoral IRTA Fellow, 2014-2015
Research Scientist, Vasoptic Medical Inc.
 
Elizabeth Cabrera, BS
Post-Baccalaureate IRTA Fellow, 2014-2016
Medical student, School of Medicine, University of Pittsburgh
 
Kristina Murani, BA
NIH Graduate Summer Opportunity to Advance Research, 2016
PhD student, American University
 
Elsa Lindgren, BS
Post-Baccalaureate IRTA Fellow, 2015-2017
Medical student, Geisel School of Medicine, Dartmouth College
 
Gregg Miller, BA
Post-Baccalaureate IRTA Fellow, 2015-2017
Medical student, School of Medicine, Tufts University
 
Ryan Tyler, BS
Post-Baccalaureate IRTA Fellow, 2015-2017
PhD Student, UNC-Chapel Hill
 
Jizheng Zhao, PhD
Special volunteer, 2016-2017
Lecturer, North West Agriculture and Forestry University, Yangling, Shaanxi, China
 
Parmalee C. Towb, PhD, MD
Walter Reed Psychiatry Resident Research Rotation, 2016-2017
Psychiatrist, US Marine
 
Chia-Hsiang Chan, MD
Special volunteer, 2017
Attending Psychiatrist, Taipei Medical University, Taiwan.
 
Hui-Hsien Hsiao, MD
Special volunteer, 2017
Attending Psychiatrist, National Jianan Psychiatric Center, Taiwan.
 
Kenny Ke, BS
Summer Student, 2017
Master Student, M.Eng. in Bioengineering, University of Maryland, College Park.
 
Katharina Ledermann, PhD
Special volunteer, 2017
Post-doctoral fellow, University of Fnbourg, Switzerland
 
Clara Freeman, BA
Post-Baccalaureate IRTA Fellow, 2016-2018
PhD student in Clinical Psychology, McGill University
 
Amna Zehra, BS
Post-Baccalaureate IRTA Fellow, 2016-2018
Medical student, School of Medicine, University of Maryland
 
Sukru Baris Demiral, Ph.D.
Post-Doctoral IRTA Fellow, 2016-2018
Research Scientist, Walter Reed research center
 
Jashua Park
Summer Student, 2017 and 2018
Undergraduate student, Johns Hopkins University
 
Sebastián Toxto, MD
Summer Masters Student, 2018
Psychiatry Resident, Universidad Nacional Autónoma de México
 
Lucy Qianyi Chen
Summer Student, 2018
Undergraduate student, Carnegie Mellon University
 
Beatrice Acha-Ngwodo
Summer Student, 2018
Undergraduate student, University of Maryland, College Park
 
Javdan Cameron
Summer Student, 2018
Undergraduate student, University of Maryland, College Park
 
Yang Li, MD
Special Volunteer, 2018
Ph.D. Student, Airforce Medical University 
 
Luana Martins de Carvalho, MS, PhD
Special Volunteer, 2018
Post-doctoral Fellow, University of Illinois, Chicago

Veronica Ramirez, BA
Post-Baccalaureate IRTA Fellow, 2016-2019
Graduate Student, UC Irvine Clinical Psychology PhD Program

Tyler Stodden, BS
Post-Baccalaureate IRTA Fellow, 2017-2019
Business Analyst, Flatiron Health

Jamie Burns, BS
Post-Baccalaureate IRTA Fellow, 2017-2019
Medical Student, University of Massachusetts School of Medicine

Christopher Kure Liu, BS
Post-Baccalaureate IRTA Fellow, 2017-2019
Medical Student, Touro University School of Medicine

Kai Yuan, PhD
Special Volunteer, 2018
Professor, School of Life Science and Technology, Xidian University, China

Minoo McFarland, CRNP
Nurse Practitioner, 2017-2019
Nurse Practitioner at Allergy clinic

Wenjing Zhao, PhD
Special Volunteer, 2017-2020
Taking Gap Year

Joseph Ramsey, BS
Post-Baccalaureate IRTA Fellow, 2018-2020
Medical/Doctoral Student, Vanderbilt University School of Medicine 

Danielle Kroll, BA
Post-Baccalaureate IRTA Fellow, 2018-2020
Medical Student, Columbia University Vagelos College of Physicians and Surgeons

Dana Feldman, BS
Post-Baccalaureate IRTA Fellow, 2018-2020
Medical Student, University of Michigan Medical School 

Katherine McPherson, BS
Post-Baccalaureate IRTA Fellow, 2019-2021
Medical Student, Albert Einstein College of Medicine 
 
Catherine Biesecker, BA
Post-Baccalaureate IRTA Fellow, 2019-2021
PhD Student, University of Louisville  
 

In Memory
Elena Shumay, MD, PhD

Elene Shumay

Elena was a staff geneticist at LNI. Her interests were in identifying genetic and epigenetic variations that could explain individual differences in brain imaging phenotype. Along with analysis of the accepted genetic markers, she is interested in discovering new polymorphisms in the known candidate genes, exploring previously unspecified genetic targets and assessing them as putative biomarkers.

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